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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 1
2007 3
2008 6
2009 3
2010 6
2011 11
2012 6
2013 7
2014 15
2015 10
2016 12
2017 11
2018 7
2019 8
2020 11
2021 4
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104 results
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Page 1
Givinostat: an emerging treatment for polycythemia vera.
Chifotides HT, Bose P, Verstovsek S. Chifotides HT, et al. Expert Opin Investig Drugs. 2020 Jun;29(6):525-536. doi: 10.1080/13543784.2020.1761323. Epub 2020 Jul 21. Expert Opin Investig Drugs. 2020. PMID: 32693648 Review.
Givinostat was well tolerated and yielded promising clinico-hematological responses. A phase III study of givinostat versus hydroxyurea in high-risk PV patients is planned. AREAS COVERED: We present an overview of PV, current treatment guidelines, and the putative m
Givinostat was well tolerated and yielded promising clinico-hematological responses. A phase III study of givinostat versus hy
Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation.
Milan M, Pace V, Maiullari F, Chirivì M, Baci D, Maiullari S, Madaro L, Maccari S, Stati T, Marano G, Frati G, Puri PL, De Falco E, Bearzi C, Rizzi R. Milan M, et al. Cell Death Dis. 2018 Jan 25;9(2):108. doi: 10.1038/s41419-017-0174-5. Cell Death Dis. 2018. PMID: 29371598 Free PMC article.
Here, we studied the effect of the histone deacetylase inhibitor Givinostat on a mouse model of acute myocardial infarction. We found that it contributes to decrease endothelial-to-mesenchymal transition and inflammation, reducing cardiac fibrosis and improving heart perfo …
Here, we studied the effect of the histone deacetylase inhibitor Givinostat on a mouse model of acute myocardial infarction. We found …
Givinostat exhibits in vitro synergy with posaconazole against Aspergillus spp.
Sun Y, Gao L, He C, Wu Q, Li M, Zeng T. Sun Y, et al. Med Mycol. 2017 Oct 1;55(7):798-802. doi: 10.1093/mmy/myw131. Med Mycol. 2017. PMID: 27915302
The results revealed favorable synergistic effects between givinostat and posaconazole (83.3%) against Aspergillus isolates. Limited synergism was observed when givinostat was combined with itraconazole or voriconazole. No interaction was observed between givinos
The results revealed favorable synergistic effects between givinostat and posaconazole (83.3%) against Aspergillus isolates. Limited …
The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.
Savino AM, Sarno J, Trentin L, Vieri M, Fazio G, Bardini M, Bugarin C, Fossati G, Davis KL, Gaipa G, Izraeli S, Meyer LH, Nolan GP, Biondi A, Te Kronnie G, Palmi C, Cazzaniga G. Savino AM, et al. Leukemia. 2017 Nov;31(11):2365-2375. doi: 10.1038/leu.2017.93. Epub 2017 Mar 23. Leukemia. 2017. PMID: 28331226
These findings led us to hypothesize that givinostat might also act against CRLF2-rearranged BCP-ALL, which lack effective therapies. ...Importantly, givinostat killed ruxolitinib-resistant cells and potentiated the effect of current chemotherapy. ...
These findings led us to hypothesize that givinostat might also act against CRLF2-rearranged BCP-ALL, which lack effective therapies. …
Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
Wang YG, Xu L, Wang T, Wei J, Meng WY, Wang N, Shi M. Wang YG, et al. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. doi: 10.3748/wjg.v21.i27.8326. World J Gastroenterol. 2015. PMID: 26217084 Free PMC article.
AIM: To explore the effect of the histone deacetylase inhibitor givinostat on proteins related to regulation of hepatic stellate cell proliferation. ...The scratch assay was used to analyze the effect of givinostat on cell migration. Effects of givinostat on …
AIM: To explore the effect of the histone deacetylase inhibitor givinostat on proteins related to regulation of hepatic stellate cell …
Histone deacetylase inhibitor givinostat: the small-molecule with promising activity against therapeutically challenging haematological malignancies.
Ganai SA. Ganai SA. J Chemother. 2016 Aug;28(4):247-54. doi: 10.1080/1120009X.2016.1145375. Epub 2016 Apr 28. J Chemother. 2016. PMID: 27121910 Review.
However, no review article is available describing thoroughly the role of inhibitor givinostat (ITF2357 or [6-(diethylaminomethyl) naphthalen-2-yl] methyl N-[4-(hydroxycarbamoyl) phenyl] carbamate) in haematological malignancies. Thus, the present review explores the intri …
However, no review article is available describing thoroughly the role of inhibitor givinostat (ITF2357 or [6-(diethylaminomethyl) na …
HDAC Inhibitors as Novel Anti-Cancer Therapeutics.
De Souza C, Chatterji BP. De Souza C, et al. Recent Pat Anticancer Drug Discov. 2015;10(2):145-62. doi: 10.2174/1574892810666150317144511. Recent Pat Anticancer Drug Discov. 2015. PMID: 25782916 Review.
Recently, a spate of drugs acting via HDAC inhibition have been undergoing clinical trials and several patents present exciting molecules like PCI-24781 (Abexinostat), ITF- 2357 (Givinostat); MS-275 (Entinostat), MGCD 0103 (Mocetinostat), LBH-589 (Panobinostat), FK228 (Rom …
Recently, a spate of drugs acting via HDAC inhibition have been undergoing clinical trials and several patents present exciting molecules li …
Potent induction of apoptosis by givinostat in BCR-ABL1-positive and BCR-ABL1-negative precursor B-cell acute lymphoblastic leukemia cell lines.
Yao C, Zhang G, Walker A, Zhao KY, Li Y, Lyu L, Tang Y, Ru P, Jones D, Zhao W. Yao C, et al. Leuk Res. 2017 Sep;60:129-134. doi: 10.1016/j.leukres.2017.08.003. Epub 2017 Aug 9. Leuk Res. 2017. PMID: 28818808
The key signal protein of the BCR-ABL1, Crk-L1, was significantly reduced by givinostat treatment in NAML1. As in SUP-B15, givinostat induced apoptosis in both cell lines but showed different levels of cleavage of the procaspase proteins Casp-3, Casp-7 and PARP. Lev …
The key signal protein of the BCR-ABL1, Crk-L1, was significantly reduced by givinostat treatment in NAML1. As in SUP-B15, givinos
Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia.
Li Y, Zhao K, Yao C, Kahwash S, Tang Y, Zhang G, Patterson K, Wang QE, Zhao W. Li Y, et al. Genes Cancer. 2016 Sep;7(9-10):292-300. doi: 10.18632/genesandcancer.117. Genes Cancer. 2016. PMID: 28050230 Free PMC article.
Givinostat significantly inhibited cell proliferation of SUP-B15 (IC(50):0.180.03muM) and simultaneously inhibited BCR-ABL signal pathway. ...These inhibitory and proapoptotic effects were not observed in K562 simultaneously treated with Givinostat. Finally our stud
Givinostat significantly inhibited cell proliferation of SUP-B15 (IC(50):0.180.03muM) and simultaneously inhibited BCR-ABL signal pat
Histological effects of givinostat in boys with Duchenne muscular dystrophy.
Bettica P, Petrini S, D'Oria V, D'Amico A, Catteruccia M, Pane M, Sivo S, Magri F, Brajkovic S, Messina S, Vita GL, Gatti B, Moggio M, Puri PL, Rocchetti M, De Nicolao G, Vita G, Comi GP, Bertini E, Mercuri E. Bettica P, et al. Neuromuscul Disord. 2016 Oct;26(10):643-649. doi: 10.1016/j.nmd.2016.07.002. Epub 2016 Jul 11. Neuromuscul Disord. 2016. PMID: 27566866 Free article. Clinical Trial.
This study was conducted to evaluate whether the beneficial histological effects of Givinostat could be extended to DMD boys. Twenty ambulant DMD boys aged 7 to <11 years on stable corticosteroid treatment were enrolled in the study and treated for 12 months with Giv
This study was conducted to evaluate whether the beneficial histological effects of Givinostat could be extended to DMD boys. Twenty …
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