Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS.
Georgita C, Albu F, David V, Medvedovici A.
Georgita C, et al.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):211-8. doi: 10.1016/j.jchromb.2007.04.032. Epub 2007 May 1.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007.
PMID: 17500048
Clinical Trial.
Plasma sample preparation is based on protein precipitation by means of organic solvent addition. 1,3,5-Triazine-2,4,6-triamine (IS1) was used as internal standard for metformin, while gliquidone (IS2) played the same role for glibenclamide. Detection was performed with an …
Plasma sample preparation is based on protein precipitation by means of organic solvent addition. 1,3,5-Triazine-2,4,6-triamine (IS1) was us …