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27 results

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Page 1
Impact of D-Amino Acids in Schizophrenia.
Dursun SM, Dursun LH, Baker GB. Dursun SM, et al. Biomolecules. 2025 Sep 2;15(9):1270. doi: 10.3390/biom15091270. Biomolecules. 2025. PMID: 41008577 Free PMC article. Review.
Three of these amino acids, namely D-serine, D-aspartate, and D-alanine, have been proposed to play a role in the etiology of schizophrenia via interactions with glutamate receptors. D-Serine and D-alanine act at the glycine modulatory site on the NMDA receptor, whi …
Three of these amino acids, namely D-serine, D-aspartate, and D-alanine, have been proposed to play a role in the etiology of schizophrenia …
Excitotoxins in foods.
Olney JW. Olney JW. Neurotoxicology. 1994 Fall;15(3):535-44. Neurotoxicology. 1994. PMID: 7854587 Review.
The most frequently encountered food excitotoxin is glutamate (Glu) which is commercially added to many foods despite evidence that it can freely penetrate certain brain regions and rapidly destroy neurons by hyperactivating the NMDA subtype of Glu receptor. ...On t …
The most frequently encountered food excitotoxin is glutamate (Glu) which is commercially added to many foods despite evidence that i …
Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission.
Fukuyama K, Hasegawa T, Okada M. Fukuyama K, et al. Int J Mol Sci. 2018 Nov 19;19(11):3645. doi: 10.3390/ijms19113645. Int J Mol Sci. 2018. PMID: 30463253 Free PMC article.
To explore pathophysiology of schizophrenia, this study analyzed the regulation mechanisms that are associated with cystine/glutamate antiporter (Sxc), group-II (II-mGluR), and group-III (III-mGluR) metabotropic glutamate-receptors in thalamo-cortical glutamatergic …
To explore pathophysiology of schizophrenia, this study analyzed the regulation mechanisms that are associated with cystine/glutamate …
Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice.
Suzuki N, Oota-Ishigaki A, Kaizuka T, Itoh M, Yamazaki M, Natsume R, Abe M, Sakimura K, Mishina M, Hayashi T. Suzuki N, et al. Mol Neurobiol. 2024 Nov;61(11):9125-9135. doi: 10.1007/s12035-024-04166-9. Epub 2024 Apr 9. Mol Neurobiol. 2024. PMID: 38592586 Free PMC article.
Proper regulation of N-methyl-D-aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory synaptic functions in the mammalian brain. ...Posttranslational protein S-palmitoylation, the covalent attachment of palmitic acid to in …
Proper regulation of N-methyl-D-aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory syn …
D-Serine in the aging hippocampus.
Billard JM. Billard JM. J Pharm Biomed Anal. 2015 Dec 10;116:18-24. doi: 10.1016/j.jpba.2015.02.013. Epub 2015 Feb 16. J Pharm Biomed Anal. 2015. PMID: 25740810 Review.
The impaired efficacy of endogenous D-serine is not due to changes in the affinity to glycine-binding site but to a decrease in tissue levels of the amino acid resulting from a weaker expression of the producing enzyme serine racemase (SR). ...Accordingly, senescent rats c …
The impaired efficacy of endogenous D-serine is not due to changes in the affinity to glycine-binding site but to a decrease in tissue level …
Hydrogen Sulfide (H2S)/Polysulfides (H2Sn) Signalling and TRPA1 Channels Modification on Sulfur Metabolism.
Kimura H. Kimura H. Biomolecules. 2024 Jan 19;14(1):129. doi: 10.3390/biom14010129. Biomolecules. 2024. PMID: 38275758 Free PMC article. Review.
H(2)S(n), which have additional sulfur atoms to H(2)S, and other S-sulfurated molecules such as cysteine persulfide and S-sulfurated cysteine residues of proteins, are produced by enzymes including 3-mercaptopyruvate sulfurtransferase (3MST). ...Recently, we found t …
H(2)S(n), which have additional sulfur atoms to H(2)S, and other S-sulfurated molecules such as cysteine persulfide and S-sulfurated …
Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID.
Fesharaki Zadeh A, Arnsten AFT, Wang M. Fesharaki Zadeh A, et al. Neurol Int. 2023 May 31;15(2):725-742. doi: 10.3390/neurolint15020045. Neurol Int. 2023. PMID: 37368329 Free PMC article. Review.
COVID-19 infection greatly increases kynurenic acid (KYNA) and glutamate carboxypeptidase II (GCPII) in brain, both of which can be particularly deleterious to PFC function. KYNA blocks both NMDA and nicotinic-alpha-7 receptors, the two receptors required for …
COVID-19 infection greatly increases kynurenic acid (KYNA) and glutamate carboxypeptidase II (GCPII) in brain, both of which c …
L-cysteine, a bicarbonate-sensitive endogenous excitotoxin.
Olney JW, Zorumski C, Price MT, Labruyere J. Olney JW, et al. Science. 1990 May 4;248(4955):596-9. doi: 10.1126/science.2185543. Science. 1990. PMID: 2185543
This neurotoxicity of L-cysteine, in vitro or in vivo, has now been shown to be mediated primarily through the N-methyl-D-aspartate subtype of glutamate receptor (with quisqualate receptor participation at higher concentrations). In addition, the excitotoxic potency …
This neurotoxicity of L-cysteine, in vitro or in vivo, has now been shown to be mediated primarily through the N-methyl-D-aspartate s …
D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain.
Semenza ER, Harraz MM, Abramson E, Malla AP, Vasavda C, Gadalla MM, Kornberg MD, Snyder SH, Roychaudhuri R. Semenza ER, et al. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2110610118. doi: 10.1073/pnas.2110610118. Proc Natl Acad Sci U S A. 2021. PMID: 34556581 Free PMC article.
However, the d-stereoisomer of the amino acid with the fastest spontaneous racemization ratein vitro in vitro, cysteine, has not been examined in mammals. Using chiral high-performance liquid chromatography and a stereospecific luciferase assay, we identify endogeno …
However, the d-stereoisomer of the amino acid with the fastest spontaneous racemization ratein vitro in vitro, cysteine, has n …
N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.
Wright DJ, Gray LJ, Finkelstein DI, Crouch PJ, Pow D, Pang TY, Li S, Smith ZM, Francis PS, Renoir T, Hannan AJ. Wright DJ, et al. Hum Mol Genet. 2016 Jul 15;25(14):2923-2933. doi: 10.1093/hmg/ddw144. Epub 2016 May 14. Hum Mol Genet. 2016. PMID: 27179791
Glutamatergic dysfunction has been implicated in the pathogenesis of depressive disorders and Huntington's disease (HD), in which depression is the most common psychiatric symptom. Synaptic glutamate homeostasis is regulated by cystine-dependent glutamate tra …
Glutamatergic dysfunction has been implicated in the pathogenesis of depressive disorders and Huntington's disease (HD), in which depression …
27 results