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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data.
WWARN Gametocyte Study Group. WWARN Gametocyte Study Group. BMC Med. 2016 May 24;14:79. doi: 10.1186/s12916-016-0621-7. BMC Med. 2016. PMID: 27221542 Free PMC article. Review.
Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. ...CONCLUSIONS: AS-MQ and AL are more effective than DP and AS-AQ FDC in preventing gametocytaemia short
Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, pa
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Saito M, Mansoor R, Kennon K, Anvikar AR, Ashley EA, Chandramohan D, Cohee LM, D'Alessandro U, Genton B, Gilder ME, Juma E, Kalilani-Phiri L, Kuepfer I, Laufer MK, Lwin KM, Meshnick SR, Mosha D, Mwapasa V, Mwebaza N, Nambozi M, Ndiaye JA, Nosten F, Nyunt M, Ogutu B, Parikh S, Paw MK, Phyo AP, Pimanpanarak M, Piola P, Rijken MJ, Sriprawat K, Tagbor HK, Tarning J, Tinto H, Valéa I, Valecha N, White NJ, Wiladphaingern J, Stepniewska K, McGready R, Guérin PJ. Saito M, et al. Lancet Infect Dis. 2020 Aug;20(8):943-952. doi: 10.1016/S1473-3099(20)30064-5. Epub 2020 Apr 29. Lancet Infect Dis. 2020. PMID: 32530424 Free PMC article.
BACKGROUND: Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for uncomplicated (including asymptomatic) falciparum malaria in pregnant women is scarce and assessed in varied ways. ...T …
BACKGROUND: Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for …
Gametocyte clearance in children, from western Kenya, with uncomplicated Plasmodium falciparum malaria after artemether-lumefantrine or dihydroartemisinin-piperaquine treatment.
Omondi P, Burugu M, Matoke-Muhia D, Too E, Nambati EA, Chege W, Musyoka KB, Thiongo K, Otinga M, Muregi F, Kimani F. Omondi P, et al. Malar J. 2019 Dec 4;18(1):398. doi: 10.1186/s12936-019-3032-3. Malar J. 2019. PMID: 31801562 Free PMC article.
METHODS: Children aged between 0.5 and 12 years from Busia, western Kenya with uncomplicated Plasmodium falciparum malaria were assigned randomly to AL or DP treatment. ...Plasmodium falciparum gametocytes were detected by q …
METHODS: Children aged between 0.5 and 12 years from Busia, western Kenya with uncomplicated Plasmodium falciparum m
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia.
Abamecha A, Yilma D, Addisu W, El-Abid H, Ibenthal A, Noedl H, Yewhalaw D, Moumni M, Abdissa A. Abamecha A, et al. Malar J. 2020 Jul 10;19(1):240. doi: 10.1186/s12936-020-03307-4. Malar J. 2020. PMID: 32650784 Free PMC article.
BACKGROUND: The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. ...METHODS: The study was a one-arm, prospective, evaluation of the clinical an …
BACKGROUND: The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum
Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children.
Djimde AA, Maiga AW, Ouologuem D, Fofana B, Sagara I, Dembele D, Toure S, Sanogo K, Dama S, Sidibe B, Doumbo OK. Djimde AA, et al. Parasite. 2016;23:3. doi: 10.1051/parasite/2016003. Epub 2016 Feb 2. Parasite. 2016. PMID: 26839003 Free PMC article. Clinical Trial.
Artemisinin-based combination therapies decrease Plasmodium gametocyte carriage. ...In both studies, although gametocyte carriage significantly decreased by the end of the 28-day follow-up, artesunate did not clear mature gameto
Artemisinin-based combination therapies decrease Plasmodium gametocyte carriage. ...In both studies, although
Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance.
Okafor HU, Shu EN, Oguonu T. Okafor HU, et al. J Trop Pediatr. 2010 Dec;56(6):398-406. doi: 10.1093/tropej/fmq004. Epub 2010 Feb 8. J Trop Pediatr. 2010. PMID: 20144932 Clinical Trial.
Combination therapy with artemesinin or non-artemesinin-based antimalarials (ACTs or NACTs) are known to retard the development and progression of drug resistance in Plasmodium falciparum (P. falciparum). ...Day 28 cure rates were 91.4 and 89.9% (PCR-c …
Combination therapy with artemesinin or non-artemesinin-based antimalarials (ACTs or NACTs) are known to retard the development and p …
Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether-lumefantrine.
Shekalaghe S, Mosha D, Hamad A, Mbaga TA, Mihayo M, Bousema T, Drakeley C, Abdulla S. Shekalaghe S, et al. Malar J. 2020 Jan 21;19(1):34. doi: 10.1186/s12936-020-3121-3. Malar J. 2020. PMID: 31964380 Free PMC article. Clinical Trial.
BACKGROUND: Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission. ...METHODS: In an individual-level randomized controlled trial, enroll …
BACKGROUND: Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for preventio …
Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.
Osorio L, Gonzalez I, Olliaro P, Taylor WR. Osorio L, et al. Malar J. 2007 Feb 28;6:25. doi: 10.1186/1475-2875-6-25. Malar J. 2007. PMID: 17328806 Free PMC article. Clinical Trial.
BACKGROUND: Artemisinin-based combination therapy (ACT) is being widely promoted as a strategy to counteract the increase in Plasmodium falciparum antimalarial drug resistance. ...Patients' follow-up is problematic in areas with dispersed popula …
BACKGROUND: Artemisinin-based combination therapy (ACT) is being widely promoted as a strategy to counteract the increase in …
Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria.
Karl S, Laman M, Moore BR, Benjamin JM, Salib M, Lorry L, Maripal S, Siba P, Robinson LJ, Mueller I, Davis TM. Karl S, et al. Acta Trop. 2016 Aug;160:1-8. doi: 10.1016/j.actatropica.2016.04.002. Epub 2016 Apr 4. Acta Trop. 2016. PMID: 27056132 Clinical Trial.
There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in children from areas with transmission of multiple Plasmodium species. ...Consistent with slow P. falciparum gametocyte ma …
There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in ch …
Efficacy of artemether-lumefantrine therapy for the treatment of uncomplicated Plasmodium falciparum malaria in Southwestern Ethiopia.
Mekonnen SK, Medhin G, Berhe N, Clouse RM, Aseffa A. Mekonnen SK, et al. Malar J. 2015 Aug 15;14:317. doi: 10.1186/s12936-015-0826-9. Malar J. 2015. PMID: 26271736 Free PMC article. Clinical Trial.
BACKGROUND: The development and spread of chloroquine-resistant Plasmodium falciparum threatens the health of millions of people and poses a major challenge to the control of malaria. ...CONCLUSIONS: Years after the introduction of AL in Ethiopia, the finding …
BACKGROUND: The development and spread of chloroquine-resistant Plasmodium falciparum threatens the health of millions of peop …
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