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Year Number of Results
2013 9
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2,236 results

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Filters applied: in the last 5 years, Free full text, English, Humans. Clear all
Page 1
CRISPR-Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing.
Gostimskaya I. Gostimskaya I. Biochemistry (Mosc). 2022 Aug;87(8):777-788. doi: 10.1134/S0006297922080090. Biochemistry (Mosc). 2022. PMID: 36171658 Free PMC article. Review.
The development of a method for genome editing based on CRISPR-Cas9 technology was awarded The Nobel Prize in Chemistry in 2020, less than a decade after the discovery of all principal molecular components of the system. ...The original biological func …
The development of a method for genome editing based on CRISPR-Cas9 technology was awarded The Nobel Prize in Ch …
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer.
Wang SW, Gao C, Zheng YM, Yi L, Lu JC, Huang XY, Cai JB, Zhang PF, Cui YH, Ke AW. Wang SW, et al. Mol Cancer. 2022 Feb 21;21(1):57. doi: 10.1186/s12943-022-01518-8. Mol Cancer. 2022. PMID: 35189910 Free PMC article. Review.
This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated nuclease 9 (CRISPR/Cas9) genome editing system. ...Here, we review current status of CRISPR/Cas9 gene editing te …
This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated nuclease 9 (CRISPR/ …
Genome Editing Using CRISPR-Cas9 and Autoimmune Diseases: A Comprehensive Review.
Lee MH, Shin JI, Yang JW, Lee KH, Cha DH, Hong JB, Park Y, Choi E, Tizaoui K, Koyanagi A, Jacob L, Park S, Kim JH, Smith L. Lee MH, et al. Int J Mol Sci. 2022 Jan 25;23(3):1337. doi: 10.3390/ijms23031337. Int J Mol Sci. 2022. PMID: 35163260 Free PMC article. Review.
However, few studies on the treatment of autoimmune disease using CRISPR-Cas9 have been reported so far. In this review, we highlight the current and potential use of CRISPR-Cas9 in the management of autoimmune diseases. ...This article will give a new …
However, few studies on the treatment of autoimmune disease using CRISPR-Cas9 have been reported so far. In this review, we hi …
CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer.
Almeida RS, Wisnieski F, Takao Real Karia B, Smith MAC. Almeida RS, et al. Genes (Basel). 2022 Nov 4;13(11):2029. doi: 10.3390/genes13112029. Genes (Basel). 2022. PMID: 36360266 Free PMC article. Review.
Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing …
Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are ext …
CRISPR/Cas9-Mediated Genome Editing in Cancer Therapy.
Ding S, Liu J, Han X, Tang M. Ding S, et al. Int J Mol Sci. 2023 Nov 15;24(22):16325. doi: 10.3390/ijms242216325. Int J Mol Sci. 2023. PMID: 38003514 Free PMC article. Review.
The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria and archaea, has catalyzed the development and application of a new generation of gene edi …
The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system, an RNA-based a …
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing.
Xue C, Greene EC. Xue C, et al. Trends Genet. 2021 Jul;37(7):639-656. doi: 10.1016/j.tig.2021.02.008. Epub 2021 Apr 22. Trends Genet. 2021. PMID: 33896583 Free PMC article. Review.
Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas nucleases to induce DNA double-strand breaks (DSBs) at desired locations within a genome. Furthe …
Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-based genome editing …
CRISPR/Cas9 Genome Editing for Tissue-Specific In Vivo Targeting: Nanomaterials and Translational Perspective.
Sahel DK, Vora LK, Saraswat A, Sharma S, Monpara J, D'Souza AA, Mishra D, Tryphena KP, Kawakita S, Khan S, Azhar M, Khatri DK, Patel K, Singh Thakur RR. Sahel DK, et al. Adv Sci (Weinh). 2023 Jul;10(19):e2207512. doi: 10.1002/advs.202207512. Epub 2023 May 11. Adv Sci (Weinh). 2023. PMID: 37166046 Free PMC article. Review.
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated endonuclease protein, i.e., Cas9, have been discovered as an immune system in bacteria and archaea; nevertheless, they are now being adopted as mainstream biotechnological/molecular scissors tha …
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated endonuclease protein, i.e., Cas9, have been discovered …
Advancing CRISPR genome editing into gene therapy clinical trials: progress and future prospects.
Cetin B, Erendor F, Eksi YE, Sanlioglu AD, Sanlioglu S. Cetin B, et al. Expert Rev Mol Med. 2025 Mar 31;27:e16. doi: 10.1017/erm.2025.10. Expert Rev Mol Med. 2025. PMID: 40160040 Free PMC article. Review.
Genome editing has recently evolved from a theoretical concept to a powerful and versatile set of tools. ...The path finally led the way to the recent FDA approval of the first gene therapy drug utilising the CRISPR/Cas9 system to edit autologou …
Genome editing has recently evolved from a theoretical concept to a powerful and versatile set of tools. ...The path finally l …
The Ethics of Human Embryo Editing via CRISPR-Cas9 Technology: A Systematic Review of Ethical Arguments, Reasons, and Concerns.
Wiley L, Cheek M, LaFar E, Ma X, Sekowski J, Tanguturi N, Iltis A. Wiley L, et al. HEC Forum. 2025 Jun;37(2):267-303. doi: 10.1007/s10730-024-09538-1. Epub 2024 Sep 20. HEC Forum. 2025. PMID: 39302534 Free PMC article.
The possibility of editing the genomes of human embryos has generated significant discussion and interest as a matter of science and ethics. While it holds significant promise to prevent or treat disease, research on and potential clinical applications of human embryo e …
The possibility of editing the genomes of human embryos has generated significant discussion and interest as a matter of science and …
Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9.
Eggers AR, Chen K, Soczek KM, Tuck OT, Doherty EE, Xu B, Trinidad MI, Thornton BW, Yoon PH, Doudna JA. Eggers AR, et al. Cell. 2024 Jun 20;187(13):3249-3261.e14. doi: 10.1016/j.cell.2024.04.031. Epub 2024 May 22. Cell. 2024. PMID: 38781968 Free PMC article.
Thermostable clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas9) enzymes could improve genome-editing efficiency and delivery due to extended protein lifetimes. However, initial experimentation demonstrated Geobacillus ste …
Thermostable clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas9) enzymes could improve genome …
2,236 results