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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1975 1
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1979 1
1980 3
1981 1
1982 1
1984 1
1985 1
1986 3
1987 4
1988 3
1989 3
1990 5
1991 9
1992 7
1993 3
1994 6
1996 5
1997 6
1998 7
1999 4
2000 6
2001 14
2002 9
2003 9
2004 11
2005 10
2006 11
2007 14
2008 14
2009 14
2010 18
2011 14
2012 22
2013 16
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2015 34
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2017 20
2018 15
2019 8
2020 14
2021 15
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2025 15
2026 1

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407 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Clegg DO, et al. N Engl J Med. 2006 Feb 23;354(8):795-808. doi: 10.1056/NEJMoa052771. N Engl J Med. 2006. PMID: 16495392 Free article. Clinical Trial.
BACKGROUND: Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee …
BACKGROUND: Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecox …
Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials.
Zhu X, Sang L, Wu D, Rong J, Jiang L. Zhu X, et al. J Orthop Surg Res. 2018 Jul 6;13(1):170. doi: 10.1186/s13018-018-0871-5. J Orthop Surg Res. 2018. PMID: 29980200 Free PMC article. Review.
OBJECTIVE: To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. METHODS: …
OBJECTIVE: To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/ …
Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis.
Liu B, Yang W, Zhang K. Liu B, et al. Nutr Cancer. 2023;75(3):785-794. doi: 10.1080/01635581.2023.2173258. Epub 2023 Jan 30. Nutr Cancer. 2023. PMID: 36715012
The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention. ...Overall, chondroitin and/or glucosamine intake was associated with a lower risk of colorectal cancer (OR = 0.91, 95% CI, 0.87-0.94) …
The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention. .. …
Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis.
Meng Z, Liu J, Zhou N. Meng Z, et al. Arch Orthop Trauma Surg. 2023 Jan;143(1):409-421. doi: 10.1007/s00402-021-04326-9. Epub 2022 Jan 13. Arch Orthop Trauma Surg. 2023. PMID: 35024906
AIMS: Though glucosamine and chondroitin have become common practices for treating knee osteoarthritis, the clinical value of these two drugs in combination are still questionable. ...CONCLUSION: Our study confirmed that the combination of glucosamine and chondroiti …
AIMS: Though glucosamine and chondroitin have become common practices for treating knee osteoarthritis, the clinical value of these t …
Is glucosamine effective for osteoarthritis?
Harrison-Muñoz S, Rojas-Briones V, Irarrázaval S. Harrison-Muñoz S, et al. Medwave. 2017 Mar 15;17(Suppl1):e6867. doi: 10.5867/medwave.2017.6867. Medwave. 2017. PMID: 28306711 Review. English, Spanish.
Several therapeutic options have been proposed, including glucosamine, but its actual usefulness has not yet been established. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. ...We concluded it is not cle …
Several therapeutic options have been proposed, including glucosamine, but its actual usefulness has not yet been established. To ans …
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis.
Rabade A, Viswanatha GL, Nandakumar K, Kishore A. Rabade A, et al. Inflammopharmacology. 2024 Jun;32(3):1759-1775. doi: 10.1007/s10787-024-01460-9. Epub 2024 Apr 6. Inflammopharmacology. 2024. PMID: 38581640
AIM: This study was aimed to assess the efficacy and safety of two oral Symptomatic Slow Acting Drugs for Osteoarthritis (SYSADOAs)-Glucosamine Sulfate, Chondroitin Sulfate, and their combination regimen in the management of knee osteoarthritis (KOA). ...A detailed literat …
AIM: This study was aimed to assess the efficacy and safety of two oral Symptomatic Slow Acting Drugs for Osteoarthritis (SYSADOAs)-Gluco …
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib.
Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N, Berenbaum F, Blanco FJ, Conaghan PG, Doménech G, Henrotin Y, Pap T, Richette P, Sawitzke A, du Souich P, Pelletier JP; MOVES Investigation Group. Hochberg MC, et al. Ann Rheum Dis. 2016 Jan;75(1):37-44. doi: 10.1136/annrheumdis-2014-206792. Epub 2015 Jan 14. Ann Rheum Dis. 2016. PMID: 25589511 Free PMC article. Clinical Trial.
OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. ...
OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in pati …
Glucosamine therapy for treating osteoarthritis.
Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Towheed TE, et al. Cochrane Database Syst Rev. 2005 Apr 18;2005(2):CD002946. doi: 10.1002/14651858.CD002946.pub2. Cochrane Database Syst Rev. 2005. PMID: 15846645 Free PMC article.
In the 10 RCTs in which the Rotta preparation of glucosamine was compared to placebo, glucosamine was found to be superior for pain (SMD -1.31, 95% CI -1.99, -0.64) and function using the Lequesne index (SMD -0.51, 95% CI -0.96, -0.05). ...WOMAC outcomes of pain, st …
In the 10 RCTs in which the Rotta preparation of glucosamine was compared to placebo, glucosamine was found to be superior for …
Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis.
Zhou S, Zhou P, Yang T, Si J, An W, Jiang Y. Zhou S, et al. J Int Med Res. 2025 Apr;53(4):3000605251334460. doi: 10.1177/03000605251334460. Epub 2025 Apr 29. J Int Med Res. 2025. PMID: 40300556 Free PMC article.
ObjectiveObservational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating the use of Mendelian randomization to clarify the true causal relationship.MethodsThe glucosamine supplementation-related genome-wid …
ObjectiveObservational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating …
Efficiency of Glucosamine in Treating Temporomandibular Joint Osteoarthritis: A Meta-Analytic Umbrella Review.
Sivakumar S, Kumar PP, Prasanna PL, Sivakumar G, Balasamy S, Sundramoorthy AK. Sivakumar S, et al. Curr Rheumatol Rev. 2025;21(2):194-201. doi: 10.2174/0115733971309907240527105306. Curr Rheumatol Rev. 2025. PMID: 38867545
RESULTS: This review with meta-analysis focused on pooled estimate mean differences, revealing non-significant but discernible effects of glucosamine on maximum mouth opening (SMD = 0.288, p = 0.15) and pain reduction (SMD = 0.217, p = 0.476) in TMJ-related disorders. CONC …
RESULTS: This review with meta-analysis focused on pooled estimate mean differences, revealing non-significant but discernible effects of …
407 results