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Year Number of Results
1991 2
1992 1
1993 3
1994 3
1995 5
1996 8
1997 1
1998 9
1999 4
2000 6
2001 8
2002 9
2003 5
2004 11
2005 11
2006 22
2007 18
2008 18
2009 22
2010 18
2011 21
2012 28
2013 26
2014 15
2015 28
2016 24
2017 23
2018 21
2019 34
2020 11
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364 results
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Page 1
Galectin-3 modulation of T-cell activation: mechanisms of membrane remodelling.
Gilson RC, Gunasinghe SD, Johannes L, Gaus K. Gilson RC, et al. Prog Lipid Res. 2019 Oct;76:101010. doi: 10.1016/j.plipres.2019.101010. Epub 2019 Nov 1. Prog Lipid Res. 2019. PMID: 31682868 Review.
Galectin-3 (Gal3) is a multifaceted protein which belongs to a family of lectins and binds beta-galactosides. ...In this review, we seek to give an overview of the mechanisms by which Gal3 alters the spatial organization of cell membranes and how these proces
Galectin-3 (Gal3) is a multifaceted protein which belongs to a family of lectins and binds beta-galactosides. ...In this revie
Chlorin-Based Photoactivable Galectin-3-Inhibitor Nanoliposome for Enhanced Photodynamic Therapy and NK Cell-Related Immunity in Melanoma.
Wang S, Liu H, Xin J, Rahmanzadeh R, Wang J, Yao C, Zhang Z. Wang S, et al. ACS Appl Mater Interfaces. 2019 Nov 13;11(45):41829-41841. doi: 10.1021/acsami.9b09560. Epub 2019 Oct 29. ACS Appl Mater Interfaces. 2019. PMID: 31617343
Combined therapy and enhancing immune stimulation were proposed as effective strategies to overcome this resistance. In this paper, a Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome (PGIL) was designed for enhanced Melanoma PDT and immune activation o …
Combined therapy and enhancing immune stimulation were proposed as effective strategies to overcome this resistance. In this paper, a Chlori …
Galectin-3 regulates T-cell functions.
Hsu DK, Chen HY, Liu FT. Hsu DK, et al. Immunol Rev. 2009 Jul;230(1):114-27. doi: 10.1111/j.1600-065X.2009.00798.x. Immunol Rev. 2009. PMID: 19594632 Review.
These include viral transactivating factors, T-cell receptor (TCR) ligation, and calcium ionophores. In addition, galectin-3 is constitutively expressed in human regulatory T cells and CD4+ memory T cells. ...The rapid expansion of the fi …
These include viral transactivating factors, T-cell receptor (TCR) ligation, and calcium ionophores. In addition, galectin
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation.
Demetriou M, Granovsky M, Quaggin S, Dennis JW. Demetriou M, et al. Nature. 2001 Feb 8;409(6821):733-9. doi: 10.1038/35055582. Nature. 2001. PMID: 11217864
T-cell activation requires clustering of a threshold number of T-cell receptors (TCRs) at the site of antigen presentation, a number that is reduced by CD28 co-receptor recruitment of signalling proteins to TCRs. ...Indeed, galectin-3 was
T-cell activation requires clustering of a threshold number of T-cell receptors (TCRs) at the site of antigen pr
Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.
Lobry T, Miller R, Nevo N, Rocca CJ, Zhang J, Catz SD, Moore F, Thomas L, Pouly D, Bailleux A, Guerrera IC, Gubler MC, Cheung WW, Mak RH, Montier T, Antignac C, Cherqui S. Lobry T, et al. Kidney Int. 2019 Aug;96(2):350-362. doi: 10.1016/j.kint.2019.01.029. Epub 2019 Mar 6. Kidney Int. 2019. PMID: 30928021 Free PMC article.
Cystinosin was found to enhance lysosomal localization and degradation of galectin-3. In Ctns(-/-) mice, a mouse model of cystinosis, galectin-3 is overexpressed in the kidney. ...These data strongly suggest that galectin-3 mediates infla …
Cystinosin was found to enhance lysosomal localization and degradation of galectin-3. In Ctns(-/-) mice, a mouse model of cyst …
Selective effects of ginseng pectins on galectin-3-mediated T cell activation and apoptosis.
Xue H, Zhao Z, Lin Z, Geng J, Guan Y, Song C, Zhou Y, Tai G. Xue H, et al. Carbohydr Polym. 2019 Sep 1;219:121-129. doi: 10.1016/j.carbpol.2019.05.023. Epub 2019 May 8. Carbohydr Polym. 2019. PMID: 31151509
Galectin-3 (Gal-3) can induce T-cell activation and apoptosis and plays a role in tumor immune tolerance. Here, we demonstrate that ginseng pectins selectively inhibit Gal-3-induced T-cell apoptosis, while not affecting T
Galectin-3 (Gal-3) can induce T-cell activation and apoptosis and plays a role in tumor immune tolerance.
Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis.
Shi ZR, Tan GZ, Cao CX, Han YF, Meng Z, Man XY, Jiang ZX, Zhang YP, Dang NN, Wei KH, Bu DF, Liu FT, Wang L. Shi ZR, et al. J Autoimmun. 2018 May;89:30-40. doi: 10.1016/j.jaut.2017.11.002. Epub 2017 Nov 20. J Autoimmun. 2018. PMID: 29167025
The deficiency of epidermal galectin-3 is sufficient to promote development of psoriatic lesions, as evidenced by more severe skin inflammation in galectin-3 knockout (gal3(-/-)) mice, compared to wild-type mice, after imiquimod treatment, and in skin …
The deficiency of epidermal galectin-3 is sufficient to promote development of psoriatic lesions, as evidenced by more severe …
Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration.
Gordon-Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Gordon-Alonso M, et al. Nat Commun. 2017 Oct 6;8(1):793. doi: 10.1038/s41467-017-00925-6. Nat Commun. 2017. PMID: 28986561 Free PMC article.
Here, we describe how tumors can abolish IFNgamma-induced chemokines, thereby reducing T-cell attraction. This mechanism requires extracellular galectin-3, a lectin secreted by tumors. ...Here the authors show that galectin-3 secreted by …
Here, we describe how tumors can abolish IFNgamma-induced chemokines, thereby reducing T-cell attraction. This mechanism requi …
The immunological potential of galectin-1 and -3.
Dhirapong A, Lleo A, Leung P, Gershwin ME, Liu FT. Dhirapong A, et al. Autoimmun Rev. 2009 Mar;8(5):360-3. doi: 10.1016/j.autrev.2008.11.009. Epub 2008 Dec 6. Autoimmun Rev. 2009. PMID: 19064001 Review.
These proteins are expressed in both inflammatory and non-inflammatory cells including monocytes, macrophages, dendritic cells, mast cells, and B and T cells, giving a broad spectrum of involvement in the immune response. Galectins are uniquely capable of acting both intra …
These proteins are expressed in both inflammatory and non-inflammatory cells including monocytes, macrophages, dendritic cells, mast cells, …
Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8(+) T-cells and galectin-3 in the liver.
Rein-Fischboeck L, Haberl EM, Bajraktari G, Feder S, Pohl R, Eggenhofer E, Buechler C. Rein-Fischboeck L, et al. Exp Mol Pathol. 2020 Apr;113:104363. doi: 10.1016/j.yexmp.2019.104363. Epub 2019 Dec 24. Exp Mol Pathol. 2020. PMID: 31881201 Free article.
Further, there were more gammadelta T-cells in the NASH liver of the null mice. Galectin-3 protein in the hepatic non-parenchymal cell fraction was strongly induced in MCD diet fed wild type but not mutant mice. ...SNTA deficiency neither affected c
Further, there were more gammadelta T-cells in the NASH liver of the null mice. Galectin-3 protein in the hepatic non-p …
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