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42 results
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Chitinase-3 like-protein-1 function and its role in diseases.
Zhao T, Su Z, Li Y, Zhang X, You Q. Zhao T, et al. Signal Transduct Target Ther. 2020 Sep 14;5(1):201. doi: 10.1038/s41392-020-00303-7. Signal Transduct Target Ther. 2020. PMID: 32929074 Free PMC article. Review.
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. ...To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CH …
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. ...To date, interleukin-13 receptor subun …
Galectin-3: A key player in arthritis.
Hu Y, Yéléhé-Okouma M, Ea HK, Jouzeau JY, Reboul P. Hu Y, et al. Joint Bone Spine. 2017 Jan;84(1):15-20. doi: 10.1016/j.jbspin.2016.02.029. Epub 2016 May 26. Joint Bone Spine. 2017. PMID: 27238188 Free article. Review.
Amongst them, a beta-galactoside-binding lectin, galectin-3, has been reported to be highly expressed and secreted by inflamed synovium of rheumatoid arthritis and osteoarthritis patients. ...However, the mechanisms underlying its pathophysiological role in …
Amongst them, a beta-galactoside-binding lectin, galectin-3, has been reported to be highly expressed and secreted by inflamed …
Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis.
Forsman H, Islander U, Andréasson E, Andersson A, Onnheim K, Karlström A, Sävman K, Magnusson M, Brown KL, Karlsson A. Forsman H, et al. Arthritis Rheum. 2011 Feb;63(2):445-54. doi: 10.1002/art.30118. Arthritis Rheum. 2011. PMID: 21280000 Free article.
We undertook this study to investigate the influence of galectin 3 deficiency in a murine model of arthritis. METHODS: Wild-type (WT) and galectin 3-deficient (galectin 3(-/-) ) mice were subjected to antigen-induced arthritis …
We undertook this study to investigate the influence of galectin 3 deficiency in a murine model of arthritis. METHODS: …
Therapeutic Potential of Galectin-1 and Galectin-3 in Autoimmune Diseases.
He YS, Hu YQ, Xiang K, Chen Y, Feng YT, Yin KJ, Huang JX, Wang J, Wu ZD, Wang GH, Pan HF. He YS, et al. Curr Pharm Des. 2022;28(1):36-45. doi: 10.2174/1381612827666210927164935. Curr Pharm Des. 2022. PMID: 34579628 Review.
Recent studies have indicated that galectins exhibit pleiotropic roles in inflammation. Furthermore, emerging studies have found that galectins are involved in the occurrence and development of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid a …
Recent studies have indicated that galectins exhibit pleiotropic roles in inflammation. Furthermore, emerging studies have found that …
Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB.
Nielsen MA, Juul-Madsen K, Stegmayr J, Gao C, Mehta AY, Greisen SR, Kragstrup TW, Hvid M, Vorup-Jensen T, Cummings RD, Leffler H, Deleuran BW. Nielsen MA, et al. Front Immunol. 2022 Jun 24;13:915890. doi: 10.3389/fimmu.2022.915890. eCollection 2022. Front Immunol. 2022. PMID: 35812455 Free PMC article.
4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin-3 (Gal-3) decreases the cellular response to its ligand (4-1BBL). ...These results support that Gal-3 binds to 4-1BB wi …
4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin- …
Galectin-3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR-4-mediated oxidative stress pathway in TC28a2 human chondrocyte cells.
Chou WC, Tsai KL, Hsieh PL, Wu CH, Jou IM, Tu YK, Ma CH. Chou WC, et al. Environ Toxicol. 2022 Mar;37(3):478-488. doi: 10.1002/tox.23414. Epub 2021 Dec 11. Environ Toxicol. 2022. PMID: 34894372
The pathological changes of chondrocytes involve oxidative stress, the pro-inflammatory response, and pro-apoptotic events. Galectin-3 (Gal-3) is a 35 kDa protein with a special chimeric structure. ...Our study proves the pathogenic role of Gal-3 in Ga …
The pathological changes of chondrocytes involve oxidative stress, the pro-inflammatory response, and pro-apoptotic events. Galectin- …
Serum galectin-3 levels in patients with psoriasis.
Hayran Y, Allı N, Akpınar Ü, Öktem A, Yücel Ç, Fırat Oguz E, Turhan T. Hayran Y, et al. Int J Clin Pract. 2021 Oct;75(10):e14545. doi: 10.1111/ijcp.14545. Epub 2021 Jun 29. Int J Clin Pract. 2021. PMID: 34137138

A serum galectin-3 level >10 ng/mL increased the risk of psoriasis by 14.5 times (95% CI: 6.6-32.3, P < .001) and a serum galectin-3 level >10 ng/mL predicted psoriasis with 83.3% sensitivity and 74.3% specificity. ...CONC

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A serum galectin-3 level >10 ng/mL increased the risk of psoriasis by 14.5 times (95% CI: 6.6-32.3, P < .001) and

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Assessment of serum galectin-3 levels in acute rheumatic fever.
Epçaçan S, Ramoğlu MG, Epçaçan ZK, Baskın AK. Epçaçan S, et al. Turk J Pediatr. 2022;64(6):1050-1057. doi: 10.24953/turkjped.2022.79. Turk J Pediatr. 2022. PMID: 36583887 Free article.
BACKGROUND: Galectin-3 is a biomarker which takes a role in both acute and chronic inflammation as well as fibrosis and oxidative stress. ...Severity of carditis and galectin-3 levels were negatively correlated (r=-539, p=0.02). CONCLUSIONS: Chi …
BACKGROUND: Galectin-3 is a biomarker which takes a role in both acute and chronic inflammation as well as fibrosis and …
Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity.
Mendez-Huergo SP, Hockl PF, Stupirski JC, Maller SM, Morosi LG, Pinto NA, Berón AM, Musuruana JL, Nasswetter GG, Cavallasca JA, Rabinovich GA. Mendez-Huergo SP, et al. Front Immunol. 2019 Jan 9;9:3057. doi: 10.3389/fimmu.2018.03057. eCollection 2018. Front Immunol. 2019. PMID: 30687310 Free PMC article. Review.
In this perspective article we present new data highlighting the regulated expression of galectin-1 (Gal-1) and galectin-3 (Gal-3) in sera from RA patients under disease-modifying anti-rheumatic drugs (DMARDs) and/or corticoid treatment in the context …
In this perspective article we present new data highlighting the regulated expression of galectin-1 (Gal-1) and galectin-3 …
Galectin-3: its role in asthma and potential as an anti-inflammatory target.
Gao P, Simpson JL, Zhang J, Gibson PG. Gao P, et al. Respir Res. 2013 Dec 9;14(1):136. doi: 10.1186/1465-9921-14-136. Respir Res. 2013. PMID: 24313993 Free PMC article. Review.
Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammation, differentiation and apoptosis. Changes in galectin-3 (Gal-3) expression are commonly seen in cancer and pre-can …
Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammati …
42 results