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Galectin-3: A key player in arthritis.
Hu Y, Yéléhé-Okouma M, Ea HK, Jouzeau JY, Reboul P. Hu Y, et al. Joint Bone Spine. 2017 Jan;84(1):15-20. doi: 10.1016/j.jbspin.2016.02.029. Epub 2016 May 26. Joint Bone Spine. 2017. PMID: 27238188 Review.
Amongst them, a beta-galactoside-binding lectin, galectin-3, has been reported to be highly expressed and secreted by inflamed synovium of rheumatoid arthritis and osteoarthritis patients. ...However, the mechanisms underlying its pathophysiological role in …
Amongst them, a beta-galactoside-binding lectin, galectin-3, has been reported to be highly expressed and secreted by inflamed …
Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis.
Forsman H, Islander U, Andréasson E, Andersson A, Onnheim K, Karlström A, Sävman K, Magnusson M, Brown KL, Karlsson A. Forsman H, et al. Arthritis Rheum. 2011 Feb;63(2):445-54. doi: 10.1002/art.30118. Arthritis Rheum. 2011. PMID: 21280000 Free article.
We undertook this study to investigate the influence of galectin 3 deficiency in a murine model of arthritis. METHODS: Wild-type (WT) and galectin 3-deficient (galectin 3(-/-) ) mice were subjected to antigen-induced arthritis …
We undertook this study to investigate the influence of galectin 3 deficiency in a murine model of arthritis. METHODS: …
Galectin-3-null mice display defective neutrophil clearance during acute inflammation.
Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV, Cooper D. Wright RD, et al. J Leukoc Biol. 2017 Mar;101(3):717-726. doi: 10.1189/jlb.3A0116-026RR. Epub 2016 Oct 12. J Leukoc Biol. 2017. PMID: 27733579 Free PMC article.
Galectin-3 has been associated with a plethora of proinflammatory functions because of its ability, among others, to promote neutrophil activation and because of the reduction in neutrophil recruitment in models of infection in Gal-3-null mice. ...These data …
Galectin-3 has been associated with a plethora of proinflammatory functions because of its ability, among others, to promote n …
Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity.
Mendez-Huergo SP, Hockl PF, Stupirski JC, Maller SM, Morosi LG, Pinto NA, Berón AM, Musuruana JL, Nasswetter GG, Cavallasca JA, Rabinovich GA. Mendez-Huergo SP, et al. Front Immunol. 2019 Jan 9;9:3057. doi: 10.3389/fimmu.2018.03057. eCollection 2018. Front Immunol. 2019. PMID: 30687310 Free PMC article. Review.
In this perspective article we present new data highlighting the regulated expression of galectin-1 (Gal-1) and galectin-3 (Gal-3) in sera from RA patients under disease-modifying anti-rheumatic drugs (DMARDs) and/or corticoid treatment in the context …
In this perspective article we present new data highlighting the regulated expression of galectin-1 (Gal-1) and galectin-3 …
Chitinase-3 like-protein-1 function and its role in diseases.
Zhao T, Su Z, Li Y, Zhang X, You Q. Zhao T, et al. Signal Transduct Target Ther. 2020 Sep 14;5(1):201. doi: 10.1038/s41392-020-00303-7. Signal Transduct Target Ther. 2020. PMID: 32929074 Free PMC article. Review.
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. ...To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CH …
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. ...To date, interleukin-13 receptor subun …
Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts.
Arad U, Madar-Balakirski N, Angel-Korman A, Amir S, Tzadok S, Segal O, Menachem A, Gold A, Elkayam O, Caspi D. Arad U, et al. Cytokine. 2015 May;73(1):30-5. doi: 10.1016/j.cyto.2015.01.016. Epub 2015 Feb 14. Cytokine. 2015. PMID: 25689620
It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order to better understand the mechanism(s) …
It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of ga …
Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity.
Issa SF, Christensen AF, Lindegaard HM, Hetland ML, Hørslev-Petersen K, Stengaard-Pedersen K, Ejbjerg BJ, Lottenburger T, Ellingsen T, Pedersen JK, Junker K, Svendsen A, Tarp U, Østergaard M, Junker P. Issa SF, et al. Scand J Immunol. 2017 Dec;86(6):471-478. doi: 10.1111/sji.12619. Epub 2017 Nov 1. Scand J Immunol. 2017. PMID: 28990250 Free article.
Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). ...One hundred and nineteen, 87 and 60 blood donors served as controls for galectin-3, HYA and PIIINP, respectively. Baseline …
Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). …
Association of galectin-3 with markers of myocardial function, atherosclerosis, and vascular fibrosis in patients with rheumatoid arthritis.
Anyfanti P, Gkaliagkousi E, Gavriilaki E, Triantafyllou A, Dolgyras P, Galanopoulou V, Aslanidis S, Douma S. Anyfanti P, et al. Clin Cardiol. 2019 Jan;42(1):62-68. doi: 10.1002/clc.23105. Epub 2018 Nov 27. Clin Cardiol. 2019. PMID: 30353563 Free PMC article.
HYPOTHESIS: We investigated whether galectin-3 correlates with markers of vascular fibrosis, subclinical atherosclerosis, and cardiac function in patients with rheumatoid arthritis (RA), a disease accompanied by high cardiovascular risk. ...CONCLUSIONS: In a …
HYPOTHESIS: We investigated whether galectin-3 correlates with markers of vascular fibrosis, subclinical atherosclerosis, and …
Galectin-3: its role in asthma and potential as an anti-inflammatory target.
Gao P, Simpson JL, Zhang J, Gibson PG. Gao P, et al. Respir Res. 2013 Dec 9;14(1):136. doi: 10.1186/1465-9921-14-136. Respir Res. 2013. PMID: 24313993 Free PMC article. Review.
Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammation, differentiation and apoptosis. Changes in galectin-3 (Gal-3) expression are commonly seen in cancer and pre-can …
Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammati …
Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility.
Reesink HL, Sutton RM, Shurer CR, Peterson RP, Tan JS, Su J, Paszek MJ, Nixon AJ. Reesink HL, et al. Stem Cell Res Ther. 2017 Nov 2;8(1):243. doi: 10.1186/s13287-017-0691-2. Stem Cell Res Ther. 2017. PMID: 29096716 Free PMC article.
Galectins, a family of beta-galactoside binding proteins, regulate inflammation, adhesion and cell migration in diverse cell types. Galectin-1 and galectin-3 are proposed to be important intra-articular modulators of inflammation in both osteoar …
Galectins, a family of beta-galactoside binding proteins, regulate inflammation, adhesion and cell migration in diverse cell types. …
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