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Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways.
Ma WH, Li M, Ma HF, Li W, Liu L, Yin Y, Zhou XM, Hou G. Ma WH, et al. Life Sci. 2020 Jan 15;241:117139. doi: 10.1016/j.lfs.2019.117139. Epub 2019 Dec 4. Life Sci. 2020. PMID: 31809714
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis, and with oxidative stress and inflammation as the key pathogenesis. Glycyl-L-histidyl-l-lysine (GHK) is a …
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic …
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.
Pickart L, Margolina A. Pickart L, et al. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. Int J Mol Sci. 2018. PMID: 29986520 Free PMC article. Review.
The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. ...Recent genetic data may explain such diverse protective and healing actions of one mo …
The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to o …
Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.
Bossak-Ahmad K, Wiśniewska MD, Bal W, Drew SC, Frączyk T. Bossak-Ahmad K, et al. Int J Mol Sci. 2020 Aug 27;21(17):6190. doi: 10.3390/ijms21176190. Int J Mol Sci. 2020. PMID: 32867146 Free PMC article.
The tripeptide NH(2)-Gly-His-Lys-COOH (GHK), cis-urocanic acid (cis-UCA) and Cu(II) ions are physiological constituents of the human body and they co-occur (e.g., in the skin and the plasma). While GHK is known as Cu(II)-binding molecule, we found that …
The tripeptide NH(2)-Gly-His-Lys-COOH (GHK), cis-urocanic acid (cis-UCA) and Cu(II) ions are physiological constituents of the …
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Biomed Res Int. 2015;2015:648108. doi: 10.1155/2015/648108. Epub 2015 Jul 7. Biomed Res Int. 2015. PMID: 26236730 Free PMC article. Review.
GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. ...
GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is prop …
Enhanced biological properties of collagen/chitosan-coated poly(epsilon-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass.
Molavi AM, Sadeghi-Avalshahr A, Nokhasteh S, Naderi-Meshkin H. Molavi AM, et al. Prog Biomater. 2020 Jun;9(1-2):25-34. doi: 10.1007/s40204-020-00129-0. Epub 2020 Apr 4. Prog Biomater. 2020. PMID: 32248401 Free PMC article.
Similarly, GHK-Cu-coated scaffolds were prepared by pipetting adequate amount of 1-mM solution of peptide (in milli-Q) on the surface of scaffolds. ...Poly(epsilon-caprolactone)/collagen/chitosan-uncoated scaffold and scaffolds coated with GHK-Cu and b …
Similarly, GHK-Cu-coated scaffolds were prepared by pipetting adequate amount of 1-mM solution of peptide (in milli-Q) on the …
GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.
Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B. Wang X, et al. Wound Repair Regen. 2017 Apr;25(2):270-278. doi: 10.1111/wrr.12520. Epub 2017 Apr 27. Wound Repair Regen. 2017. PMID: 28370978
Glycyl-l-histidyl-l-lysine (GHK)-Cu is considered to be an activator of tissue remodeling, and has been used in cosmetic products. ...In a mice scald model, angiogenesis in burned skin treated with GHK-Cu-liposomes was better compa …
Glycyl-l-histidyl-l-lysine (GHK)-Cu is considered to be an activator of tissue remodeling, and has been u …
Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity.
Ning C, Jiajia J, Meng L, Hongfei Q, Xianglong W, Tingli L. Ning C, et al. Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109746. doi: 10.1016/j.msec.2019.109746. Epub 2019 Jul 5. Mater Sci Eng C Mater Biol Appl. 2019. PMID: 31500015
In this study, we prepared mesoporous silica nanoparticles (MSN) and MSN-COOH with uniform sphere size (~100 nm) and developed multifunctional chitosan coatings loaded with MSN@GHK-Cu (glycyl-L-histidyl-l-lysine-Cu(2+)) as a suitable stra …
In this study, we prepared mesoporous silica nanoparticles (MSN) and MSN-COOH with uniform sphere size (~100 nm) and developed multifunction …
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. Oxid Med Cell Longev. 2012. PMID: 22666519 Free PMC article. Review.
The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. The human tripeptide GHK was discovered in 1973 as an activity in human albumin that caused old human liver tissue to synthesize proteins lik …
The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. The huma …
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
Park JR, Lee H, Kim SI, Yang SR. Park JR, et al. Oncotarget. 2016 Sep 6;7(36):58405-58417. doi: 10.18632/oncotarget.11168. Oncotarget. 2016. PMID: 27517151 Free PMC article.
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. ...Therefore, we examined the effects of GHK-Cu in lipopolysaccharide (LPS)-induced RAW 264.7 macr …
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound hea …
X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties.
Hureau C, Eury H, Guillot R, Bijani C, Sayen S, Solari PL, Guillon E, Faller P, Dorlet P. Hureau C, et al. Chemistry. 2011 Aug 29;17(36):10151-60. doi: 10.1002/chem.201100751. Epub 2011 Jul 20. Chemistry. 2011. PMID: 21780203
We probe that fourth position and study ternary complexes of [Cu(II)(GHK)] with glycine or histidine. The Cu(II) exchange reaction between different DAHK peptides is very slow, in contrast to [Cu(II)(GHK)], in which the fast exchange was attribu …
We probe that fourth position and study ternary complexes of [Cu(II)(GHK)] with glycine or histidine. The Cu(II) exchan …
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