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64 results

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Page 1
Glycine soja Leaf and Stem Extract Ameliorates Atopic Dermatitis-like Skin Inflammation by Inhibiting JAK/STAT Signaling.
Sung YY, Kim M, Kim DS, Son E. Sung YY, et al. Int J Mol Sci. 2025 May 9;26(10):4560. doi: 10.3390/ijms26104560. Int J Mol Sci. 2025. PMID: 40429704 Free PMC article.
Using ultra-performance liquid chromatography, we identified seven flavonoids in GS extract, including apigenin, epicatechin, genistein, genistin, daidzin, daidzein, and soyasaponin Bb. GS, apigenin, and genistein reduced the expression of IL-6, MDC, T …
Using ultra-performance liquid chromatography, we identified seven flavonoids in GS extract, including apigenin, epicatechin, geni …
Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease.
Muraleedharan A, Ray SK. Muraleedharan A, et al. Brain Sci. 2024 Jan 19;14(1):96. doi: 10.3390/brainsci14010096. Brain Sci. 2024. PMID: 38275516 Free PMC article. Review.
This review is focused on two bioflavonoids, specifically epigallocatechin-3-gallate (EGCG) and genistein (GS), as a possible new paradigm of treatment for maintaining healthy gut microbiota in AD due to their implications in modulating crucial AD signaling pathways …
This review is focused on two bioflavonoids, specifically epigallocatechin-3-gallate (EGCG) and genistein (GS), as a possible …
Nimbin analogs stimulate glucose uptake and glycogen storage in the insulin signalling cascade by enhancing the IRTK, PI3K and Glut-4 mechanism in myotubes.
Sudhakaran G, Rajesh R, Almutairi BO, Arokiyaraj S, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Tissue Cell. 2023 Jun;82:102104. doi: 10.1016/j.tice.2023.102104. Epub 2023 May 6. Tissue Cell. 2023. PMID: 37207372
AIM: This study aimed to evaluate the effect of Nimbin semi-natural analogs (N2, N5, N7, and N8) from A. indica on high glucose-induced ROS and apoptosis with insulin resistance in L6 myotubes evaluated along with Wortmannin and Genistein inhibitors and the expression of k …
AIM: This study aimed to evaluate the effect of Nimbin semi-natural analogs (N2, N5, N7, and N8) from A. indica on high glucose-induced ROS …
Impacts of properties of dissolved organic matters on indirect photodegradation of genistein.
Yang C, Zhang S, Li X, Zhang X, Zhao Q, Li Y, Li H. Yang C, et al. Sci Total Environ. 2023 Apr 1;867:161448. doi: 10.1016/j.scitotenv.2023.161448. Epub 2023 Jan 6. Sci Total Environ. 2023. PMID: 36623661
In this study, roles of (3)DOM* in photodegradation of polyhydroxy phenolic genistein (Gs) at pH 5, 8 and 12 were investigated taking five kinds of DOM from different sources as examples. ...Results showed that the contributions of direct (3)DOM*-induced reactions t …
In this study, roles of (3)DOM* in photodegradation of polyhydroxy phenolic genistein (Gs) at pH 5, 8 and 12 were investigated …
Comprehensive Metabolite Profiling of Four Different Beans Fermented by Aspergillus oryzae.
Lee YH, Lee NR, Lee CH. Lee YH, et al. Molecules. 2022 Nov 16;27(22):7917. doi: 10.3390/molecules27227917. Molecules. 2022. PMID: 36432017 Free PMC article.
In contrast, isoflavone aglycones (e.g., daidzein, glycitein, and genistein) and DDMP-conjugated soyasaponins (e.g., soyasaponins betaa and gammag) were increased in GM and GS during fermentation. Notably, these metabolite changes were more significant in GS …
In contrast, isoflavone aglycones (e.g., daidzein, glycitein, and genistein) and DDMP-conjugated soyasaponins (e.g., soyasaponins bet …
Genistein attenuates memory impairment in Alzheimer's disease via ERS-mediated apoptotic pathway in vivo and in vitro.
Gao H, Lei X, Ye S, Ye T, Hua R, Wang G, Song H, Zhou P, Wang Y, Cai B. Gao H, et al. J Nutr Biochem. 2022 Nov;109:109118. doi: 10.1016/j.jnutbio.2022.109118. Epub 2022 Aug 3. J Nutr Biochem. 2022. PMID: 35933022
Genistein (GS), an isoflavone compound found in soybean, plays a neuroprotective role in Alzheimer's disease (AD). However, the mechanism of its action remains unclear. Herein, binding ability between GS and GRP78 was predicted by molecular docking, and the e …
Genistein (GS), an isoflavone compound found in soybean, plays a neuroprotective role in Alzheimer's disease (AD). However, th …
Formulation of Genistein-HP beta Cyclodextrin-Poloxamer 188 Ternary Inclusion Complex: Solubility to Cytotoxicity Assessment.
Zafar A, Alruwaili NK, Imam SS, Alsaidan OA, Alkholifi FK, Alharbi KS, Mostafa EM, Alanazi AS, Gilani SJ, Musa A, Alshehri S, Rawaf A, Alquraini A. Zafar A, et al. Pharmaceutics. 2021 Nov 24;13(12):1997. doi: 10.3390/pharmaceutics13121997. Pharmaceutics. 2021. PMID: 34959278 Free PMC article.
The current study was designed to prepare the inclusion complex Genistein (GS) using Hydroxypropyl beta cyclodextrin (HP beta CD) and poloxamer 188 (PL 188). ...The dissolution study result showed a marked increment in GS dissolution/release after incorporati …
The current study was designed to prepare the inclusion complex Genistein (GS) using Hydroxypropyl beta cyclodextrin (HP beta …
Genistein loaded into microporous surface of nano tantalum/PEEK composite with antibacterial effect regulating cellular response in vitro, and promoting osseointegration in vivo.
Luo S, Wang P, Ma M, Pan Z, Lu L, Yin F, Cai J. Luo S, et al. J Mech Behav Biomed Mater. 2022 Jan;125:104972. doi: 10.1016/j.jmbbm.2021.104972. Epub 2021 Nov 11. J Mech Behav Biomed Mater. 2022. PMID: 34794044
In this study, by blending Ta nanoparticles with PEEK, Ta/PEEK composite (TP) was prepared, which was then treated by concentrated sulfuric acid to form a microporous surface containing Ta particles on TP (TPS). Moreover, genistein (GS) with antibacterial property w …
In this study, by blending Ta nanoparticles with PEEK, Ta/PEEK composite (TP) was prepared, which was then treated by concentrated sulfuric …
Identification of Food-Derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins.
Agustina R, Masuo Y, Kido Y, Shinoda K, Ishimoto T, Kato Y. Agustina R, et al. Drug Metab Dispos. 2021 Nov;49(11):972-984. doi: 10.1124/dmd.121.000534. Epub 2021 Aug 19. Drug Metab Dispos. 2021. PMID: 34413161
Plasma peaks of food-derived isoflavone metabolites, daidzein sulfate (DS), and genistein sulfate (GS) increased after lapatinib administration and in Bcrp (-/-) mice. Administration of lapatinib and another BCRP inhibitor febuxostat increased the area under the pla …
Plasma peaks of food-derived isoflavone metabolites, daidzein sulfate (DS), and genistein sulfate (GS) increased after lapatin …
Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells.
Issac PK, Karan R, Guru A, Pachaiappan R, Arasu MV, Al-Dhabi NA, Choi KC, Harikrishnan R, Raj JA. Issac PK, et al. Mol Biol Rep. 2021 Aug;48(8):5857-5872. doi: 10.1007/s11033-021-06580-x. Epub 2021 Jul 23. Mol Biol Rep. 2021. PMID: 34302266
Glucose uptake by the L6 myotube cells using 2-NBDG, and with IRTK and PI3K inhibitors (genistein and wortmannin) showed a significant increase in glucose uptake by the cells which shows the up regulated GLUT-4 movement from intracellular pool to the plasma membrane. Morin …
Glucose uptake by the L6 myotube cells using 2-NBDG, and with IRTK and PI3K inhibitors (genistein and wortmannin) showed a significan …
64 results