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1995 2
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Page 1
Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target.
Capone E, Iacobelli S, Sala G. Capone E, et al. J Transl Med. 2021 Sep 26;19(1):405. doi: 10.1186/s12967-021-03085-w. J Transl Med. 2021. PMID: 34565385 Free PMC article. Review.
The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associated protein, while its role in innate immune respons …
The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the …
Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
Keinänen O, Sarrett SM, Delaney S, Rodriguez C, Dayts EJ, Capone E, Sauniere F, Ippoliti R, Sala G, Iacobelli S, Zeglis BM. Keinänen O, et al. Mol Pharm. 2023 Jun 5;20(6):3241-3248. doi: 10.1021/acs.molpharmaceut.3c00241. Epub 2023 May 16. Mol Pharm. 2023. PMID: 37191353 Free PMC article.
Galectin-3 binding protein (Gal-3BP) is a glycoprotein that is overexpressed and secreted by several cancers and has been implicated as a marker of both tumor progression and poor prognosis in melanoma, non-small cell lung cancer, head and neck squamou
Galectin-3 binding protein (Gal-3BP) is a glycoprotein that is overexpressed and secreted by several cancers and
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2.
Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. Panigrahi A, et al. bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572603. doi: 10.1101/2023.12.20.572603. bioRxiv. 2023. PMID: 38187586 Free PMC article. Preprint.
In spite of its importance, limited information is available on direct protein-protein interactions of the Sulf-2 protein in the tumor microenvironment. In this study, we used monoclonal antibody (mAb) affinity purification and mass spectrometry to identify …
In spite of its importance, limited information is available on direct protein-protein interactions of the Sulf-2 protein
Galectin-3-binding protein and future venous thromboembolism.
Hansen ES, Edvardsen MS, Aukrust P, Ueland T, Hansen JB, Brækkan SK, Morelli VM. Hansen ES, et al. Res Pract Thromb Haemost. 2024 Jan 3;8(1):102311. doi: 10.1016/j.rpth.2023.102311. eCollection 2024 Jan. Res Pract Thromb Haemost. 2024. PMID: 38327613 Free PMC article. No abstract available.
Galectin-3 Binding Protein, Depression, and Younger Age Were Independently Associated With Alexithymia in Adult Patients With Type 1 Diabetes.
Melin EO, Svensson R, Dereke J, Hillman M. Melin EO, et al. Front Psychiatry. 2021 May 11;12:672931. doi: 10.3389/fpsyt.2021.672931. eCollection 2021. Front Psychiatry. 2021. PMID: 34045984 Free PMC article.
The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s)CD163 and galectin-3 were independently associated with alexithymia, while controlling for known risk factors for cardiovascular disease, s …
The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s …
Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis.
Choi YS, Kim MJ, Choi EA, Kim S, Lee EJ, Park MJ, Kim MJ, Kim YW, Ahn HS, Jung JY, Jang G, Kim Y, Kim H, Kim K, Kim JY, Hong SM, Kim SC, Chang S. Choi YS, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2119048119. doi: 10.1073/pnas.2119048119. Epub 2022 Jul 18. Proc Natl Acad Sci U S A. 2022. PMID: 35858411 Free PMC article.
To identify a druggable target in tumor secretome and to explore its therapeutic intervention, we performed a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic analysis of tumors obtained from a patient-derived xenograft model of PDAC. Galectin-3
To identify a druggable target in tumor secretome and to explore its therapeutic intervention, we performed a liquid chromatography-tandem m …
Urine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus.
Faustini F, Idborg H, Fuzzi E, Larsson A, Lie WR, Pötzsch S, Okitsu SL, Svenungsson E, Gunnarsson I. Faustini F, et al. Lupus. 2023 Feb;32(2):252-262. doi: 10.1177/09612033221145534. Epub 2022 Dec 12. Lupus. 2023. PMID: 36508734 Free PMC article.
Non-invasive urine biomarkers are an active area of investigation to support LN diagnosis and management. OBJECTIVE: To investigate the role of urinary galectin-3 binding protein (u-Gal-3BP) as a candidate biomarker of renal disease in biopsy proven LN …
Non-invasive urine biomarkers are an active area of investigation to support LN diagnosis and management. OBJECTIVE: To investigate the role …
Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure.
Sindrewicz P, Yates EA, Turnbull JE, Lian LY, Yu LG. Sindrewicz P, et al. Biochem Biophys Res Commun. 2020 Mar 5;523(2):336-341. doi: 10.1016/j.bbrc.2019.12.054. Epub 2019 Dec 19. Biochem Biophys Res Commun. 2020. PMID: 31866013
Inhibition of the galectin-3-mediated actions is increasingly considered as a promising therapeutic approach for cancer treatment. Our early studies have identified several novel galectin-3 binding inhibitors from chemical modification of the anticoagulant dr …
Inhibition of the galectin-3-mediated actions is increasingly considered as a promising therapeutic approach for cancer treatment. Our early …
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines.
Mendes-Frias A, Gallo V, Iacobelli V, Gentile R, Antonini G, Silvestre R, Iacobelli S. Mendes-Frias A, et al. Sci Rep. 2022 Oct 11;12(1):17047. doi: 10.1038/s41598-022-20852-x. Sci Rep. 2022. PMID: 36220879 Free PMC article.
Galectin-3 (Gal-3) is a receptor present at the surface of different cell types, namely epithelial and inflammatory cells, which has been described as a severity marker in COVID-19. The activation of Gal-3 through its binding protein (Gal-3BP) is directly linked to the pro …
Galectin-3 (Gal-3) is a receptor present at the surface of different cell types, namely epithelial and inflammatory cells, which has been de …
Serum galectin-3 and galectin-3 binding protein levels in systemic lupus erythematosus and cutaneous lupus erythematosus.
Kalinska-Bienias A, Kowalczyk E, Bienias P, Gala K, Jagielski P, Kowalewski C. Kalinska-Bienias A, et al. Postepy Dermatol Alergol. 2021 Apr;38(2):274-280. doi: 10.5114/ada.2020.92320. Epub 2020 Jan 17. Postepy Dermatol Alergol. 2021. PMID: 34408596 Free PMC article.
INTRODUCTION: The roles of galectin-3 (Gal-3) and galectin-3 binding protein (G3BP) in systemic lupus erythematosus (SLE) are of ongoing interest, but the data are insufficient due to highly limited available studies. ...AIM: To assess serum Gal-3 and …
INTRODUCTION: The roles of galectin-3 (Gal-3) and galectin-3 binding protein (G3BP) in systemic lupus erythemato …
272 results