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The following term was not found in PubMed: gamma-campholenic
Page 1
Aldehyde-Associated MutagenesisCurrent State of Knowledge.
Vijayraghavan S, Saini N. Vijayraghavan S, et al. Chem Res Toxicol. 2023 Jul 17;36(7):983-1001. doi: 10.1021/acs.chemrestox.3c00045. Epub 2023 Jun 26. Chem Res Toxicol. 2023. PMID: 37363863 Free PMC article. Review.
Here, we review the genotoxic effects of various aldehydes, focusing particularly on the DNA adducts underlying the mutagenicity of environmentally derived aldehydes. We summarize the chemical structures of the aldehydes and their predominant DNA adducts, dis …
Here, we review the genotoxic effects of various aldehydes, focusing particularly on the DNA adducts underlying the mutagenicity of e …
Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium.
Rwere F, Yu X, Chen CH, Gross ER. Rwere F, et al. Biomolecules. 2022 May 30;12(6):763. doi: 10.3390/biom12060763. Biomolecules. 2022. PMID: 35740888 Free PMC article.
The discovery of aldehydes dates back to 1774 when Carl Wilhelm Scheele synthesized acetaldehyde [...]....
The discovery of aldehydes dates back to 1774 when Carl Wilhelm Scheele synthesized acetaldehyde [...]....
Microbial engineering for aldehyde synthesis.
Kunjapur AM, Prather KL. Kunjapur AM, et al. Appl Environ Microbiol. 2015 Mar;81(6):1892-901. doi: 10.1128/AEM.03319-14. Epub 2015 Jan 9. Appl Environ Microbiol. 2015. PMID: 25576610 Free PMC article. Review.
Aldehydes are a class of chemicals with many industrial uses. Several aldehydes are responsible for flavors and fragrances present in plants, but aldehydes are not known to accumulate in most natural microorganisms. ...Such efforts have provided a foundation …
Aldehydes are a class of chemicals with many industrial uses. Several aldehydes are responsible for flavors and fragrances pre …
Genotoxicity of lipid oxidation compounds.
Eckl PM, Bresgen N. Eckl PM, et al. Free Radic Biol Med. 2017 Oct;111:244-252. doi: 10.1016/j.freeradbiomed.2017.02.002. Epub 2017 Feb 5. Free Radic Biol Med. 2017. PMID: 28167130 Review.
Lipid peroxidation, the oxidative degradation of membrane lipids by reactive oxygen species generates a large variety of breakdown products such as alkanes, aldehydes, ketones, alcohols, furans and others. Due to their reactivity aldehydes (alkanals, 2-alkenals, 2,4 …
Lipid peroxidation, the oxidative degradation of membrane lipids by reactive oxygen species generates a large variety of breakdown products …
From aldehyde metabolism to delay aging: targeting ALDH2 as a novel strategy.
Yang P, Su W, Wang L, Xu F, Kong Y, Long J. Yang P, et al. Free Radic Biol Med. 2025 Aug 16;236:70-86. doi: 10.1016/j.freeradbiomed.2025.05.389. Epub 2025 May 9. Free Radic Biol Med. 2025. PMID: 40349798 Review.
Its primary role is to catalyze the oxidation of aldehydes, resulting in the formation of their corresponding acid metabolites. This paper presents a succinct overview of the sources and metabolic pathways of key aldehydes within the human body, compares the various …
Its primary role is to catalyze the oxidation of aldehydes, resulting in the formation of their corresponding acid metabolites. This …
Intracellular metabolism of 4-hydroxynonenal.
Siems W, Grune T. Siems W, et al. Mol Aspects Med. 2003 Aug-Oct;24(4-5):167-75. doi: 10.1016/s0098-2997(03)00011-6. Mol Aspects Med. 2003. PMID: 12892994 Review.
4-hydroxynonenal (HNE) is a major aldehydic product of lipid peroxidation known to exert a multitude of biological, cytotoxic, and signal effects. ...The rapid metabolism underlines the role of HNE degrading pathways in mammalian cells as important part of the secondary an …
4-hydroxynonenal (HNE) is a major aldehydic product of lipid peroxidation known to exert a multitude of biological, cytotoxic, and si …
Mitochondrial aldehyde dehydrogenase 2 activation and cardioprotection.
Gong D, Zhang H, Hu S. Gong D, et al. J Mol Cell Cardiol. 2013 Feb;55:58-63. doi: 10.1016/j.yjmcc.2012.03.017. Epub 2012 Apr 6. J Mol Cell Cardiol. 2013. PMID: 22507541 Review.
Cardiac ischemia and reperfusion promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. Mitochondrial aldehyde dehydrogenase 2 is emerging as a key cardioprotective enzyme for its central role in the detoxification of …
Cardiac ischemia and reperfusion promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damag …
Mitochondrial aldehyde dehydrogenase and cardiac diseases.
Chen CH, Sun L, Mochly-Rosen D. Chen CH, et al. Cardiovasc Res. 2010 Oct 1;88(1):51-7. doi: 10.1093/cvr/cvq192. Epub 2010 Jun 16. Cardiovasc Res. 2010. PMID: 20558439 Free PMC article. Review.
Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxi …
Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes that cause cell damage and contribute to …
Environmental Aldehyde Sources and the Health Implications of Exposure.
Sinharoy P, McAllister SL, Vasu M, Gross ER. Sinharoy P, et al. Adv Exp Med Biol. 2019;1193:35-52. doi: 10.1007/978-981-13-6260-6_2. Adv Exp Med Biol. 2019. PMID: 31368096 Free PMC article. Review.
To prevent harm from reactive aldehyde exposure, the enzyme aldehyde dehydrogenase 2 (ALDH2) metabolizes reactive aldehydes to a less toxic form. However, the genetic variant of ALDH2, ALDH2*2, significantly reduces the ability to metabolize reactive aldeh …
To prevent harm from reactive aldehyde exposure, the enzyme aldehyde dehydrogenase 2 (ALDH2) metabolizes reactive aldehydes …
Pathophysiological relevance of aldehydic protein modifications.
Zarkovic N, Cipak A, Jaganjac M, Borovic S, Zarkovic K. Zarkovic N, et al. J Proteomics. 2013 Oct 30;92:239-47. doi: 10.1016/j.jprot.2013.02.004. Epub 2013 Feb 22. J Proteomics. 2013. PMID: 23438936 Review.
Thus generated reactive aldehydes are considered as second messengers of free radicals because they react with major bioactive macromolecules, in particular with various humoral and cellular proteins changing their structure and functions. Therefore, the aldehydic-p …
Thus generated reactive aldehydes are considered as second messengers of free radicals because they react with major bioactive macrom …
176,420 results
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