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180 results

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Page 1
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.
Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. Wei TT, et al. Cell. 2022 May 12;185(10):1676-1693.e23. doi: 10.1016/j.cell.2022.04.005. Epub 2022 Apr 29. Cell. 2022. PMID: 35489334 Free PMC article.
Knockdown of the CB1 receptor with siRNA, CRISPR interference, and genistein attenuated the effects of delta(9)-THC. In mice, genistein blocked delta(9)-THC-induced endothelial dysfunction in wire myograph, reduced atherosclerotic plaque, and had minimal penetration …
Knockdown of the CB1 receptor with siRNA, CRISPR interference, and genistein attenuated the effects of delta(9)-THC. In mice, geni …
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARgamma-LXRalpha-ABCA1/ABCG1 pathway.
Zheng S, Huang H, Li Y, Wang Y, Zheng Y, Liang J, Zhang S, Liu M, Fang Z. Zheng S, et al. Pharmacol Res. 2021 Jul;169:105639. doi: 10.1016/j.phrs.2021.105639. Epub 2021 Apr 28. Pharmacol Res. 2021. PMID: 33932607
Atherosclerosis is now the major cause of mortality and morbidity worldwide. Formation of macrophage-derived foam cells is a hallmark of atherosclerosis, which is regulated by cholesterol uptake, intracellular metabolism, and efflux. ...Many traditional Chinese medi …
Atherosclerosis is now the major cause of mortality and morbidity worldwide. Formation of macrophage-derived foam cells is a hallmark …
Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.
Duan H, Zhang Q, Liu J, Li R, Wang D, Peng W, Wu C. Duan H, et al. Pharmacol Res. 2021 Jun;168:105599. doi: 10.1016/j.phrs.2021.105599. Epub 2021 Apr 7. Pharmacol Res. 2021. PMID: 33838291 Review.
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the predominant causes of death worldwide. ...Currently, accumulating evidence has revealed that endothelial cell apoptosis is the first step o …
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the …
Genistein alleviates atherosclerosis in apolipoprotein E-deficient mice by interrupting the OX40/OX40L pathway.
Wei J, Yao Z, Li H, Lin J, Cui Z, Zhang L. Wei J, et al. Int J Clin Exp Pathol. 2019 May 1;12(5):1658-1665. eCollection 2019. Int J Clin Exp Pathol. 2019. PMID: 31933984 Free PMC article.
This study aims to explore the effect and the underlying mechanisms of genistein on the development of atherosclerosis in apolipoprotein E gene knockout (ApoE(-/-)) mice. ...These results suggest that genistein potentially has atheroprotective effects that in …
This study aims to explore the effect and the underlying mechanisms of genistein on the development of atherosclerosis in apol …
Flavonoids as Potential Anti-Inflammatory Molecules: A Review.
Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Al-Khayri JM, et al. Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. Molecules. 2022. PMID: 35566252 Free PMC article. Review.
They inhibit the secretions of enzymes such as lysozymes and beta-glucuronidase and inhibit the secretion of arachidonic acid, which reduces inflammatory reactions. Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the e …
They inhibit the secretions of enzymes such as lysozymes and beta-glucuronidase and inhibit the secretion of arachidonic acid, which reduces …
Genistein: A Review on its Anti-Inflammatory Properties.
Goh YX, Jalil J, Lam KW, Husain K, Premakumar CM. Goh YX, et al. Front Pharmacol. 2022 Jan 24;13:820969. doi: 10.3389/fphar.2022.820969. eCollection 2022. Front Pharmacol. 2022. PMID: 35140617 Free PMC article. Review.
In the past, numerous in vitro and in vivo studies have been conducted to investigate the anti-inflammatory potential of genistein. Henceforth, this review aims to summarize the anti-inflammatory properties of genistein linking with the signaling pathways and mediat …
In the past, numerous in vitro and in vivo studies have been conducted to investigate the anti-inflammatory potential of genistein. H …
Flavonoids and their role in oxidative stress, inflammation, and human diseases.
Jomova K, Alomar SY, Valko R, Liska J, Nepovimova E, Kuca K, Valko M. Jomova K, et al. Chem Biol Interact. 2025 May 25;413:111489. doi: 10.1016/j.cbi.2025.111489. Epub 2025 Mar 25. Chem Biol Interact. 2025. PMID: 40147618 Free article. Review.
Oxidative stress and chronic inflammation are important drivers in the pathogenesis and progression of many chronic diseases, such as cancers of the breast, kidney, lung, and others, autoimmune diseases (rheumatoid arthritis), cardiovascular diseases (hypertension, atheroscler …
Oxidative stress and chronic inflammation are important drivers in the pathogenesis and progression of many chronic diseases, such as cancer …
Genistein supplementation inhibits atherosclerosis with stabilization of the lesions in hypercholesterolemic rabbits.
Lee CS, Kwon SJ, Na SY, Lim SP, Lee JH. Lee CS, et al. J Korean Med Sci. 2004 Oct;19(5):656-61. doi: 10.3346/jkms.2004.19.5.656. J Korean Med Sci. 2004. PMID: 15483339 Free PMC article.
The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and western blotting for matrix metalloproteinase-3 (MMP-3) in New Zealand White rabbits. After provocation of atherosclerosis with hyperli …
The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and we …
Genistein ameliorates thoracic aortic dissection by inhibiting CB1 receptor hyperactivation and modulating its-mediated cAMP-PKA signaling.
Chi Y, Huang T, Zhao J, Huang Y, Zhou Z, Xing B, Qu D, Sun J, Fu Y, Yu L, Wang H, Jiang H. Chi Y, et al. Phytomedicine. 2025 Nov;147:157178. doi: 10.1016/j.phymed.2025.157178. Epub 2025 Aug 16. Phytomedicine. 2025. PMID: 40845589
Cannabinoid 1 (CB1/Cnr1) receptor has been implicated in cardiovascular diseases, but its role in TAD and its downstream signaling remains unclear. Genistein (Gen), an isoflavone abundant in legumes, has demonstrated promising therapeutic potential in cardiovascular diseas …
Cannabinoid 1 (CB1/Cnr1) receptor has been implicated in cardiovascular diseases, but its role in TAD and its downstream signaling remains u …
Effect of Genistein on Cholesterol Metabolism-Related Genes in HepG2 Cell.
Lu R, Zheng Z, Yin Y, Jiang Z. Lu R, et al. J Food Sci. 2019 Aug;84(8):2330-2336. doi: 10.1111/1750-3841.14725. Epub 2019 Jul 17. J Food Sci. 2019. PMID: 31313321
It has been reported that genistein could improve metabolic syndromes. Our study aimed to investigate the effects and potential mechanisms of genistein on improving cholesterol metabolism in HepG2 cell. ...In addition, plasma cholesterol is regarded as the key indic …
It has been reported that genistein could improve metabolic syndromes. Our study aimed to investigate the effects and potential mecha …
180 results