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Page 1
Gap junction gene and protein families: Connexins, innexins, and pannexins.
Beyer EC, Berthoud VM. Beyer EC, et al. Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):5-8. doi: 10.1016/j.bbamem.2017.05.016. Epub 2017 May 27. Biochim Biophys Acta Biomembr. 2018. PMID: 28559187 Free PMC article. Review.
Gap junction channels facilitate the intercellular exchange of ions and small molecules. While this process is critical to all multicellular organisms, the proteins that form gap junction channels are not conserved. Vertebrate gap junctions are …
Gap junction channels facilitate the intercellular exchange of ions and small molecules. While this process is critical to all …
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease.
Xiang Q, Liu XL, Chen JJ, Yang L, Liu LN, Deng J, Tao JS, Li XH. Xiang Q, et al. Protein Pept Lett. 2023;30(11):891-899. doi: 10.2174/0109298665269246231023104904. Protein Pept Lett. 2023. PMID: 37974440 Review.
Gap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many geneti …
Gap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in a …
The role of the gap junction protein connexin32 in the pathogenesis of X-linked Charcot-Marie-Tooth disease.
Scherer SS, Bone LJ, Deschênes SM, Abel A, Balice-Gordon RJ, Fischbeck KH. Scherer SS, et al. Novartis Found Symp. 1999;219:175-85; discussion 185-7. doi: 10.1002/9780470515587.ch11. Novartis Found Symp. 1999. PMID: 10207904 Review.
Mutations in the gene encoding the gap junction protein connexin32 (Cx32; beta 1) cause the X-linked form of Charcot-Marie-Tooth disease (CMTX), a common form of inherited demyelinating neuropathy. ...In transfected cells different CMTX mutations have differe …
Mutations in the gene encoding the gap junction protein connexin32 (Cx32; beta 1) cause the X-linked form of Charcot-Ma …
Gap Junction Protein Connexin 43 as a Target Is Internalized in Astrocyte Neurotoxicity Caused by Di-(2-ethylhexyl) Phthalate.
Zhao YX, Tang YX, Sun XH, Zhu SY, Dai XY, Li XN, Li JL. Zhao YX, et al. J Agric Food Chem. 2022 May 18;70(19):5921-5931. doi: 10.1021/acs.jafc.2c01635. Epub 2022 Apr 21. J Agric Food Chem. 2022. PMID: 35446567
Of note, integrated immunofluorescent codetection approaches revealed an overexpression of the glial fibrillary acidic protein (GFAP) and down-expression of Cx43 in astrocytes. Therefore, in terms of neurotoxicity, this experiment in vivo models directly linked Cx43 intern …
Of note, integrated immunofluorescent codetection approaches revealed an overexpression of the glial fibrillary acidic protein (GFAP) …
Evolutionary analyses of gap junction protein families.
Abascal F, Zardoya R. Abascal F, et al. Biochim Biophys Acta. 2013 Jan;1828(1):4-14. doi: 10.1016/j.bbamem.2012.02.007. Epub 2012 Feb 14. Biochim Biophys Acta. 2013. PMID: 22366062 Free article. Review.
Two different protein families, pannexins and connexins, form these channels. Pannexins are present in all eumetazoans but echinoderms (and are termed innexins in non-chordates) whereas connexins are exclusive of chordates. Despite little sequence similarity, …
Two different protein families, pannexins and connexins, form these channels. Pannexins are present in all eumetazoans but ech …
Single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among Epstein-Barr virus-associated tumors.
Xiao H, Liu W, Zhao Z, Zhang Y, Song Y, Luo B. Xiao H, et al. Cancer Biomark. 2018 Feb 14;21(3):499-504. doi: 10.3233/CBM-170078. Cancer Biomark. 2018. PMID: 29103018 Free article. Review.
BACKGROUND: Gap junction protein beta 2 gene (GJB2) encodes one of connexins- Connexin 26 (Cx26), which mainly expressed in epithelial cells. ...
BACKGROUND: Gap junction protein beta 2 gene (GJB2) encodes one of connexins- Connexin 26 (Cx26), which mainly e …
Does astrocyte gap junction protein expression differ during development in absence epileptic rats?
Köse B, Özkan M, Sur-Erdem İ, Çavdar S. Köse B, et al. Synapse. 2022 Mar;76(3-4):e22225. doi: 10.1002/syn.22225. Epub 2022 Feb 18. Synapse. 2022. PMID: 35137459
Intercellular communication via gap junctions (GJs) has a wide variety of complex and essential functions in the CNS. In the present developmental study, we aimed to quantify the number of astrocytic GJs protein connexin 30 (Cx30) of genetic model of absence epileps …
Intercellular communication via gap junctions (GJs) has a wide variety of complex and essential functions in the CNS. In the present …
The gap junction protein connexin 43 controls multiple aspects of cranial neural crest cell development.
Jourdeuil K, Taneyhill LA. Jourdeuil K, et al. J Cell Sci. 2020 Feb 20;133(4):jcs235440. doi: 10.1242/jcs.235440. J Cell Sci. 2020. PMID: 31964703 Free PMC article.
Connexin 43 (Cx43; also known as GJA1), the predominant gap junction protein in vertebrates, is expressed in premigratory cranial neural crest cells and is maintained throughout the neural crest cell epithelial-to-mesenchymal transition (EMT), but its functio …
Connexin 43 (Cx43; also known as GJA1), the predominant gap junction protein in vertebrates, is expressed in premigrato …
Gap junction channels: from protein genes to diseases.
Hervé JC. Hervé JC. Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):1-4. doi: 10.1016/j.pbiomolbio.2007.03.012. Epub 2007 Mar 19. Prog Biophys Mol Biol. 2007. PMID: 17467044 Free article. No abstract available.
The innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function.
Fuenzalida-Uribe N, Hidalgo S, Silva B, Gandhi S, Vo D, Zamani P, Holmes TC, Sayin S, Grunwald Kadow IC, Hadjieconomou D, O'Dowd DK, Campusano JM. Fuenzalida-Uribe N, et al. Front Neural Circuits. 2025 Apr 25;19:1563401. doi: 10.3389/fncir.2025.1563401. eCollection 2025. Front Neural Circuits. 2025. PMID: 40352759 Free PMC article.
The invertebrate gap junction protein ShakB contributes to electrical synapses between AL projection neurons (PNs) in Drosophila. Other gap junction proteins, including innexin 7 (Inx7), are also expressed in the Drosophila AL, but little is kno …
The invertebrate gap junction protein ShakB contributes to electrical synapses between AL projection neurons (PNs) in D …
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