Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1992 1
1993 1
1995 2
1996 2
1999 1
2003 1
2005 1
2006 3
2007 1
2008 2
2009 1
2010 1
2012 3
2014 4
2015 3
2016 2
2017 1
2018 1
2019 1
2020 5
2021 2
2023 4
2024 4
2025 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

45 results

Results by year

Filters applied: . Clear all
Page 1
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.
Pickart L, Margolina A. Pickart L, et al. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. Int J Mol Sci. 2018. PMID: 29986520 Free PMC article. Review.
GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammat …
GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and sto …
Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?
Ogórek K, Nowak K, Wadych E, Ruzik L, Timerbaev AR, Matczuk M. Ogórek K, et al. Molecules. 2025 Jan 1;30(1):136. doi: 10.3390/molecules30010136. Molecules. 2025. PMID: 39795193 Free PMC article. Review.
GHK-Cu is a fairly hydrophilic compound with limited permeation through the lipophilic stratum corneum. ...Methods for studying the transport of CACs encapsulated by liposomes and free GHK-Cu across the skin barrier are summarized. An analysis o …
GHK-Cu is a fairly hydrophilic compound with limited permeation through the lipophilic stratum corneum. ...Methods for studyin …
The potential of GHK as an anti-aging peptide.
Dou Y, Lee A, Zhu L, Morton J, Ladiges W. Dou Y, et al. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61. doi: 10.31491/apt.2020.03.014. Aging Pathobiol Ther. 2020. PMID: 35083444 Free PMC article.
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound healing an …
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have …
Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.
Jiang F, Wu Y, Liu Z, Hong M, Huang Y. Jiang F, et al. J Cosmet Dermatol. 2023 Sep;22(9):2598-2604. doi: 10.1111/jocd.15763. Epub 2023 Apr 16. J Cosmet Dermatol. 2023. PMID: 37062921
INTRODUCTION: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synthesis. ...At the ratio of 1:9, GHK-Cu and LMW HA deliver the strongest effect to elevate collagen IV synthesis by 25.4 t …
INTRODUCTION: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collage …
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Biomed Res Int. 2015;2015:648108. doi: 10.1155/2015/648108. Epub 2015 Jul 7. Biomed Res Int. 2015. PMID: 26236730 Free PMC article. Review.
In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage, and hyperpigmentation, and increase keratinocyte proliferation. ...The present review revisits GHK's …
In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine …
GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.
Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B. Wang X, et al. Wound Repair Regen. 2017 Apr;25(2):270-278. doi: 10.1111/wrr.12520. Epub 2017 Apr 27. Wound Repair Regen. 2017. PMID: 28370978
In a mice scald model, angiogenesis in burned skin treated with GHK-Cu-liposomes was better compared with free GHK-Cu, and immunofluorescence analysis showed enhanced signal of CD31 and Ki67 in GHK-Cu-liposomes treated mice. Moreov …
In a mice scald model, angiogenesis in burned skin treated with GHK-Cu-liposomes was better compared with free GHK …
Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.
Dymek M, Olechowska K, Hąc-Wydro K, Sikora E. Dymek M, et al. Pharmaceutics. 2023 Oct 18;15(10):2485. doi: 10.3390/pharmaceutics15102485. Pharmaceutics. 2023. PMID: 37896245 Free PMC article.
They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide, GHK-Cu (glycyl-L-histidyl-L-lysine). Anionic (AL) and cationic (CL) hydrogenated lecithin-based liposomes were obtained as …
They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide …
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. Oxid Med Cell Longev. 2012. PMID: 22666519 Free PMC article. Review.
The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. The human tripeptide GHK was discovered in 1973 as an activity in human albumin that caused old human liver tissue to synthesize proteins lik …
The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. T …
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.
Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR. Mortazavi SM, et al. Bioimpacts. 2024 Apr 28;15:30071. doi: 10.34172/bi.30071. eCollection 2025. Bioimpacts. 2024. PMID: 39963574 Free PMC article. Review.
INTRODUCTION: Peptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine peptide (GHK) is one of the most broadly promoted peptide for topical application. ...Although GHK-Cu and Pal-GHK are widel …
INTRODUCTION: Peptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine …
Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.
Bossak-Ahmad K, Wiśniewska MD, Bal W, Drew SC, Frączyk T. Bossak-Ahmad K, et al. Int J Mol Sci. 2020 Aug 27;21(17):6190. doi: 10.3390/ijms21176190. Int J Mol Sci. 2020. PMID: 32867146 Free PMC article.
The tripeptide NH(2)-Gly-His-Lys-COOH (GHK), cis-urocanic acid (cis-UCA) and Cu(II) ions are physiological constituents of the human body and they co-occur (e.g., in the skin and the plasma). While GHK is known as Cu(II)-binding molecule, we found that urocanic acid also c …
The tripeptide NH(2)-Gly-His-Lys-COOH (GHK), cis-urocanic acid (cis-UCA) and Cu(II) ions are physiological constituents of the human body an …
45 results