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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 3
1993 1
1995 2
1996 3
1997 2
1998 4
1999 5
2000 6
2001 8
2002 13
2003 11
2004 22
2005 18
2006 20
2007 11
2008 15
2009 13
2010 23
2011 24
2012 24
2013 27
2014 26
2015 17
2016 14
2017 23
2018 21
2019 16
2020 14
2021 1
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349 results
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An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.
Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SEM, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pedersen A, Gravelle L, Tantawi S, Schambye H, Sethi T, MacKinnon AC. Vuong L, et al. Cancer Res. 2019 Apr 1;79(7):1480-1492. doi: 10.1158/0008-5472.CAN-18-2244. Epub 2019 Jan 23. Cancer Res. 2019. PMID: 30674531 Free article.
To examine the role of galectin-3 inhibition in NSCLC, we tested the effects of galectin-3 depletion using genetic and pharmacologic approaches on syngeneic mouse lung adenocarcinoma and human lung adenocarcinoma xenografts. …
To examine the role of galectin-3 inhibition in NSCLC, we tested the effects of galectin-3 depletion using genet …
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells.
Kouo T, Huang L, Pucsek AB, Cao M, Solt S, Armstrong T, Jaffee E. Kouo T, et al. Cancer Immunol Res. 2015 Apr;3(4):412-23. doi: 10.1158/2326-6066.CIR-14-0150. Epub 2015 Feb 17. Cancer Immunol Res. 2015. PMID: 25691328 Free PMC article.
We show that galectin-3 binds activated antigen-committed CD8(+) T cells only in the tumor microenvironment. ...Galectin-3 binds to LAG-3, and LAG-3 expression is necessary for galectin-3-mediated suppression of CD8(+) T cel …
We show that galectin-3 binds activated antigen-committed CD8(+) T cells only in the tumor microenvironment. ...Galectin
Galectin-3 activates TLR4/NF-kappaB signaling to promote lung adenocarcinoma cell proliferation through activating lncRNA-NEAT1 expression.
Zhou W, Chen X, Hu Q, Chen X, Chen Y, Huang L. Zhou W, et al. BMC Cancer. 2018 May 22;18(1):580. doi: 10.1186/s12885-018-4461-z. BMC Cancer. 2018. PMID: 29788922 Free PMC article.
Galectin-3 and TLR4 expression are abnormally up-regulated in lung adenocarcinoma tissues, and positively correlated with NEAT1 expression. CONCLUSION: We confirmed that Galectin-3 as a ligand of TLR4 induced TLR4 signaling activation in
Galectin-3 and TLR4 expression are abnormally up-regulated in lung adenocarcinoma tissues, and positively correl
Progress in molecular-based management of differentiated thyroid cancer.
Xing M, Haugen BR, Schlumberger M. Xing M, et al. Lancet. 2013 Mar 23;381(9871):1058-69. doi: 10.1016/S0140-6736(13)60109-9. Epub 2013 Mar 22. Lancet. 2013. PMID: 23668556 Free PMC article. Review.
Diagnostic molecular markers, such as RET-PTC, RAS, and BRAF(V600E) mutations; galectin 3; and a new gene expression classifier, are outstanding examples that have improved diagnosis of thyroid nodules. ...
Diagnostic molecular markers, such as RET-PTC, RAS, and BRAF(V600E) mutations; galectin 3; and a new gene expression classifie …
Galectin-3 and PTEN expression in pancreatic ductal adenocarcinoma, pancreatic neuroendocrine neoplasms and gastrointestinal tumors on fine-needle aspiration cytology.
Jiang K, Lawson D, Cohen C, Siddiqui MT. Jiang K, et al. Acta Cytol. 2014;58(3):281-7. doi: 10.1159/000362221. Epub 2014 May 13. Acta Cytol. 2014. PMID: 24854395 Free article.
OBJECTIVE: Galectin-3 has been implicated in the carcinogenesis of pancreatic ductal adenocarcinoma (PDAC). ...RESULTS: Forty-four of 46 PDAC FNA and 32 of 33 PDAC TMA demonstrated tumor-specific Galectin-3 positivity. In contrast, Galectin
OBJECTIVE: Galectin-3 has been implicated in the carcinogenesis of pancreatic ductal adenocarcinoma (PDAC). ...RESULTS: …
Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors.
Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S. Ajani JA, et al. Br J Cancer. 2018 Jan;118(1):52-61. doi: 10.1038/bjc.2017.388. Epub 2017 Nov 14. Br J Cancer. 2018. PMID: 29136404 Free PMC article.
BACKGROUND: Overexpression of Galectin-3 (Gal-3), a beta-galactoside binding protein, has been noted in many tumour types but its functional significance and clinical utility in gastric adenocarcinoma (GAC) are not well known. ...Gal-3 overexpre …
BACKGROUND: Overexpression of Galectin-3 (Gal-3), a beta-galactoside binding protein, has been noted in many tumour typ …
Galectin-3 is modulated in pancreatic cancer cells under hypoxia and nutrient deprivation.
da Silva Filho AF, Tavares LB, Pitta MGR, Beltrão EIC, Rêgo MJBM. da Silva Filho AF, et al. Biol Chem. 2020 Sep 25;401(10):1153-1165. doi: 10.1515/hsz-2019-0413. Biol Chem. 2020. PMID: 32755098
Galectin-3 has been evaluated in solid tumors and seems to present both pro/anti-tumor effects. ...PANC-1 showed increased Galectin-3 mRNA expression when cultivated in hypoxia for 24 and 48 h. ...
Galectin-3 has been evaluated in solid tumors and seems to present both pro/anti-tumor effects. ...PANC-1 showed increased
Expression and Distribution of Galectin-3 in Chromophobe and Papillary Carcinomas.
Cioca A, Muntean D, Bungardean C, Raica M, Cimpean AM. Cioca A, et al. Anticancer Res. 2018 Jan;38(1):259-263. doi: 10.21873/anticanres.12216. Anticancer Res. 2018. PMID: 29277781
Moreover, the optimal therapy for patients with non-clear renal cell carcinoma (RCC) is unknown yet. Although elevated levels of Galectin-3 (Gal-3) were associated with poor prognosis in conventional RCC, the impact of this protein on carcinogenesis of chromo …
Moreover, the optimal therapy for patients with non-clear renal cell carcinoma (RCC) is unknown yet. Although elevated levels of Galectin
Expression of galectin-1 and galectin-3 in renal cell carcinoma; immunohistochemical study.
Aboulhagag NA, El-Deek HEM, Sherif MF. Aboulhagag NA, et al. Ann Diagn Pathol. 2018 Oct;36:31-37. doi: 10.1016/j.anndiagpath.2018.06.005. Epub 2018 Jun 21. Ann Diagn Pathol. 2018. PMID: 30055522
Galectin-3 had high expression in 15 (22.4%) and low expression in 52 (77.6%) of specimens. ...CONCLUSION: Galectin-1 and galectin-3 are overexpressed in RCC with different percentage in different subtypes. ...
Galectin-3 had high expression in 15 (22.4%) and low expression in 52 (77.6%) of specimens. ...CONCLUSION: Galectin-1 a
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.
Wang L, Li YS, Yu LG, Zhang XK, Zhao L, Gong FL, Yang XX, Guo XL. Wang L, et al. Biochem Pharmacol. 2020 Aug;178:114113. doi: 10.1016/j.bcp.2020.114113. Epub 2020 Jun 21. Biochem Pharmacol. 2020. PMID: 32579956
It was found that the TAMs-mediated promotion of tumor growth and metastasis in hypoxia was inhibited by administration of macrophage-depletion agent clodronate liposomal (CL) or galectin-3 inhibitor modified citric pectin (MCP) in orthotopic syngeneic mammary ad
It was found that the TAMs-mediated promotion of tumor growth and metastasis in hypoxia was inhibited by administration of macrophage-deplet …
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