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Year Number of Results
1991 1
1993 1
1995 1
1997 2
1999 1
2000 2
2001 3
2002 5
2003 2
2004 1
2005 5
2006 9
2007 7
2008 11
2009 10
2010 7
2011 6
2012 6
2013 2
2014 5
2015 3
2016 11
2017 4
2018 7
2019 9
2020 8
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2022 7
2023 8
2024 1

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130 results

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Page 1
Current and future pharmacological therapies for NAFLD/NASH.
Sumida Y, Yoneda M. Sumida Y, et al. J Gastroenterol. 2018 Mar;53(3):362-376. doi: 10.1007/s00535-017-1415-1. Epub 2017 Dec 16. J Gastroenterol. 2018. PMID: 29247356 Free PMC article. Review.
This class of drug includes apoptosis signaling kinase 1 (ASK1) inhibitor and emricasan (an irreversible caspase inhibitor). A third target is intestinal microbiomes and metabolic endotoxemia. Several agents are in ongoing trials, including IMMe124, TLR4 antagonist, and so …
This class of drug includes apoptosis signaling kinase 1 (ASK1) inhibitor and emricasan (an irreversible caspase inhibitor). A third target …
Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins.
Leclaire C, Lecointe K, Gunning PA, Tribolo S, Kavanaugh DW, Wittmann A, Latousakis D, MacKenzie DA, Kawasaki N, Juge N. Leclaire C, et al. FASEB J. 2018 Jun;32(6):3301-3320. doi: 10.1096/fj.201700619R. Epub 2018 Jan 29. FASEB J. 2018. PMID: 29401627 Free PMC article.
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein-carbohydrate interactions. ...W., Wittmann, A., Latousakis, D., MacKenzie, D. A., Kawasaki, N., Juge, N. Molecular basis for intestinal mucin recognition by galectin-
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein-carbohydrate interactions. ...W., Wittmann
Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion.
Jiang K, Rankin CR, Nava P, Sumagin R, Kamekura R, Stowell SR, Feng M, Parkos CA, Nusrat A. Jiang K, et al. J Biol Chem. 2014 Apr 11;289(15):10510-10517. doi: 10.1074/jbc.M113.538538. Epub 2014 Feb 24. J Biol Chem. 2014. PMID: 24567334 Free PMC article.
The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellular adhesion. Human intestinal epithelial cells express the desmoglein-2 isoform. A proteomic screen for Dsg2-associated proteins in intestinal epithelial cells identified a lectin refe …
The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellular adhesion. Human intestinal epithelial cells expr …
Highlights on the Role of Galectin-3 in Colorectal Cancer and the Preventive/Therapeutic Potential of Food-Derived Inhibitors.
Aureli A, Del Cornò M, Marziani B, Gessani S, Conti L. Aureli A, et al. Cancers (Basel). 2022 Dec 22;15(1):52. doi: 10.3390/cancers15010052. Cancers (Basel). 2022. PMID: 36612048 Free PMC article. Review.
CRC risk is highly modifiable by lifestyle factors, including diet, which strongly influences both cancer incidence and related mortality. Galectin-3 (Gal-3) is a multifaceted protein involved in multiple pathophysiological pathways underlying chronic inflammation a …
CRC risk is highly modifiable by lifestyle factors, including diet, which strongly influences both cancer incidence and related mortality. …
Evaluation of galectin-3 and intestinal fatty acid binding protein as serum biomarkers in autosomal recessive polycystic kidney disease.
Fleischer LT, Ballester L, Dutt M, Howarth K, Poznick L, Darge K, Furth SL, Hartung EA. Fleischer LT, et al. J Nephrol. 2023 Jan;36(1):133-145. doi: 10.1007/s40620-022-01416-8. Epub 2022 Aug 18. J Nephrol. 2023. PMID: 35980535
BACKGROUND: Autosomal recessive polycystic kidney disease (ARPKD) causes fibrocystic kidney disease, congenital hepatic fibrosis, and portal hypertension. Serum galectin-3 (Gal-3) and intestinal fatty acid binding protein (I-FABP) are potential biomarkers of …
BACKGROUND: Autosomal recessive polycystic kidney disease (ARPKD) causes fibrocystic kidney disease, congenital hepatic fibrosis, and portal …
Galectin-3 as a Therapeutic Target for NSAID-Induced Intestinal Ulcers.
Park AM, Khadka S, Sato F, Omura S, Fujita M, Hsu DK, Liu FT, Tsunoda I. Park AM, et al. Front Immunol. 2020 Sep 23;11:550366. doi: 10.3389/fimmu.2020.550366. eCollection 2020. Front Immunol. 2020. PMID: 33072090 Free PMC article.
Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. ...Galectin-3 (Gal3), an endogenous lectin, has anti-microbial and pro-inflammatory functions. ...
Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small …
Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors.
Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S. Ajani JA, et al. Br J Cancer. 2018 Jan;118(1):52-61. doi: 10.1038/bjc.2017.388. Epub 2017 Nov 14. Br J Cancer. 2018. PMID: 29136404 Free PMC article.
BACKGROUND: Overexpression of Galectin-3 (Gal-3), a beta-galactoside binding protein, has been noted in many tumour types but its functional significance and clinical utility in gastric adenocarcinoma (GAC) are not well known. METHODS: We studied 184 GAC pati …
BACKGROUND: Overexpression of Galectin-3 (Gal-3), a beta-galactoside binding protein, has been noted in many tumour types but …
Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis.
Tsai HF, Wu CS, Chen YL, Liao HJ, Chyuan IT, Hsu PN. Tsai HF, et al. J Mol Med (Berl). 2016 May;94(5):545-56. doi: 10.1007/s00109-015-1368-x. Epub 2015 Dec 2. J Mol Med (Berl). 2016. PMID: 26631140
Adoptive transfer of galectin-3-treated T cells reduced bowel inflammation. Galectin-3 inhibited colonic mucosa inflammation by inducing regulatory T cells. Galectin-3 is a potential therapeutic approach in inflammatory bowel disease....
Adoptive transfer of galectin-3-treated T cells reduced bowel inflammation. Galectin-3 inhibited colonic mucosa …
Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells.
Puthenedam M, Wu F, Shetye A, Michaels A, Rhee KJ, Kwon JH. Puthenedam M, et al. Inflamm Bowel Dis. 2011 Jan;17(1):260-7. doi: 10.1002/ibd.21443. Epub 2010 Sep 1. Inflamm Bowel Dis. 2011. PMID: 20812334 Free PMC article.
The aim was to determine whether MMP7 cleaves galectin-3 and modulates wound healing in intestinal epithelial cells. ...This study has significance in understanding delayed wound healing in chronic intestinal diseases like intestinal ulcers
The aim was to determine whether MMP7 cleaves galectin-3 and modulates wound healing in intestinal epithelial cells. .. …
Serum galectin-3 level as a marker for diagnosis and prognosis of neonatal necrotising enterocolitis: a cohort study.
Zhou C, Li L, Feng X, Wang D, Liu Y, Li J, Song H, Feng B. Zhou C, et al. Am J Transl Res. 2021 May 15;13(5):5731-5737. eCollection 2021. Am J Transl Res. 2021. PMID: 34150182 Free PMC article.
Diagnosing NEC is difficult since it presents with various clinical appearances with divergent symptoms. This study determines the value of galectin-3 (GAL-3) for diagnosing NEC. METHODS: Seventy-two newborn patients with NEC and 64 preterm infants with jaundice (co …
Diagnosing NEC is difficult since it presents with various clinical appearances with divergent symptoms. This study determines the value of …
130 results