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1991 1
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2001 11
2002 8
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2008 11
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2010 5
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154 results
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Genistein alleviates atherosclerosis in apolipoprotein E-deficient mice by interrupting the OX40/OX40L pathway.
Wei J, Yao Z, Li H, Lin J, Cui Z, Zhang L. Wei J, et al. Int J Clin Exp Pathol. 2019 May 1;12(5):1658-1665. eCollection 2019. Int J Clin Exp Pathol. 2019. PMID: 31933984 Free PMC article.
This study aims to explore the effect and the underlying mechanisms of genistein on the development of atherosclerosis in apolipoprotein E gene knockout (ApoE(-/-)) mice. ...These results suggest that genistein potentially has atheroprotective effects that in …
This study aims to explore the effect and the underlying mechanisms of genistein on the development of atherosclerosis in apol …
Effect of Genistein on Cholesterol Metabolism-Related Genes in HepG2 Cell.
Lu R, Zheng Z, Yin Y, Jiang Z. Lu R, et al. J Food Sci. 2019 Aug;84(8):2330-2336. doi: 10.1111/1750-3841.14725. Epub 2019 Jul 17. J Food Sci. 2019. PMID: 31313321
It has been reported that genistein could improve metabolic syndromes. Our study aimed to investigate the effects and potential mechanisms of genistein on improving cholesterol metabolism in HepG2 cell. ...In addition, plasma cholesterol is regarded as the key indic …
It has been reported that genistein could improve metabolic syndromes. Our study aimed to investigate the effects and potential mecha …
Soy foods, isoflavones, and the health of postmenopausal women.
Messina M. Messina M. Am J Clin Nutr. 2014 Jul;100 Suppl 1:423S-30S. doi: 10.3945/ajcn.113.071464. Epub 2014 Jun 4. Am J Clin Nutr. 2014. PMID: 24898224
In addition, soflavones improve endothelial function and possibly slow the progression of subclinical atherosclerosis. Isoflavone supplements also consistently alleviate menopausal hot flashes provided they contain sufficient amounts of the predominant soybean isoflavone …
In addition, soflavones improve endothelial function and possibly slow the progression of subclinical atherosclerosis. Isoflavone sup …
Genistein supplementation inhibits atherosclerosis with stabilization of the lesions in hypercholesterolemic rabbits.
Lee CS, Kwon SJ, Na SY, Lim SP, Lee JH. Lee CS, et al. J Korean Med Sci. 2004 Oct;19(5):656-61. doi: 10.3346/jkms.2004.19.5.656. J Korean Med Sci. 2004. PMID: 15483339 Free PMC article.
The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and western blotting for matrix metalloproteinase-3 (MMP-3) in New Zealand White rabbits. After provocation of atherosclerosis with hyperli …
The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and we …
Soy Isoflavones Inhibit Endothelial Cell Dysfunction and Prevent Cardiovascular Disease.
Yamagata K. Yamagata K. J Cardiovasc Pharmacol. 2019 Sep;74(3):201-209. doi: 10.1097/FJC.0000000000000708. J Cardiovasc Pharmacol. 2019. PMID: 31356541 Review.
Soy is a rich dietary source of isoflavones. The main soy isoflavones are daidzein and genistein; equol, another isoflavone and a major intestinal bacterial metabolite of daidzein, is generated by enterobacterial effects. ...Furthermore, it describes the beneficial roles t …
Soy is a rich dietary source of isoflavones. The main soy isoflavones are daidzein and genistein; equol, another isoflavone and a maj …
Phytochemical genistein in the regulation of vascular function: new insights.
Si H, Liu D. Si H, et al. Curr Med Chem. 2007;14(24):2581-9. doi: 10.2174/092986707782023325. Curr Med Chem. 2007. PMID: 17979711 Review.
Data from animal and in vitro studies suggest a protective role of genistein in cardiovascular events. However, the mechanisms of the genistein action on vascular protective effects are unclear. Past extensive studies exploring its hypolipidemic effect resulted in c …
Data from animal and in vitro studies suggest a protective role of genistein in cardiovascular events. However, the mechanisms of the …
Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs.
Zhang HP, Zhao JH, Yu HX, Guo DX. Zhang HP, et al. Environ Toxicol Pharmacol. 2016 Mar;42:118-24. doi: 10.1016/j.etap.2016.01.011. Epub 2016 Jan 16. Environ Toxicol Pharmacol. 2016. PMID: 26829290
Endothelial nitric oxidase synthase (eNOS) uncoupling plays a causal role in endothelial dysfunction in atherosclerosis. Genistein consumption has been associated with the prevention of atherosclerosis. ...Accompanied with genistein ameliorating eNOS u …
Endothelial nitric oxidase synthase (eNOS) uncoupling plays a causal role in endothelial dysfunction in atherosclerosis. Genistein …
Genistein Protects Against Ox-LDL-Induced Inflammation Through MicroRNA-155/SOCS1-Mediated Repression of NF-qB Signaling Pathway in HUVECs.
Zhang H, Zhao Z, Pang X, Yang J, Yu H, Zhang Y, Zhou H, Zhao J. Zhang H, et al. Inflammation. 2017 Aug;40(4):1450-1459. doi: 10.1007/s10753-017-0588-3. Inflammation. 2017. PMID: 28550396
Genistein plays an important role in the prevention of atherosclerosis. ...Further analyses demonstrated the effect of genistein was associated with reducing miR-155 and elevating SOCS1, and miR-155 mimics or SOCS1 siRNA acted similarly in genistein am …
Genistein plays an important role in the prevention of atherosclerosis. ...Further analyses demonstrated the effect of geni …
Genistein inhibits the development of atherosclerosis via inhibiting NF-kappaB and VCAM-1 expression in LDLR knockout mice.
Wang J, Zhang R, Xu Y, Zhou H, Wang B, Li S. Wang J, et al. Can J Physiol Pharmacol. 2008 Nov;86(11):777-84. doi: 10.1139/Y08-085. Can J Physiol Pharmacol. 2008. PMID: 19011673
Here, we explored the effect of genistein in atherosclerosis (AS) development in an in vivo mouse model. ...Genistein had no influence, however, on serum cholesterol and lipid profiles. ...
Here, we explored the effect of genistein in atherosclerosis (AS) development in an in vivo mouse model. ...Genistein h …
7-Difluoromethyl-5,4'-dimethoxygenistein, a novel genistein derivative, has therapeutic effects on atherosclerosis in a rabbit model.
Zhao H, Li C, Cao JG, Xiang HL, Yang HZ, You JL, Li CL, Fu XH. Zhao H, et al. J Cardiovasc Pharmacol. 2009 Nov;54(5):412-20. doi: 10.1097/FJC.0b013e3181bad280. J Cardiovasc Pharmacol. 2009. PMID: 19730393
However, it exhibits poor bioavailability, which limits the use of genistein to treat cardiovascular and cerebrovascular diseases. A novel genistein derivative, 7-difluoromethyl-5,4'-dimethoxygenistein (dFMGEN), has shown a better protective effect on vascular endot …
However, it exhibits poor bioavailability, which limits the use of genistein to treat cardiovascular and cerebrovascular diseases. A …
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