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The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis.
George AJ, Dong B, Lail H, Gomez M, Hoffiz YC, Ware CB, Fang N, Murphy AZ, Hrabovszky E, Wanders D, Mabb AM. George AJ, et al. iScience. 2022 May 10;25(6):104386. doi: 10.1016/j.isci.2022.104386. eCollection 2022 Jun 17. iScience. 2022. PMID: 35620441 Free PMC article.
We knocked out Rnf216/Triad3 in a gonadotropin-releasing hormone (GnRH) hypothalamic cell line. Rnf216/Triad3 knockout (KO) cells had decreased steady-state GnRH and calcium transients. Rnf216/Triad3 KO adult mice had reductions in GnRH neuron soma size and GnRH production …
We knocked out Rnf216/Triad3 in a gonadotropin-releasing hormone (GnRH) hypothalamic cell line. Rnf216/Triad3 knockout (KO) cells had decrea …
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM, Corrêa SAL. Wall MJ, et al. Among authors: george aj. Neuron. 2018 Jun 27;98(6):1124-1132.e7. doi: 10.1016/j.neuron.2018.05.012. Epub 2018 May 31. Neuron. 2018. PMID: 29861284 Free PMC article.