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5,694 results

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Page 1
Modulation of UDP-glucuronosyltransferase activity by endogenous compounds.
Ishii Y, Nurrochmad A, Yamada H. Ishii Y, et al. Drug Metab Pharmacokinet. 2010;25(2):134-48. doi: 10.2133/dmpk.25.134. Drug Metab Pharmacokinet. 2010. PMID: 20460819 Free article. Review.
Glucuronidation is one of the major pathways of metabolism of endo- and xenobiotics. UDP-Glucuronosyltransferase (UGT)-catalyzed glucuronidation accounts for up to 35% of phase II reactions. ...However, studies about the role of endogenous compounds as an inhibitor or a …
Glucuronidation is one of the major pathways of metabolism of endo- and xenobiotics. UDP-Glucuronosyltransferase (UGT)-catalyzed gluc …
UDP-glucuronosyltransferase activity in human liver and colon.
Strassburg CP, Nguyen N, Manns MP, Tukey RH. Strassburg CP, et al. Gastroenterology. 1999 Jan;116(1):149-60. doi: 10.1016/s0016-5085(99)70239-8. Gastroenterology. 1999. PMID: 9869613
BACKGROUND & AIMS: The contribution of glucuronidation toward human drug metabolism is carried out by the Super gene family of UDP-glucuronosyltransferases (UGTs). Regulation of the human UGT1A locus is tissue specific, resulting in the unique expression of multiple he …
BACKGROUND & AIMS: The contribution of glucuronidation toward human drug metabolism is carried out by the Super gene family of UDP-gl …
The activity of 1-naphthol-UDP-glucuronosyltransferase in the brain.
Ghersi-Egea JF, Walther B, Decolin D, Minn A, Siest G. Ghersi-Egea JF, et al. Neuropharmacology. 1987 Apr;26(4):367-72. doi: 10.1016/0028-3908(87)90190-0. Neuropharmacology. 1987. PMID: 3108693
Microsomal uridine diphosphate (UDP)-glucuronosyltransferase activity in brain towards 1-naphthol was not significantly induced by pretreatment of animals with 3-methylcholanthrene or phenobarbital. ...The hepatic UDP-glucuronosyltransferase deficiency in Gun …
Microsomal uridine diphosphate (UDP)-glucuronosyltransferase activity in brain towards 1-naphthol was not significantly induce …
Regulation of Mammalian UDP-Glucuronosyltransferases.
Wang H, Cao G, Wang G, Hao H. Wang H, et al. Curr Drug Metab. 2018;19(6):490-501. doi: 10.2174/1389200219666180307122945. Curr Drug Metab. 2018. PMID: 29521218 Review.
BACKGROUND: UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity …
BACKGROUND: UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential …
Human UDP-glucuronosyltransferase 2B7.
Radominska-Pandya A, Little JM, Czernik PJ. Radominska-Pandya A, et al. Curr Drug Metab. 2001 Sep;2(3):283-98. doi: 10.2174/1389200013338379. Curr Drug Metab. 2001. PMID: 11513331
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar …
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze …
Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity.
You BH, Gong EC, Choi YH. You BH, et al. Molecules. 2018 Feb 9;23(2):366. doi: 10.3390/molecules23020366. Molecules. 2018. PMID: 29425147 Free PMC article.
Sauchinone, an active lignan isolated from aerial parts of Saururus chinensis (Saururacease), possesses anti-oxidant, anti-inflammatory, and anti-viral activities. ...In human liver microsomes (HLMs), sauchinone inhibited activities of UGT1A1, 1A3, 1A6, and 2 …
Sauchinone, an active lignan isolated from aerial parts of Saururus chinensis (Saururacease), possesses anti-oxidant, anti-inflammato …
Sex differences in UDP-glucuronosyltransferase 2B17 expression and activity.
Gallagher CJ, Balliet RM, Sun D, Chen G, Lazarus P. Gallagher CJ, et al. Drug Metab Dispos. 2010 Dec;38(12):2204-9. doi: 10.1124/dmd.110.035345. Epub 2010 Sep 1. Drug Metab Dispos. 2010. PMID: 20810538 Free PMC article.
UDP-glucuronosyltransferases (UGTs) are enzymes involved in the metabolism of steroid hormones, carcinogens, cancer chemotherapy agents, and addictive agents from cigarettes. Because the UGT2B family of genes has been linked to hormonal regulation in human cell lines in vi …
UDP-glucuronosyltransferases (UGTs) are enzymes involved in the metabolism of steroid hormones, carcinogens, cancer chemotherapy agen …
Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid.
Miles KK, Kessler FK, Smith PC, Ritter JK. Miles KK, et al. Drug Metab Dispos. 2006 Sep;34(9):1632-9. doi: 10.1124/dmd.106.010140. Epub 2006 Jun 21. Drug Metab Dispos. 2006. PMID: 16790558
Using an optimized intestinal microsome preparation method that stabilized the intestinal MPA UGT activity, the MPA UGT activity of male Sprague-Dawley rat intestinal microsomes was characterized. ...The finding that homozygous Gunn rats lack detectable intestinal M …
Using an optimized intestinal microsome preparation method that stabilized the intestinal MPA UGT activity, the MPA UGT activity …
Structure of UDP-glucuronosyltransferases in membranes.
Radominska-Pandya A, Ouzzine M, Fournel-Gigleux S, Magdalou J. Radominska-Pandya A, et al. Methods Enzymol. 2005;400:116-47. doi: 10.1016/S0076-6879(05)00008-X. Methods Enzymol. 2005. PMID: 16399347 Review.
This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes. The first topic described is the subcellular localization of UGTs with special emphasis on the association of these proteins with the endo …
This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes …
Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein.
Matsui M, Nagai F. Matsui M, et al. Biochem J. 1986 Feb 15;234(1):139-44. doi: 10.1042/bj2340139. Biochem J. 1986. PMID: 3085657 Free PMC article.
Hepatic microsomal UDP-glucuronosyltransferases towards androsterone and testosterone were purified by chromatofocusing and UDP-hexanolamine affinity chromatography in Wistar rats which had genetic deficiency of androsterone UDP-glucuronosyltransferase activity …
Hepatic microsomal UDP-glucuronosyltransferases towards androsterone and testosterone were purified by chromatofocusing and UDP-hexan …
5,694 results