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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 3
1996 3
1997 2
1998 1
1999 3
2000 4
2001 5
2002 8
2003 3
2004 7
2005 6
2006 13
2007 11
2008 11
2009 20
2010 14
2011 14
2012 22
2013 30
2014 25
2015 30
2016 35
2017 35
2018 33
2019 35
2020 41
2021 64
2022 32
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447 results
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Page 1
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Yao RQ, Ren C, Xia ZF, Yao YM. Yao RQ, et al. Autophagy. 2021 Feb;17(2):385-401. doi: 10.1080/15548627.2020.1725377. Epub 2020 Feb 12. Autophagy. 2021. PMID: 32048886 Free PMC article. Review.
Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. In fact, those organelles synchronously pre …
Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructi …
Microglial phagocytosis of neurons in neurodegeneration, and its regulation.
Butler CA, Popescu AS, Kitchener EJA, Allendorf DH, Puigdellívol M, Brown GC. Butler CA, et al. J Neurochem. 2021 Aug;158(3):621-639. doi: 10.1111/jnc.15327. Epub 2021 Mar 17. J Neurochem. 2021. PMID: 33608912 Free article. Review.
Here, we review recent evidence that microglial phagocytosis of live neurons and synapses causes neurodegeneration in animal models of Alzheimer's disease and other tauopathies, Parkinson's disease, frontotemporal dementias, multiple sclerosis, retinal degeneration …
Here, we review recent evidence that microglial phagocytosis of live neurons and synapses causes neurodegeneration in animal models of Alzhe …
Human galectin-1 and galectin-3 promote Tropheryma whipplei infection.
Ayona D, Zarza SM, Landemarre L, Roubinet B, Decloquement P, Raoult D, Fournier PE, Desnues B. Ayona D, et al. Gut Microbes. 2021 Jan-Dec;13(1):1-15. doi: 10.1080/19490976.2021.1884515. Gut Microbes. 2021. PMID: 33573443 Free PMC article.
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple's disease. The bacterium infects and replicates in macrophages, leading to a Th2-biased immune response. ...However, the exact contribution of these glyco …
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple's disease. The bacter …
NETosis as a Pathogenic Factor for Heart Failure.
Ling S, Xu JW. Ling S, et al. Oxid Med Cell Longev. 2021 Feb 23;2021:6687096. doi: 10.1155/2021/6687096. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33680285 Free PMC article. Review.
Oxidative stress-mediated neutrophil extracellular traps (NETs) are the main immune defense mechanism against external bacterial infections. Furthermore, NETs play important roles in noninfectious diseases. ...In this review, we analyzed the markers of heart failure and he …
Oxidative stress-mediated neutrophil extracellular traps (NETs) are the main immune defense mechanism against external bacterial infectio
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Jia J, Claude-Taupin A, Gu Y, Choi SW, Peters R, Bissa B, Mudd MH, Allers L, Pallikkuth S, Lidke KA, Salemi M, Phinney B, Mari M, Reggiori F, Deretic V. Jia J, et al. Dev Cell. 2020 Jan 6;52(1):69-87.e8. doi: 10.1016/j.devcel.2019.10.025. Epub 2019 Dec 5. Dev Cell. 2020. PMID: 31813797 Free PMC article.
Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a beta-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage. ...
Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a beta-galactosid …
Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans.
Lo TH, Chen HL, Yao CI, Weng IC, Li CS, Huang CC, Chen NJ, Lin CH, Liu FT. Lo TH, et al. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2026246118. doi: 10.1073/pnas.2026246118. Proc Natl Acad Sci U S A. 2021. PMID: 34301890 Free PMC article.
Coimmunoprecipitation confirmed that galectin-3 associates with caspase-11 after intracellular delivery of LPSs. Immunofluorescence staining revealed colocalization of LPSs, galectin-3, and caspase-11 independent of host N-glycans. Thus, we conclude th …
Coimmunoprecipitation confirmed that galectin-3 associates with caspase-11 after intracellular delivery of LPSs. Immunofluores …
Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms.
Hatanaka O, Rezende CP, Moreno P, Freitas Fernandes F, Oliveira Brito PKM, Martinez R, Coelho C, Roque-Barreira MC, Casadevall A, Almeida F. Hatanaka O, et al. mSphere. 2019 Apr 24;4(2):e00209-19. doi: 10.1128/mSphere.00209-19. mSphere. 2019. PMID: 31019001 Free PMC article.
Galectin-3 (Gal-3), an animal beta-galactoside-binding protein, modulates important roles during microbial infections, such as triggering a Th2-polarized immune response in PCM. Herein, we demonstrate that Gal-3 also plays other important roles
Galectin-3 (Gal-3), an animal beta-galactoside-binding protein, modulates important roles during microbial infection
Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection.
Snarr BD, St-Pierre G, Ralph B, Lehoux M, Sato Y, Rancourt A, Takazono T, Baistrocchi SR, Corsini R, Cheng MP, Sugrue M, Baden LR, Izumikawa K, Mukae H, Wingard JR, King IL, Divangahi M, Satoh MS, Yipp BG, Sato S, Sheppard DC. Snarr BD, et al. PLoS Pathog. 2020 Aug 4;16(8):e1008741. doi: 10.1371/journal.ppat.1008741. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32750085 Free PMC article.
Galectin-3 deficient mice displayed increased fungal burden and higher mortality during pulmonary infection. ...Live cell imaging studies revealed that extracellular galectin-3 directly increases neutrophil motility. Taken together, these data d
Galectin-3 deficient mice displayed increased fungal burden and higher mortality during pulmonary infection. ...Live ce
Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis.
Rios FJ, Zou ZG, Harvey AP, Harvey KY, Nosalski R, Anyfanti P, Camargo LL, Lacchini S, Ryazanov AG, Ryazanova L, McGrath S, Guzik TJ, Goodyear CS, Montezano AC, Touyz RM. Rios FJ, et al. Cardiovasc Res. 2020 Mar 1;116(3):721-735. doi: 10.1093/cvr/cvz164. Cardiovasc Res. 2020. PMID: 31250885 Free PMC article.
These processes were associated with infiltration of inflammatory cells (F4/80+CD206+ cardiac macrophages) and increased galectin-3 expression. Cardiac [Mg2+]i, but not [Ca2+]i, was reduced in TRPM7+/deltakinase mice. ...Vascular functional and inflammatory response …
These processes were associated with infiltration of inflammatory cells (F4/80+CD206+ cardiac macrophages) and increased galectin- …
Galectin-3 and Its Genetic Variation rs4644 Modulate Enterovirus 71 Infection.
Huang WC, Chen HL, Chen HY, Peng KP, Lee Y, Huang LM, Chang LY, Liu FT. Huang WC, et al. PLoS One. 2016 Dec 21;11(12):e0168627. doi: 10.1371/journal.pone.0168627. eCollection 2016. PLoS One. 2016. PMID: 28002441 Free PMC article.
Galectin-3, a chimeric type beta-galactoside-binding protein, is known to modulate viral infection; however, its role in enterovirus 71 (EV71) infection has not been investigated. We generated galectin-3 null rhabdomyosarcoma (RD) cells a
Galectin-3, a chimeric type beta-galactoside-binding protein, is known to modulate viral infection; however, its role i
447 results