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155 results

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Page 1
The potential of GHK as an anti-aging peptide.
Dou Y, Lee A, Zhu L, Morton J, Ladiges W. Dou Y, et al. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61. doi: 10.31491/apt.2020.03.014. Aging Pathobiol Ther. 2020. PMID: 35083444 Free PMC article.
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound healing and regen …
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have …
Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.
Dymek M, Olechowska K, Hąc-Wydro K, Sikora E. Dymek M, et al. Pharmaceutics. 2023 Oct 18;15(10):2485. doi: 10.3390/pharmaceutics15102485. Pharmaceutics. 2023. PMID: 37896245 Free PMC article.
They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide, GHK-Cu (glycyl-L-histidyl-L-lysine). Anionic (AL) and cationic (CL) hydrogenated lecithin-based liposomes were obtained as …
They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide …
Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.
Jiang F, Wu Y, Liu Z, Hong M, Huang Y. Jiang F, et al. J Cosmet Dermatol. 2023 Sep;22(9):2598-2604. doi: 10.1111/jocd.15763. Epub 2023 Apr 16. J Cosmet Dermatol. 2023. PMID: 37062921
INTRODUCTION: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synthesis. ...CONCLUSION: The co-effect of GHK-Cu and HA was revealed. Their synergy brings an insight to anti-aging technology: ch …
INTRODUCTION: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synth …
Glycyl-l-histidyl-l-lysine-Cu2+ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.
Deng M, Zhang Q, Yan L, Bian Y, Li R, Gao J, Wang Y, Miao J, Li J, Zhou X, Hou G. Deng M, et al. J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1365-1380. doi: 10.1002/jcsm.13213. Epub 2023 Mar 10. J Cachexia Sarcopenia Muscle. 2023. PMID: 36905132 Free PMC article.
Mechanistically, GHK-Cu directly binds and activates SIRT1(the binding energy was -6.1 kcal/mol). Through activating SIRT1 deacetylation, GHK-Cu inhibits FoxO3a transcriptional activity to reduce protein degradation, deacetylates Nrf2 and contribute to …
Mechanistically, GHK-Cu directly binds and activates SIRT1(the binding energy was -6.1 kcal/mol). Through activating SIRT1 dea …
Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.
Bossak-Ahmad K, Wiśniewska MD, Bal W, Drew SC, Frączyk T. Bossak-Ahmad K, et al. Int J Mol Sci. 2020 Aug 27;21(17):6190. doi: 10.3390/ijms21176190. Int J Mol Sci. 2020. PMID: 32867146 Free PMC article.
Regarding the natural concentrations of the studied molecules in some human tissues, together with the affinities reported here, we conclude that the ternary complex [GHK][Cu(II)][cis-urocanic acid] may be partly responsible for biological effects of GHK and urocani …
Regarding the natural concentrations of the studied molecules in some human tissues, together with the affinities reported here, we conclude …
GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.
Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B. Wang X, et al. Wound Repair Regen. 2017 Apr;25(2):270-278. doi: 10.1111/wrr.12520. Epub 2017 Apr 27. Wound Repair Regen. 2017. PMID: 28370978
The nanoscaled GHK-Cu-liposomes promoted HUVECs proliferation, with a 33.1% increased rate. Flow cytometry analysis showed increased cell number at G1 stage and decreased cell number at G2 stage after GHK-Cu-liposomes treatment. ...In a mice scald mode …
The nanoscaled GHK-Cu-liposomes promoted HUVECs proliferation, with a 33.1% increased rate. Flow cytometry analysis showed inc …
Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways.
Ma WH, Li M, Ma HF, Li W, Liu L, Yin Y, Zhou XM, Hou G. Ma WH, et al. Life Sci. 2020 Jan 15;241:117139. doi: 10.1016/j.lfs.2019.117139. Epub 2019 Dec 4. Life Sci. 2020. PMID: 31809714
Glycyl-L-histidyl-l-lysine (GHK) is a tripeptide participating into wound healing and regeneration. GHK-Cu complexes improve GHK bioavailability. Thus, the current study aimed to explore the therapeutic role of GHK-Cu on bleomycin (BLM)-induced pulmona …
Glycyl-L-histidyl-l-lysine (GHK) is a tripeptide participating into wound healing and regeneration. GHK-Cu complexes improve G …
Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?
Ogórek K, Nowak K, Wadych E, Ruzik L, Timerbaev AR, Matczuk M. Ogórek K, et al. Molecules. 2025 Jan 1;30(1):136. doi: 10.3390/molecules30010136. Molecules. 2025. PMID: 39795193 Free PMC article. Review.
Methods for studying the transport of CACs encapsulated by liposomes and free GHK-Cu across the skin barrier are summarized. An analysis of the literature data reveals that the transport of liposomes containing GHK-Cu received little attention. This re …
Methods for studying the transport of CACs encapsulated by liposomes and free GHK-Cu across the skin barrier are summarized. A …
155 results