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Elevated posterior insula glutamate in patients with sickle cell disease.
Zhou X, Ichesco E, Pucka AQ, Liu Z, O'Brien AR, Harte SE, Harris RE, Wang Y. Zhou X, et al. J Pain. 2025 Feb;27:104743. doi: 10.1016/j.jpain.2024.104743. Epub 2024 Nov 28. J Pain. 2025. PMID: 39615812 Free PMC article.
Sickle cell disease (SCD) is an inherited hemolytic disorder accompanied by chronic pain and recurrent acute painful episodes known as vaso-occlusive crises (VOCs). Increased Glx (glutamate+glutamine) and lowered GABA concentration have been reported in the insula o …
Sickle cell disease (SCD) is an inherited hemolytic disorder accompanied by chronic pain and recurrent acute painful episodes known as vaso- …
The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and gamma-aminobutyric acid in fibromyalgia and healthy subjects: a multimodal neuroimaging study.
Fanton S, Sandström A, Tour J, Kadetoff D, Schalling M, Jensen KB, Sitnikov R, Ellerbrock I, Kosek E. Fanton S, et al. Pain. 2022 Feb 1;163(2):274-286. doi: 10.1097/j.pain.0000000000002309. Pain. 2022. PMID: 34142769 Free PMC article.
The aim of the present multimodal neuroimaging study was to examine the associations of the TSPO polymorphism with: (1) conditioned pain modulation, (2) expectancy-modulated pain processing assessed during functional magnetic resonance imaging, and (3) the concentration and balan …
The aim of the present multimodal neuroimaging study was to examine the associations of the TSPO polymorphism with: (1) conditioned pain mod …
Effect of Repetitive Transcranial Magnetic Stimulation on the Symptoms and Brain Imaging in Patients with Fibromyalgia Syndrome: A Randomized Controlled Pilot Trial.
Ackermann L, Zeller D, Odorfer T, Homola GA, Kampf T, Pham M, Aster HC, Sommer C. Ackermann L, et al. Pain Ther. 2025 Oct;14(5):1547-1572. doi: 10.1007/s40122-025-00770-2. Epub 2025 Aug 30. Pain Ther. 2025. PMID: 40884738 Free PMC article.
INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown to reduce the symptoms of patients with fibromyalgia syndrome (FMS). We tested whether rTMS of the left DLPFC can reduce the main symptoms in …
INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown to reduc …
Upregulation of cortical GABAA receptor concentration in fibromyalgia.
Pomares FB, Roy S, Funck T, Feier NA, Thiel A, Fitzcharles MA, Schweinhardt P. Pomares FB, et al. Pain. 2020 Jan;161(1):74-82. doi: 10.1097/j.pain.0000000000001707. Pain. 2020. PMID: 31569142 Free PMC article.
An imbalance between excitatory and inhibitory neurotransmission has been linked to fibromyalgia (FM). Magnetic resonance spectroscopy has shown increased levels of glutamate in the insula and posterior cingulate cortex in FM as well as reduced insular levels …
An imbalance between excitatory and inhibitory neurotransmission has been linked to fibromyalgia (FM). Magnetic resonance spectros …
Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA.
Bavato F, Esposito F, Dornbierer DA, Zölch N, Quednow BB, Staempfli P, Landolt HP, Seifritz E, Bosch OG. Bavato F, et al. Cereb Cortex. 2023 Jun 8;33(12):8046-8055. doi: 10.1093/cercor/bhad097. Cereb Cortex. 2023. PMID: 36967111 Free PMC article. Clinical Trial.
Hence, we performed a placebo-controlled, double-blind, randomized, cross-over pharmacological magnetic resonance imaging study with a nocturnal administration of GHB, combined with magnetic resonance spectroscopy of GABA and glutamate in the anterior cingula …
Hence, we performed a placebo-controlled, double-blind, randomized, cross-over pharmacological magnetic resonance imaging study with a noctu …
Excitatory and inhibitory brain metabolites as targets of motor cortex transcranial direct current stimulation therapy and predictors of its efficacy in fibromyalgia.
Foerster BR, Nascimento TD, DeBoer M, Bender MA, Rice IC, Truong DQ, Bikson M, Clauw DJ, Zubieta JK, Harris RE, DaSilva AF. Foerster BR, et al. Arthritis Rheumatol. 2015 Feb;67(2):576-81. doi: 10.1002/art.38945. Arthritis Rheumatol. 2015. PMID: 25371383 Free PMC article. Clinical Trial.
There was a trend toward increased levels of gamma-aminobutyric acid (GABA) in the anterior insula after active tDCS, compared with baseline (P = 0.064). ...CONCLUSION: The present findings suggest that GABA, Glx, and NAA play an important role …
There was a trend toward increased levels of gamma-aminobutyric acid (GABA) in the anterior insula after active …
Cingulate GABA levels inversely correlate with the intensity of ongoing chronic knee osteoarthritis pain.
Reckziegel D, Raschke F, Cottam WJ, Auer DP. Reckziegel D, et al. Mol Pain. 2016 May 20;12:1744806916650690. doi: 10.1177/1744806916650690. Print 2016. Mol Pain. 2016. PMID: 27206661 Free PMC article.
In fibromyalgia, low mid-anterior cingulate cortex gamma-aminobutyric acid was associated with high pain suggesting a role of prefrontal disinhibition. ...The pain gamma-aminobutyric acid interrelation remained strong when controll …
In fibromyalgia, low mid-anterior cingulate cortex gamma-aminobutyric acid was associated with high pain suggest …
Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.
Harris RE, Napadow V, Huggins JP, Pauer L, Kim J, Hampson J, Sundgren PC, Foerster B, Petrou M, Schmidt-Wilcke T, Clauw DJ. Harris RE, et al. Anesthesiology. 2013 Dec;119(6):1453-64. doi: 10.1097/ALN.0000000000000017. Anesthesiology. 2013. PMID: 24343290 Clinical Trial.
METHODS: To identify the clinical action of pregabalin, a proven analgesic, the authors performed three complementary brain neuroimaging procedures: (proton magnetic resonance spectroscopy, functional magnetic resonance imaging, and functional connectivity magnetic resonan …
METHODS: To identify the clinical action of pregabalin, a proven analgesic, the authors performed three complementary brain neuroimaging pro …
Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls.
Ellerbrock I, Sandström A, Tour J, Fanton S, Kadetoff D, Schalling M, Jensen KB, Sitnikov R, Kosek E. Ellerbrock I, et al. Mol Brain. 2021 May 12;14(1):81. doi: 10.1186/s13041-021-00789-4. Mol Brain. 2021. PMID: 33980291 Free PMC article.
Polymorphisms of these genes affect mood and endogenous pain modulation, both demonstrated to be altered in fibromyalgia subjects (FMS). Here, we tested the effects of genetic variants of the 5-HT(1A) receptor (CC/G-carriers) and 5-HTT (high/intermediate/low expression) on …
Polymorphisms of these genes affect mood and endogenous pain modulation, both demonstrated to be altered in fibromyalgia subjects (FM …