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Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats.
Khursheed R, Singh SK, Kumar B, Wadhwa S, Gulati M, A A, Awasthi A, Vishwas S, Kaur J, Corrie L, K R A, Kumar R, Jha NK, Gupta PK, Zacconi F, Dua K, Chitranshi N, Mustafa G, Kumar A. Khursheed R, et al. Int J Pharm. 2022 Jan 25;612:121306. doi: 10.1016/j.ijpharm.2021.121306. Epub 2021 Nov 20. Int J Pharm. 2022. PMID: 34813906
The prepared L-SNEDDS were solidified using Ganoderma lucidum extract, probiotics and Aerosil-200 using spray drying. These were further converted into pellets using extrusion-spheronization. ...
The prepared L-SNEDDS were solidified using Ganoderma lucidum extract, probiotics and Aerosil-200 using spray drying. These were furt …
Medicinal Mushrooms for Treatment of Type 2 Diabetes: An Update on Clinical Trials.
Lindequist U, Haertel B. Lindequist U, et al. Int J Med Mushrooms. 2020;22(9):845-854. doi: 10.1615/IntJMedMushrooms.2020035863. Int J Med Mushrooms. 2020. PMID: 33389851 Review.
They exist for mushrooms of the genera Agaricus, Coprinus, Ganoderma, Grifola, and Pleurotus. This article critically reviews these clinical investigations and describes which tasks need to be done to explore the potential of mushrooms for supportive treatment of type 2 di …
They exist for mushrooms of the genera Agaricus, Coprinus, Ganoderma, Grifola, and Pleurotus. This article critically reviews these c …
Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.
Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T. Wihastuti TA, et al. J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6):/j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349. J Basic Clin Physiol Pharmacol. 2020. PMID: 32031980
Background Type 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM causes advanced formation of glycation end products (AGE) which leads to oxidative stress and chronic inflammation. ...This result indicates tha …
Background Type 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM caus …
Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking.
Shi J, Chen J, Cheng C, Li W, Li M, Ye S, Liu Z, Ding Y. Shi J, et al. Curr Pharm Des. 2025 Feb 13. doi: 10.2174/0113816128365423250126035306. Online ahead of print. Curr Pharm Des. 2025. PMID: 39949090
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced insulin sensitivity in the body's cells, leading to persistently high blood glucose levels. ...This approach …
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficie …
Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats.
Chen M, Xiao D, Liu W, Song Y, Zou B, Li L, Li P, Cai Y, Liu D, Liao Q, Xie Z. Chen M, et al. Int J Biol Macromol. 2020 Jul 15;155:890-902. doi: 10.1016/j.ijbiomac.2019.11.047. Epub 2019 Nov 9. Int J Biol Macromol. 2020. PMID: 31712153
Ganoderma lucidum polysaccharides (GLP), a kind of medicinal mushrooms, were widely used in southeastern countries with putative anti-diabetic effects. In order to unravel the underlying mechanism of its anti-diabetic effect, this study examines the effects of GLP on gut m …
Ganoderma lucidum polysaccharides (GLP), a kind of medicinal mushrooms, were widely used in southeastern countries with putative anti …
Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model.
Heriansyah T, Nurwidyaningtyas W, Sargowo D, Tjahjono CT, Wihastuti TA. Heriansyah T, et al. Vasc Health Risk Manag. 2019 Oct 3;15:419-427. doi: 10.2147/VHRM.S205996. eCollection 2019. Vasc Health Risk Manag. 2019. PMID: 31632046 Free PMC article.
This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through an increase of circulating endothelial cells and circulating endothelial cells (CEC) ratio, decreased H2O2, triglyceride (TG), total cholesterol ( …
This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through an inc …
A Polysaccharide from Ganoderma atrum Improves Liver Function in Type 2 Diabetic Rats via Antioxidant Action and Short-Chain Fatty Acids Excretion.
Zhu KX, Nie SP, Tan LH, Li C, Gong DM, Xie MY. Zhu KX, et al. J Agric Food Chem. 2016 Mar 9;64(9):1938-44. doi: 10.1021/acs.jafc.5b06103. Epub 2016 Feb 29. J Agric Food Chem. 2016. PMID: 26898215
The present study was to evaluate the beneficial effect of polysaccharide isolated from Ganoderma atrum (PSG-1) on liver function in type 2 diabetic rats. Results showed that PSG-1 decreased the activities of serum aspartate aminotransferase (AST) and alanine aminotransfer …
The present study was to evaluate the beneficial effect of polysaccharide isolated from Ganoderma atrum (PSG-1) on liver function in …
Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats.
Wang F, Zhou Z, Ren X, Wang Y, Yang R, Luo J, Strappe P. Wang F, et al. Lipids Health Dis. 2015 May 22;14:49. doi: 10.1186/s12944-015-0045-y. Lipids Health Dis. 2015. PMID: 25994182 Free PMC article.
BACKGROUND: The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to the date, there is no detailed study for describing the effect of G. lucidum spores on oxidative stress, blood glucose level and lipid compositions …
BACKGROUND: The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to the dat …
Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice.
Xiao C, Wu QP, Cai W, Tan JB, Yang XB, Zhang JM. Xiao C, et al. Arch Pharm Res. 2012 Oct;35(10):1793-801. doi: 10.1007/s12272-012-1012-z. Epub 2012 Nov 9. Arch Pharm Res. 2012. PMID: 23139131
Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administered for 7 days in type 2 diabetic mice. ...
Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administer …
Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain.
Xuan M, Okazaki M, Iwata N, Asano S, Kamiuchi S, Matsuzaki H, Sakamoto T, Miyano Y, Iizuka H, Hibino Y. Xuan M, et al. Evid Based Complement Alternat Med. 2015;2015:865986. doi: 10.1155/2015/865986. Epub 2015 Apr 6. Evid Based Complement Alternat Med. 2015. PMID: 25945116 Free PMC article.
Type 2 diabetes mellitus has been known to increase systemic oxidative stress by chronic hyperglycemia and visceral obesity and aggravate cerebral ischemic injury. On the basis of our previous study regarding a water-soluble extract from the culture me …
Type 2 diabetes mellitus has been known to increase systemic oxidative stress by chronic hyperglycemia and visce …
39 results