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520 results

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Page 1
Targeting galectin-3 in inflammatory and fibrotic diseases.
Bouffette S, Botez I, De Ceuninck F. Bouffette S, et al. Trends Pharmacol Sci. 2023 Aug;44(8):519-531. doi: 10.1016/j.tips.2023.06.001. Epub 2023 Jun 28. Trends Pharmacol Sci. 2023. PMID: 37391294 Free article. Review.
Galectin (Gal)-3 is a beta-galactoside-binding lectin emerging as a key player in cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections caused by COVID-19, and neuroinflammatory disorders. Here, we review recent information highlighting G …
Galectin (Gal)-3 is a beta-galactoside-binding lectin emerging as a key player in cardiac, hepatic, renal, and pulmonary fibrosis and inflam …
Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases.
Soares LC, Al-Dalahmah O, Hillis J, Young CC, Asbed I, Sakaguchi M, O'Neill E, Szele FG. Soares LC, et al. Cells. 2021 Nov 5;10(11):3047. doi: 10.3390/cells10113047. Cells. 2021. PMID: 34831271 Free PMC article. Review.
Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. ...
Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. ...
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Jia J, Claude-Taupin A, Gu Y, Choi SW, Peters R, Bissa B, Mudd MH, Allers L, Pallikkuth S, Lidke KA, Salemi M, Phinney B, Mari M, Reggiori F, Deretic V. Jia J, et al. Dev Cell. 2020 Jan 6;52(1):69-87.e8. doi: 10.1016/j.devcel.2019.10.025. Epub 2019 Dec 5. Dev Cell. 2020. PMID: 31813797 Free PMC article.
Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a beta-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage. ...
Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a beta-galactosid …
Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS. Morrison HM, et al. PLoS Pathog. 2023 Jun 23;19(6):e1011088. doi: 10.1371/journal.ppat.1011088. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37352334 Free PMC article.
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-containing phagosomes …
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cy …
Human galectin-1 and galectin-3 promote Tropheryma whipplei infection.
Ayona D, Zarza SM, Landemarre L, Roubinet B, Decloquement P, Raoult D, Fournier PE, Desnues B. Ayona D, et al. Gut Microbes. 2021 Jan-Dec;13(1):1-15. doi: 10.1080/19490976.2021.1884515. Gut Microbes. 2021. PMID: 33573443 Free PMC article.
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple's disease. The bacterium infects and replicates in macrophages, leading to a Th2-biased immune response. ...However, the exact contribution of these glycoprotein …
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple's disease. The bacterium …
Galectin-3 and Interleukin-17: A potential role in the pathogenesis of human papilloma virus infection.
Nw M, Ga A, Aa EF, Am H. Nw M, et al. J Cosmet Dermatol. 2022 Jun;21(6):2618-2622. doi: 10.1111/jocd.14430. Epub 2021 Oct 21. J Cosmet Dermatol. 2022. PMID: 34449950
BACKGROUND: In many cases, human papillomavirus (HPV) infection is self-limiting, as innate and adaptive cell-mediated immunity is needed for infection elimination; however, the inability of the immune system in some patients to clear the infection is a matte …
BACKGROUND: In many cases, human papillomavirus (HPV) infection is self-limiting, as innate and adaptive cell-mediated immunity is ne …
Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms.
Hatanaka O, Rezende CP, Moreno P, Freitas Fernandes F, Oliveira Brito PKM, Martinez R, Coelho C, Roque-Barreira MC, Casadevall A, Almeida F. Hatanaka O, et al. mSphere. 2019 Apr 24;4(2):e00209-19. doi: 10.1128/mSphere.00209-19. mSphere. 2019. PMID: 31019001 Free PMC article.
Galectin-3 (Gal-3), an animal beta-galactoside-binding protein, modulates important roles during microbial infections, such as triggering a Th2-polarized immune response in PCM. ...Although the immune mechanisms to control PCM are still not fully understood,
Galectin-3 (Gal-3), an animal beta-galactoside-binding protein, modulates important roles during microbial infections,
COVID-19 and Inflammatory Markers.
Balta S, Balta I. Balta S, et al. Curr Vasc Pharmacol. 2022;20(4):326-332. doi: 10.2174/1570161120666220404200205. Curr Vasc Pharmacol. 2022. PMID: 35379133 Review.
Asymmetric dimethylarginine, endocan, pentraxin 3, serum amyloid A, soluble urokinase plasminogen activator receptor, total oxidant status and total antioxidant status, and galectin-3 are considered among the emerging inflammatory markers. This brief narrative revie …
Asymmetric dimethylarginine, endocan, pentraxin 3, serum amyloid A, soluble urokinase plasminogen activator receptor, total oxidant status a …
Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection.
Snarr BD, St-Pierre G, Ralph B, Lehoux M, Sato Y, Rancourt A, Takazono T, Baistrocchi SR, Corsini R, Cheng MP, Sugrue M, Baden LR, Izumikawa K, Mukae H, Wingard JR, King IL, Divangahi M, Satoh MS, Yipp BG, Sato S, Sheppard DC. Snarr BD, et al. PLoS Pathog. 2020 Aug 4;16(8):e1008741. doi: 10.1371/journal.ppat.1008741. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32750085 Free PMC article.
Galectin-3 deficient mice displayed increased fungal burden and higher mortality during pulmonary infection. ...Live cell imaging studies revealed that extracellular galectin-3 directly increases neutrophil motility. Taken together, these data d
Galectin-3 deficient mice displayed increased fungal burden and higher mortality during pulmonary infection. ...Live ce
Galectin-3 Inhibition in COVID-19.
Reddy K, Nichol A, McAuley DF. Reddy K, et al. Am J Respir Crit Care Med. 2023 Jan 15;207(2):118-120. doi: 10.1164/rccm.202209-1758ED. Am J Respir Crit Care Med. 2023. PMID: 36154818 Free PMC article. No abstract available.
520 results