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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1917 2
1921 1
1923 1
1942 1
1945 1
1946 6
1947 2
1948 5
1949 3
1950 1
1952 5
1953 2
1954 1
1955 3
1956 4
1957 3
1958 5
1959 5
1960 12
1961 18
1962 8
1963 17
1964 34
1965 29
1966 47
1967 43
1968 47
1969 65
1970 70
1971 68
1972 59
1973 79
1974 56
1975 94
1976 94
1977 117
1978 101
1979 117
1980 116
1981 134
1982 154
1983 197
1984 240
1985 246
1986 267
1987 234
1988 249
1989 309
1990 281
1991 290
1992 284
1993 293
1994 294
1995 337
1996 337
1997 283
1998 284
1999 298
2000 340
2001 318
2002 358
2003 371
2004 466
2005 510
2006 575
2007 618
2008 613
2009 687
2010 766
2011 822
2012 917
2013 919
2014 1040
2015 1060
2016 1127
2017 1209
2018 1277
2019 1313
2020 1405
2021 1441
2022 1283
2023 1220
2024 1275
2025 219

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25,571 results

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Page 1
Cuproptosis Aggravates Pulpitis by Inhibiting the Pentose Phosphate Pathway.
Zhou L, Mao HQ, Wen YH, Chen Z, Zhang L. Zhou L, et al. J Dent Res. 2025 Feb 14:220345251313797. doi: 10.1177/00220345251313797. Online ahead of print. J Dent Res. 2025. PMID: 39953718
Excessive copper becomes toxic, driving inflammation, and, when copper exceeds a certain threshold, it even leads to a novel programmed cell death termed cuproptosis. ...Mechanistically, we found that copper detoxification is dependent on the PPP. We used a (13)C-glucos
Excessive copper becomes toxic, driving inflammation, and, when copper exceeds a certain threshold, it even leads to a novel programm …
In silico based Diabetic Wound Healer from Nature: An Update.
Lather A, Rathee P, Gautam MK, Sharma K, Hooda T. Lather A, et al. Curr Drug Discov Technol. 2025 Feb 11. doi: 10.2174/0115701638336128250122223221. Online ahead of print. Curr Drug Discov Technol. 2025. PMID: 39950482
Diabetes is a chronic metabolic disease of high levels of glucose in the blood and affecting 536.6 million people in the world between the age group of 20-79 with management spent of 11% of the total worldwide. ...The presently used synthetic drugs have high costs, a to
Diabetes is a chronic metabolic disease of high levels of glucose in the blood and affecting 536.6 million people in the world betwee …
Antidiabetic Potential of Senna siamea: alpha-Glucosidase Inhibition, Postprandial Blood Glucose Reduction, Toxicity Evaluation, and Molecular Docking.
Sangkanu S, Heemman A, Phoopha S, Pitakbut T, Udomuksorn W, Dej-Adisai S. Sangkanu S, et al. Scientifica (Cairo). 2025 Jan 23;2025:6650349. doi: 10.1155/sci5/6650349. eCollection 2025. Scientifica (Cairo). 2025. PMID: 39950148 Free PMC article.
The results showed that all extract concentrations significantly reduced fasting blood glucose compared with the control. In addition, results also agreed with the amount of sucrose in the small intestine of rats. In the acute toxicity study, a single dose of the S. …
The results showed that all extract concentrations significantly reduced fasting blood glucose compared with the control. In addition …
Exploration of Antioxidative, Antidiarrheal, and Antihyperglycemic Properties of Artocarpus chama Leaves Along With In Silico Analysis.
Hossen MS, Refat KMNH, Faruque M, Kundu P, Karmakar UK. Hossen MS, et al. Biomed Res Int. 2025 Jan 28;2025:9930195. doi: 10.1155/bmri/9930195. eCollection 2025. Biomed Res Int. 2025. PMID: 39949374 Free PMC article.
Both n-hexane and ethyl acetate fractions exhibited a good antihyperglycemic effect in the oral glucose tolerance test in the experimental mice. In alpha-glucosidase inhibition, the IC(50) value was 25.043 mg/mL. ...After conducting absorption, distribution, metabolism, ex …
Both n-hexane and ethyl acetate fractions exhibited a good antihyperglycemic effect in the oral glucose tolerance test in the experim …
Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes.
Kang H, Lee UJ, Park BY, Kim M, Yang M. Kang H, et al. Diabetes Metab Syndr. 2025 Feb 7;19(2):103203. doi: 10.1016/j.dsx.2025.103203. Online ahead of print. Diabetes Metab Syndr. 2025. PMID: 39947040
We examined the detoxifying effects of MEW on environmental toxicants, including polycyclic aromatic hydrocarbons (PAHs) and oxidative stress, and its impact on gut microbiome composition (N = 30; 49.26 9.55 yrs). ...Despite limitations in serum Mg measurement to assess Mg …
We examined the detoxifying effects of MEW on environmental toxicants, including polycyclic aromatic hydrocarbons (PAHs) and oxidativ …
Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology.
Hao Y, Qi J, Huang X, Liu C, Liu Y. Hao Y, et al. Front Pharmacol. 2025 Jan 29;16:1509032. doi: 10.3389/fphar.2025.1509032. eCollection 2025. Front Pharmacol. 2025. PMID: 39944619 Free PMC article. Review.
So far, more than 300 metabolites have been extracted and identified from EF, exhibiting various pharmacological effects, such as cardiovascular protection, gastrointestinal protection, neuroprotection, anti-inflammation, analgesia, anti-tumor, glucose and lipid metabolism …
So far, more than 300 metabolites have been extracted and identified from EF, exhibiting various pharmacological effects, such as cardiovasc …
Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-gamma activation.
Kumari VBC, Ramu R, Huligere SS, Patil SM, Nayakvadi S, Bijoor S, Manjappara UV, Ahmed MZ, Wong LS. Kumari VBC, et al. Front Microbiol. 2025 Jan 29;15:1502751. doi: 10.3389/fmicb.2024.1502751. eCollection 2024. Front Microbiol. 2025. PMID: 39943964 Free PMC article.
In vivo, male Wistar rats in hyperlipidemic and streptozotocin-induced hyperglycemic models were treated with LB13243 for 4 weeks, followed by analysis of food intake, body weight, serum glucose, lipids, and histopathology. LB13243 inhibited carbohydrate-hydrolyzing enzyme …
In vivo, male Wistar rats in hyperlipidemic and streptozotocin-induced hyperglycemic models were treated with LB13243 for 4 weeks, followed …
Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review.
Zhang T, Li M, Lu J, Wang J, Zhang M, Panichayupakaranant P, Chen H. Zhang T, et al. Molecules. 2025 Feb 3;30(3):665. doi: 10.3390/molecules30030665. Molecules. 2025. PMID: 39942768 Free PMC article. Review.
This review aims to investigate the potential of quinones as a health intervention for T2DM from the multidimensional perspective of their sources, types, structure-activity relationship, glucose-lowering mechanism, toxicity reduction, and bioavailability enhancemen …
This review aims to investigate the potential of quinones as a health intervention for T2DM from the multidimensional perspective of their s …
Multifaceted stress response in Nile tilapia (Oreochromis niloticus) fingerlings: integrative analysis of salinity, ammonia, and stocking density effects on growth, physiology, and gene expression.
Metwaly S, Nasr H, Ahmed K, Fathi M. Metwaly S, et al. Fish Physiol Biochem. 2025 Feb 13;51(1):48. doi: 10.1007/s10695-025-01462-6. Fish Physiol Biochem. 2025. PMID: 39939481 Free PMC article.
Elevated salinity and ammonia also caused significant increases in the activities of ALT, AST, LDH enzymes, along with higher serum glucose levels, while disrupting serum protein and ion concentrations, indicating considerable metabolic and osmoregulatory disturbances. ...
Elevated salinity and ammonia also caused significant increases in the activities of ALT, AST, LDH enzymes, along with higher serum gluco
Safety, tolerability, pharmacokinetics and pharmacodynamics of GZR4, a novel once-weekly basal insulin, in healthy participants: A randomized trial.
Tang C, Su R, Wan L, Zhu M, Pu J, Hao C, Zhao J, He A, Xie T, Li Y, Chen W, Gan ZR. Tang C, et al. Diabetes Obes Metab. 2025 Feb 11. doi: 10.1111/dom.16250. Online ahead of print. Diabetes Obes Metab. 2025. PMID: 39935080
AIMS: Insulin GZR4 (GZR4), a novel once-weekly basal insulin, has demonstrated a favourable safety and low toxicity profile, as well as notable in vivo glycaemic control effects, in preclinical studies. ...It exhibited a dose-dependent and sustained glucose-lowering …
AIMS: Insulin GZR4 (GZR4), a novel once-weekly basal insulin, has demonstrated a favourable safety and low toxicity profile, as well …
25,571 results
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