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82 results

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Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway.
Han R, Zhou D, Ji N, Yin Z, Wang J, Zhang Q, Zhang H, Liu J, Liu X, Liu H, Han Q, Su J. Han R, et al. J Nanobiotechnology. 2025 Jan 23;23(1):41. doi: 10.1186/s12951-025-03096-5. J Nanobiotechnology. 2025. PMID: 39849554 Free PMC article.
Rheumatoid arthritis (RA), a form of autoimmune inflammation, is marked by enduring synovial inflammation and the subsequent impairment of joint function. ...In our research, we delve into the capacity of PEVs to treat RA, highlighting the role of ginger …
Rheumatoid arthritis (RA), a form of autoimmune inflammation, is marked by enduring synovial inflammation and the subse …
Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions.
Yao TK, Lee RP, Wu WT, Chen IH, Yu TC, Yeh KT. Yao TK, et al. Int J Mol Sci. 2024 Oct 9;25(19):10853. doi: 10.3390/ijms251910853. Int J Mol Sci. 2024. PMID: 39409183 Free PMC article. Review.
Gouty arthritis, a prevalent inflammatory condition characterized by the deposition of monosodium urate crystals within joints, often results in debilitating pain and inflammation. ...This review presents a comprehensive overview of both established and emerging the …
Gouty arthritis, a prevalent inflammatory condition characterized by the deposition of monosodium urate crystals within joints, often …
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials.
Long Z, Xiang W, He Q, Xiao W, Wei H, Li H, Guo H, Chen Y, Yuan M, Yuan X, Zeng L, Yang K, Deng Y, Huang Z. Long Z, et al. Front Immunol. 2023 Mar 22;14:1024120. doi: 10.3389/fimmu.2023.1024120. eCollection 2023. Front Immunol. 2023. PMID: 37033930 Free PMC article.
RESULTS: A total of 49 records (47 RCTs) were finally included, involving 3852 participants and 15 types of dietary polyphenols (Cinnamon extract, Cranberry extract, Crocus sativus L. extract, Curcumin, Garlic extract, Ginger extract, Hesperidin, Olive oil, P …
RESULTS: A total of 49 records (47 RCTs) were finally included, involving 3852 participants and 15 types of dietary polyphenols (Cinnamon ex …
Nutrition and diet in rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis: a systematic review.
Van den Bruel K, Kulyk M, Neerinckx B, De Vlam K. Van den Bruel K, et al. Front Med (Lausanne). 2025 Sep 15;12:1655165. doi: 10.3389/fmed.2025.1655165. eCollection 2025. Front Med (Lausanne). 2025. PMID: 41030267 Free PMC article.
INTRODUCTION: This systematic review aimed to evaluate the effects of specific diets, dietary supplements, and probiotics on disease activity, inflammation, and immune response in patients with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), and psoriati …
INTRODUCTION: This systematic review aimed to evaluate the effects of specific diets, dietary supplements, and probiotics on disease activit …
Cedrol from Ginger Ameliorates Rheumatoid Arthritis via Reducing Inflammation and Selectively Inhibiting JAK3 Phosphorylation.
Zhang YM, Shen J, Zhao JM, Guan J, Wei XR, Miao DY, Li W, Xie YC, Zhao YQ. Zhang YM, et al. J Agric Food Chem. 2021 May 12;69(18):5332-5343. doi: 10.1021/acs.jafc.1c00284. Epub 2021 Apr 28. J Agric Food Chem. 2021. PMID: 33908779
Ginger, as a food spice, is widely applied due to its extensive effects. Cedrol (CE) found in ginger is a sesquiterpene with anti-inflammatory activity. The objective of this research is to discuss the efficacy of CE on ameliorating rheumatoid arthritis (RA). …
Ginger, as a food spice, is widely applied due to its extensive effects. Cedrol (CE) found in ginger is a sesquiterpene with a …
Oral ginger-derived extracellular vesicles ameliorate arthritis via anti-inflammatory actions of microRNA-149 and 6-gingerol.
Kaneta H, Nakasa T, Yimiti D, Moriwaki D, Kawasaki R, Ogura T, Miyaki S, Adachi N. Kaneta H, et al. Mol Ther Nucleic Acids. 2026 Jan 19;37(1):102840. doi: 10.1016/j.omtn.2026.102840. eCollection 2026 Mar 12. Mol Ther Nucleic Acids. 2026. PMID: 41674725 Free PMC article.
This study evaluated the therapeutic potential of GDEVs in rheumatoid arthritis (RA), a chronic autoimmune disease characterized by synovial inflammation and joint destruction. ...In vivo, oral administration of GDEVs to CAIA mice reduced arthritis severity, …
This study evaluated the therapeutic potential of GDEVs in rheumatoid arthritis (RA), a chronic autoimmune disease characterized by s …
Cedrol from ginger alleviates rheumatoid arthritis through dynamic regulation of intestinal microenvironment.
Zhang Y, Liu Y, Peng F, Wei X, Hao H, Li W, Zhao Y. Zhang Y, et al. Food Funct. 2022 Nov 14;13(22):11825-11839. doi: 10.1039/d2fo01983c. Food Funct. 2022. PMID: 36314362
The imbalance of intestinal flora would induce immune inflammation. Cedrol (CE), found from ginger by our group earlier, has been proven to play an excellent role in ameliorating rheumatoid arthritis (RA) via acting on JAK3, MAPK, and NF-kappaB. However, ther …
The imbalance of intestinal flora would induce immune inflammation. Cedrol (CE), found from ginger by our group earlier, has b …
The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
Aryaeian N, Shahram F, Mahmoudi M, Tavakoli H, Yousefi B, Arablou T, Jafari Karegar S. Aryaeian N, et al. Gene. 2019 May 25;698:179-185. doi: 10.1016/j.gene.2019.01.048. Epub 2019 Mar 4. Gene. 2019. PMID: 30844477 Clinical Trial.
OBJECTIVE: Rheumatoid Arthritis (RA) is an autoimmune disease. The aim of this study was to investigate the effect of ginger supplementation on the expression of some immunity and inflammation intermediate genes in patients who suffer from RA. ...The reductio …
OBJECTIVE: Rheumatoid Arthritis (RA) is an autoimmune disease. The aim of this study was to investigate the effect of ginger s …
Geniposidic acid from ginger-processed Eucommiae Cortex alleviates rheumatoid arthritis by modulating macrophage lactylation induced by exosomes from inflammatory fibroblast-like synoviocytes.
Pan Y, Deng C, Liu X, Wang S, Chen L, Li A, Shu J, Xu K, Ku X, Wang C. Pan Y, et al. J Nutr Biochem. 2026 Apr;150:110213. doi: 10.1016/j.jnutbio.2025.110213. Epub 2025 Nov 30. J Nutr Biochem. 2026. PMID: 41330460
Eucommiae Cortex (EC), a Traditional Chinese health food product, is known for its anti-inflammatory, antioxidant, and hepatoprotective effects, with promising potential in treating rheumatoid arthritis (RA). This study used liquid chromatography-tandem mass spectrometry ( …
Eucommiae Cortex (EC), a Traditional Chinese health food product, is known for its anti-inflammatory, antioxidant, and hepatoprotective effe …
Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites.
Liu X, Pan Y, Deng C, Zhu M, Guo D, Wu J, Feng F, Pan L, Wang C, Xu K. Liu X, et al. Front Pharmacol. 2025 Oct 28;16:1682504. doi: 10.3389/fphar.2025.1682504. eCollection 2025. Front Pharmacol. 2025. PMID: 41230092 Free PMC article.
We evaluated the therapeutic effects of ginger-processed Gastrodia elata Bl. (G-GEB) on rheumatoid arthritis (RA) and focused on paracine E to elucidate its potential regulatory mechanisms. METHODS: An Sprague-Dawley rat model of rheumatoid arthritis was cons …
We evaluated the therapeutic effects of ginger-processed Gastrodia elata Bl. (G-GEB) on rheumatoid arthritis (RA) and focused …
82 results