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2,391 results

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Page 1
Calmodulin-Connexin Partnership in Gap Junction Channel Regulation-Calmodulin-Cork Gating Model.
Peracchia C, Leverone Peracchia LM. Peracchia C, et al. Int J Mol Sci. 2021 Dec 2;22(23):13055. doi: 10.3390/ijms222313055. Int J Mol Sci. 2021. PMID: 34884859 Free PMC article. Review.
In the past four decades numerous findings have indicated that gap junction channel gating is mediated by intracellular calcium concentrations ([Ca(2+)(i)]) in the high nanomolar range via calmodulin (CaM). ...X-ray diffraction data demonstrate that isolated …
In the past four decades numerous findings have indicated that gap junction channel gating is mediated by intracellular …
Accessing gap-junction channel structure-function relationships through molecular modeling and simulations.
Villanelo F, Escalona Y, Pareja-Barrueto C, Garate JA, Skerrett IM, Perez-Acle T. Villanelo F, et al. BMC Cell Biol. 2017 Jan 17;18(Suppl 1):5. doi: 10.1186/s12860-016-0121-9. BMC Cell Biol. 2017. PMID: 28124624 Free PMC article. Review.
BACKGROUND: Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other metabolites. ...
BACKGROUND: Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells …
Gap junctions.
Nielsen MS, Axelsen LN, Sorgen PL, Verma V, Delmar M, Holstein-Rathlou NH. Nielsen MS, et al. Compr Physiol. 2012 Jul;2(3):1981-2035. doi: 10.1002/cphy.c110051. Compr Physiol. 2012. PMID: 23723031 Free PMC article. Review.
Gap junctions are essential to the function of multicellular animals, which require a high degree of coordination between cells. ...Given the diversity of gap junction physiology, regulation of gap junction activity is complex. The …
Gap junctions are essential to the function of multicellular animals, which require a high degree of coordination between cell …
Calmodulin-Cork Model of Gap Junction Channel Gating-One Molecule, Two Mechanisms.
Peracchia C. Peracchia C. Int J Mol Sci. 2020 Jul 13;21(14):4938. doi: 10.3390/ijms21144938. Int J Mol Sci. 2020. PMID: 32668628 Free PMC article. Review.
The Calmodulin-Cork gating model is based on evidence for the direct role of calmodulin (CaM) in channel gating. Indeed, chemical gating of cell-to-cell channels is sensitive to nanomolar cytosolic calcium concentrations [Ca(2+)](i). ...Repeated transjunctional volt …
The Calmodulin-Cork gating model is based on evidence for the direct role of calmodulin (CaM) in channel gating. Indeed, chemical gat …
Hexadecameric structure of an invertebrate gap junction channel.
Oshima A, Matsuzawa T, Murata K, Tani K, Fujiyoshi Y. Oshima A, et al. J Mol Biol. 2016 Mar 27;428(6):1227-1236. doi: 10.1016/j.jmb.2016.02.011. Epub 2016 Feb 13. J Mol Biol. 2016. PMID: 26883891 Free article.
In contrast to the large number of structural and functional studies of connexin gap junction channels, few structural studies of recombinant innexin channels are reported. ...The three-dimensional reconstruction determined by cryo-electron crystallogr …
In contrast to the large number of structural and functional studies of connexin gap junction channels, few structural …
Structure of the gap junction channel and its implications for its biological functions.
Maeda S, Tsukihara T. Maeda S, et al. Cell Mol Life Sci. 2011 Apr;68(7):1115-29. doi: 10.1007/s00018-010-0551-z. Epub 2010 Oct 21. Cell Mol Life Sci. 2011. PMID: 20960023 Free PMC article. Review.
Gap junctions consist of arrays of intercellular channels composed of integral membrane proteins called connexin in vertebrates. Gap junction channels regulate the passage of ions and biological molecules between adjacent cells and, there …
Gap junctions consist of arrays of intercellular channels composed of integral membrane proteins called connexin in ver …
Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease.
Cottrell GT, Burt JM. Cottrell GT, et al. Biochim Biophys Acta. 2005 Jun 10;1711(2):126-41. doi: 10.1016/j.bbamem.2004.11.013. Epub 2004 Dec 8. Biochim Biophys Acta. 2005. PMID: 15955298 Free article. Review.
Definitive evidence that heterogeneous gap junction channels differentially regulate electrical conduction in excitable cells is absent. This review examines the prevalence, regulation, and implications of gap junction channel hetero-olig …
Definitive evidence that heterogeneous gap junction channels differentially regulate electrical conduction in excitable …
Connexin phosphorylation as a regulatory event linked to gap junction channel assembly.
Solan JL, Lampe PD. Solan JL, et al. Biochim Biophys Acta. 2005 Jun 10;1711(2):154-63. doi: 10.1016/j.bbamem.2004.09.013. Epub 2004 Oct 12. Biochim Biophys Acta. 2005. PMID: 15955300 Free article. Review.
Phosphorylation has been implicated in the regulation of gap junctional communication at several stages of the cell cycle and the connexin "lifecycle", such as trafficking, assembly/disassembly, degradation, as well as in the gating of "hemi" channels or intact g …
Phosphorylation has been implicated in the regulation of gap junctional communication at several stages of the cell cycle and the con …
Selective inhibition of gap junction channel activity by synthetic peptides.
Kwak BR, Jongsma HJ. Kwak BR, et al. J Physiol. 1999 May 1;516 ( Pt 3)(Pt 3):679-85. doi: 10.1111/j.1469-7793.1999.0679u.x. J Physiol. 1999. PMID: 10200417 Free PMC article.
The aim of this study was to inhibit specifically one type of gap junction channel in cells expressing multiple connexins (Cx) using synthetic oligopeptides. 2. ...Competition assays using synthetic oligopeptides may help to resolve the regulatory properties …
The aim of this study was to inhibit specifically one type of gap junction channel in cells expressing multiple connexi …
Precise control of ion channel and gap junction expression is required for patterning of the regenerating axolotl limb.
Sousounis K, Erdogan B, Levin M, Whited JL. Sousounis K, et al. Int J Dev Biol. 2020;64(10-11-12):485-494. doi: 10.1387/ijdb.200114jw. Int J Dev Biol. 2020. PMID: 33200809 Free PMC article.
It is not, however, known whether regulators of a cell's ionic state are involved in limb patterning at later stages of regeneration. Here we manipulated expression and activities of ion channels and gap junctions in vivo, in axolotl limb blastema cell …
It is not, however, known whether regulators of a cell's ionic state are involved in limb patterning at later stages of regeneration. Here w …
2,391 results