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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 3
1993 1
1995 2
1996 3
1997 2
1998 4
1999 5
2000 6
2001 8
2002 13
2003 11
2004 22
2005 18
2006 20
2007 11
2008 15
2009 13
2010 23
2011 24
2012 24
2013 27
2014 26
2015 17
2016 14
2017 23
2018 21
2019 16
2020 19
2021 10
2022 12
2023 17
2024 8

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395 results

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Page 1
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.
Chen X, Yu C, Liu X, Liu B, Wu X, Wu J, Yan D, Han L, Tang Z, Yuan X, Wang J, Wang Y, Liu S, Shan L, Shang Y. Chen X, et al. Nat Commun. 2022 Dec 8;13(1):7578. doi: 10.1038/s41467-022-35334-x. Nat Commun. 2022. PMID: 36481721 Free PMC article.
Here we report that intracellular galectin-3 interacts with Rag GTPases and Ragulator on lysosomes. We show that galectin-3 senses lipopolysaccharide (LPS) to facilitate the interaction of Rag GTPases and Ragulator, leading to the activation of mTORC1. …
Here we report that intracellular galectin-3 interacts with Rag GTPases and Ragulator on lysosomes. We show that galectin
Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases.
Fan Y, Song S, Li Y, Dhar SS, Jin J, Yoshimura K, Yao X, Wang R, Scott AW, Pizzi MP, Wu J, Ma L, Calin GA, Hanash S, Wang L, Curran M, Ajani JA. Fan Y, et al. Cancer Res. 2023 Nov 15;83(22):3726-3738. doi: 10.1158/0008-5472.CAN-23-0783. Cancer Res. 2023. PMID: 37738407 Free PMC article.
The peritoneal cavity is a common site of gastric adenocarcinoma (GAC) metastasis. Peritoneal carcinomatosis (PC) is resistant to current therapies and confers poor prognosis, highlighting the need to identify new therapeutic targets. ...Here, we found that CD47 was highly …
The peritoneal cavity is a common site of gastric adenocarcinoma (GAC) metastasis. Peritoneal carcinomatosis (PC) is resistant to cur …
Soluble galectin-3 as a microenvironment-relevant immunoregulator with prognostic and predictive value in lung adenocarcinoma.
Torres-Martínez S, Calabuig-Fariñas S, Moreno-Manuel A, Bertolini G, Herreros-Pomares A, Escorihuela E, Duréndez-Saéz E, Guijarro R, Blasco A, Roz L, Camps C, Jantus-Lewintre E. Torres-Martínez S, et al. Mol Oncol. 2024 Jan;18(1):190-215. doi: 10.1002/1878-0261.13505. Epub 2023 Nov 1. Mol Oncol. 2024. PMID: 37567864 Free PMC article.
The present study aims to analyze the role of galectin-3 (GAL-3) in the lung tumor microenvironment (TME) using tumorspheres as a model and explore its potential role as a predictive and prognostic biomarker in non-small cell lung cancer patients. For …
The present study aims to analyze the role of galectin-3 (GAL-3) in the lung tumor microenvironment (TME) using tumorsp …
Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis.
Choi YS, Kim MJ, Choi EA, Kim S, Lee EJ, Park MJ, Kim MJ, Kim YW, Ahn HS, Jung JY, Jang G, Kim Y, Kim H, Kim K, Kim JY, Hong SM, Kim SC, Chang S. Choi YS, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2119048119. doi: 10.1073/pnas.2119048119. Epub 2022 Jul 18. Proc Natl Acad Sci U S A. 2022. PMID: 35858411 Free PMC article.
The major challenges in pancreatic ductal adenocarcinoma (PDAC) management are local or distant metastasis and limited targeted therapeutics to prevent it. ...Knockdown and exogenous treatment of Gal-3BP showed that it is required for PDAC cell proliferation, migration, an …
The major challenges in pancreatic ductal adenocarcinoma (PDAC) management are local or distant metastasis and limited targeted thera …
Genetic Deletion of Galectin-3 Inhibits Pancreatic Cancer Progression and Enhances the Efficacy of Immunotherapy.
Yang D, Sun X, Moniruzzaman R, Wang H, Citu C, Zhao Z, Wistuba II, Wang H, Maitra A, Chen Y. Yang D, et al. Gastroenterology. 2024 Mar 11:S0016-5085(24)00288-9. doi: 10.1053/j.gastro.2024.03.007. Online ahead of print. Gastroenterology. 2024. PMID: 38467382
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) has a desmoplastic tumor stroma and immunosuppressive microenvironment. Galectin-3 (GAL3) is enriched in PDAC, highly expressed by cancer cells and myeloid cells. ...
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) has a desmoplastic tumor stroma and immunosuppressive microenvironment …
An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.
Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SEM, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pedersen A, Gravelle L, Tantawi S, Schambye H, Sethi T, MacKinnon AC. Vuong L, et al. Cancer Res. 2019 Apr 1;79(7):1480-1492. doi: 10.1158/0008-5472.CAN-18-2244. Epub 2019 Jan 23. Cancer Res. 2019. PMID: 30674531
To examine the role of galectin-3 inhibition in NSCLC, we tested the effects of galectin-3 depletion using genetic and pharmacologic approaches on syngeneic mouse lung adenocarcinoma and human lung adenocarcinoma xenografts. …
To examine the role of galectin-3 inhibition in NSCLC, we tested the effects of galectin-3 depletion using genet …
Galectin-3's Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential.
Dimitrijevic Stojanovic M, Stojanovic B, Radosavljevic I, Kovacevic V, Jovanovic I, Stojanovic BS, Prodanovic N, Stankovic V, Jocic M, Jovanovic M. Dimitrijevic Stojanovic M, et al. Biomolecules. 2023 Oct 10;13(10):1500. doi: 10.3390/biom13101500. Biomolecules. 2023. PMID: 37892182 Free PMC article. Review.
Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). ...
Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarci
Expression and Distribution of Galectin-3 in Chromophobe and Papillary Carcinomas.
Cioca A, Muntean D, Bungardean C, Raica M, Cimpean AM. Cioca A, et al. Anticancer Res. 2018 Jan;38(1):259-263. doi: 10.21873/anticanres.12216. Anticancer Res. 2018. PMID: 29277781
Moreover, the optimal therapy for patients with non-clear renal cell carcinoma (RCC) is unknown yet. Although elevated levels of Galectin-3 (Gal-3) were associated with poor prognosis in conventional RCC, the impact of this protein on carcinogenesis of chromophobe a …
Moreover, the optimal therapy for patients with non-clear renal cell carcinoma (RCC) is unknown yet. Although elevated levels of Galectin
Comparison between galectin-3 and YKL-40 levels for the assessment of liver fibrosis in cirrhotic patients.
Del Turco S, De Simone P, Ghinolfi D, Gaggini M, Basta G. Del Turco S, et al. Arab J Gastroenterol. 2021 Sep;22(3):187-192. doi: 10.1016/j.ajg.2021.03.002. Epub 2021 Jun 1. Arab J Gastroenterol. 2021. PMID: 34088622
BACKGROUND AND STUDY AIMS: The circulatory levels of Galectin-3 and YKL-40 are considered as candidate biomarkers for the noninvasive assessment of liver fibrosis. ...CONCLUSION: Circulating levels of Galectin-3 could be an indicator of liver damage an …
BACKGROUND AND STUDY AIMS: The circulatory levels of Galectin-3 and YKL-40 are considered as candidate biomarkers for the noni …
395 results