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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 17
1947 4
1948 9
1949 7
1950 12
1951 27
1952 26
1953 23
1954 16
1955 31
1956 32
1957 36
1958 40
1959 49
1960 69
1961 56
1962 54
1963 38
1964 44
1965 49
1966 8
1967 11
1968 29
1969 27
1970 28
1971 59
1972 67
1973 114
1974 96
1975 174
1976 225
1977 168
1978 174
1979 230
1980 220
1981 247
1982 279
1983 304
1984 381
1985 440
1986 441
1987 480
1988 520
1989 790
1990 1065
1991 1243
1992 1624
1993 2446
1994 2663
1995 3474
1996 3908
1997 4556
1998 5247
1999 6156
2000 7449
2001 7979
2002 8959
2003 9927
2004 10684
2005 12170
2006 13054
2007 13833
2008 15288
2009 16093
2010 18244
2011 20097
2012 21868
2013 23799
2014 26108
2015 28393
2016 28843
2017 29792
2018 30552
2019 31886
2020 34775
2021 31313
2022 1216
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432,628 results
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Page 1
Gene Therapy for Neurodegenerative Diseases.
Sudhakar V, Richardson RM. Sudhakar V, et al. Neurotherapeutics. 2019 Jan;16(1):166-175. doi: 10.1007/s13311-018-00694-0. Neurotherapeutics. 2019. PMID: 30542906 Free PMC article. Review.
Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases through several means, including direct correction of pathogenic mechanisms, neuroprotection, neurorestoration, and symptom control. ...The gene …
Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases through se …
Nonintegrating Gene Therapy Vectors.
Athanasopoulos T, Munye MM, Yáñez-Muñoz RJ. Athanasopoulos T, et al. Hematol Oncol Clin North Am. 2017 Oct;31(5):753-770. doi: 10.1016/j.hoc.2017.06.007. Hematol Oncol Clin North Am. 2017. PMID: 28895845 Free article. Review.
Gene delivery vectors that do not rely on host cell genome integration offer several advantages for gene transfer, chiefly the avoidance of insertional mutagenesis and position effect variegation. ...This article provides an overview of the main nonintegrating viral …
Gene delivery vectors that do not rely on host cell genome integration offer several advantages for gene transfer, chiefly the …
[Gene therapy - from idea to reality].
Smith CIE, Blomberg P. Smith CIE, et al. Lakartidningen. 2017 Dec 19;114:EWYL. Lakartidningen. 2017. PMID: 29297925 Free article. Review. Swedish.
Gene therapy - from idea to reality Gene therapy was originally proposed 45 years ago, but it is only during the last 5-10 years that significant clinical benefit has been demonstrated. Gene therapy is in most cases in the form of enginee …
Gene therapy - from idea to reality Gene therapy was originally proposed 45 years ago, but it is only during the …
History of gene therapy.
Wirth T, Parker N, Ylä-Herttuala S. Wirth T, et al. Gene. 2013 Aug 10;525(2):162-9. doi: 10.1016/j.gene.2013.03.137. Epub 2013 Apr 23. Gene. 2013. PMID: 23618815 Review.
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. ...In this review, we will take a historical view and highlight some of the milestones that had an important impact on the development of gene therapy. We will also …
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. ...In this review, we will take a hist …
Gene therapy on the move.
Kaufmann KB, Büning H, Galy A, Schambach A, Grez M. Kaufmann KB, et al. EMBO Mol Med. 2013 Nov;5(11):1642-61. doi: 10.1002/emmm.201202287. Epub 2013 Sep 17. EMBO Mol Med. 2013. PMID: 24106209 Free PMC article. Review.
The first gene therapy clinical trials were initiated more than two decades ago. ...With more than 1900 clinical trials to date, gene therapy has moved from a vision to clinical reality. This review focuses on the application of gene therapy …
The first gene therapy clinical trials were initiated more than two decades ago. ...With more than 1900 clinical trials to dat …
[Gene therapy for retinitis pigmentosa].
Ducloyer JB, Le Meur G, Cronin T, Adjali O, Weber M. Ducloyer JB, et al. Med Sci (Paris). 2020 Jun-Jul;36(6-7):607-615. doi: 10.1051/medsci/2020095. Epub 2020 Jul 2. Med Sci (Paris). 2020. PMID: 32614312 Free article. Review. French.
Retinitis pigmentosa is the most common blinding inherited retinal dystrophy. Gene therapy is a burgeoning revolutionary approach that paves the way to treatment of previously incurable diseases. ...This treatment, with proven efficacy, is available to patients with …
Retinitis pigmentosa is the most common blinding inherited retinal dystrophy. Gene therapy is a burgeoning revolutionary appro …
Gene therapy.
Brody H. Brody H. Nature. 2018 Dec;564(7735):S5. doi: 10.1038/d41586-018-07639-9. Nature. 2018. PMID: 30542191 No abstract available.
A brief history of gene therapy.
Friedmann T. Friedmann T. Nat Genet. 1992 Oct;2(2):93-8. doi: 10.1038/ng1092-93. Nat Genet. 1992. PMID: 1303270 Review.
The concepts of gene therapy arose initially during the 1960s and early 1970s whilst the development of genetically marked cells lines and the clarification of mechanisms of cell transformation by the papaovaviruses polyoma and SV40 was in progress. ...Efficient ret …
The concepts of gene therapy arose initially during the 1960s and early 1970s whilst the development of genetically marked cel …
Gene therapy: a double-edged sword with great powers.
Tang R, Xu Z. Tang R, et al. Mol Cell Biochem. 2020 Nov;474(1-2):73-81. doi: 10.1007/s11010-020-03834-3. Epub 2020 Jul 21. Mol Cell Biochem. 2020. PMID: 32696132 Review.
Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. ...However, concerns about its efficacy and safety have accompanied gene therapy since its birth. In the present manuscript, we first in …
Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. ...However …
Gene therapy of hemoglobinopathies: progress and future challenges.
Ikawa Y, Miccio A, Magrin E, Kwiatkowski JL, Rivella S, Cavazzana M. Ikawa Y, et al. Hum Mol Genet. 2019 Oct 1;28(R1):R24-R30. doi: 10.1093/hmg/ddz172. Hum Mol Genet. 2019. PMID: 31322165 Review.
Recently, gene therapy clinical trials have been successfully applied to hemoglobinopathies, such as sickle cell disease (SCD) and beta-thalassemia. ...In this review, we summarize these gene therapy strategies and ongoing clinical trials. Finally, we …
Recently, gene therapy clinical trials have been successfully applied to hemoglobinopathies, such as sickle cell disease (SCD) …
432,628 results
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