Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1.
Kondo T, Hisatome I, Yoshimura S, Mahati E, Notsu T, Li P, Iitsuka K, Kato M, Ogura K, Miake J, Aiba T, Shimizu W, Kurata Y, Sakata S, Nakasone N, Ninomiya H, Nakai A, Higaki K, Kawata Y, Shirayoshi Y, Yoshida A, Yamamoto K.
Kondo T, et al.
J Arrhythm. 2016 Oct;32(5):433-440. doi: 10.1016/j.joa.2015.10.005. Epub 2015 Nov 25.
J Arrhythm. 2016.
PMID: 27761169
Free PMC article.
BACKGROUND: The human ether-a-go-go-related gene (HERG) encodes the alpha-subunit of rapidly activating delayed-rectifier potassium channels. ...Maturation of the A78T-HERG protein was facilitated by HS, expression of HSF-1, or exposure to geranyl geranyl ace …
BACKGROUND: The human ether-a-go-go-related gene (HERG) encodes the alpha-subunit of rapidly activating delayed-rectifier potassium c …