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Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

Loan Nguyen TM, Guilloux JP, Defaix C, Mendez-David I, Etting I, Alvarez JC, McGowan JC, Highland JN, Zanos P, Lovett J, Moaddel R, Corruble E, David DJ, Gould TD, Denny CA, Gardier AM. Loan Nguyen TM, et al. Neuropharmacology. 2024 Nov 1;258:110065. doi: 10.1016/j.neuropharm.2024.110065. Epub 2024 Jul 14. Neuropharmacology. 2024. PMID: 39004413 Free PMC article.

[Ketamine: a neuropsychotropic drug with an innovative mechanism of action].

Guilloux JP, Nguyen TML, Gardier AM. Guilloux JP, et al. Biol Aujourdhui. 2023;217(3-4):133-144. doi: 10.1051/jbio/2023026. Epub 2023 Nov 29. Biol Aujourdhui. 2023. PMID: 38018940 Review. French.

[Ketamine and suicidal behavior: Contribution of animal models of aggression-impulsivity to understanding its mechanism of action].

Nguyen TML, Jollant F, Tritschler L, Colle R, Corruble E, Gardier AM. Nguyen TML, et al. Ann Pharm Fr. 2024 Jan;82(1):3-14. doi: 10.1016/j.pharma.2023.10.008. Epub 2023 Oct 27. Ann Pharm Fr. 2024. PMID: 37890717 Review. French.

A tale of two receptors: simultaneous targeting of NMDARs and 5-HT ₄ Rs exerts additive effects against stress.

Chen BK, Luna VM, Jin M, Shah A, Shannon ME, Pauers M, Williams BL, Pham V, Hunsberger HC, Gardier AM, Mendez-David I, David DJ, Denny CA. Chen BK, et al. bioRxiv [Preprint]. 2023 Sep 27:2023.09.27.559065. doi: 10.1101/2023.09.27.559065. bioRxiv. 2023. PMID: 37808799 Free PMC article. Preprint.

A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin.

Mendez-David I, David DJ, Deloménie C, Tritschler L, Beaulieu JM, Colle R, Corruble E, Gardier AM, Hen R. Mendez-David I, et al. Hippocampus. 2023 Oct;33(10):1075-1093. doi: 10.1002/hipo.23568. Epub 2023 Jul 8. Hippocampus. 2023. PMID: 37421207

Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25-6981, increases glutamate neurotransmission and induces antidepressant-like effects.

Doan J, Defaix C, Mendez-David I, Gardier AM, Colle R, Corruble E, McGowan JC, David DJ, Guilloux JP, Tritschler L. Doan J, et al. Fundam Clin Pharmacol. 2023 Dec;37(6):1119-1128. doi: 10.1111/fcp.12917. Epub 2023 Jun 1. Fundam Clin Pharmacol. 2023. PMID: 37161789

Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review.

Nguyen TML, Jollant F, Tritschler L, Colle R, Corruble E, Gardier AM. Nguyen TML, et al. Pharmaceuticals (Basel). 2023 Apr 21;16(4):634. doi: 10.3390/ph16040634. Pharmaceuticals (Basel). 2023. PMID: 37111391 Free PMC article. Review.

Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review.

Jollant F, Colle R, Nguyen TML, Corruble E, Gardier AM, Walter M, Abbar M, Wagner G. Jollant F, et al. Ther Adv Psychopharmacol. 2023 Feb 7;13:20451253231151327. doi: 10.1177/20451253231151327. eCollection 2023. Ther Adv Psychopharmacol. 2023. PMID: 36776623 Free PMC article. Review.

Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity.

Nguyen TML, Defaix C, Mendez-David I, Tritschler L, Etting I, Alvarez JC, Choucha W, Colle R, Corruble E, David DJ, Gardier AM. Nguyen TML, et al. Neuropharmacology. 2023 Mar 1;225:109357. doi: 10.1016/j.neuropharm.2022.109357. Epub 2022 Nov 30. Neuropharmacology. 2023. PMID: 36462636

Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.

Lebeau RH, Mendez-David I, Kucynski-Noyau L, Henry C, Attali D, Plaze M, Colle R, Corruble E, Gardier AM, Gaillard R, Guilloux JP, David DJ. Lebeau RH, et al. Front Pharmacol. 2022 Oct 31;13:993449. doi: 10.3389/fphar.2022.993449. eCollection 2022. Front Pharmacol. 2022. PMID: 36386166 Free PMC article.

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