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Did you mean glutamate cysteine ligase gcl (459 results)?
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.
Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM. Kang YP, et al. Cell Metab. 2021 Jan 5;33(1):174-189.e7. doi: 10.1016/j.cmet.2020.12.007. Epub 2020 Dec 22. Cell Metab. 2021. PMID: 33357455 Free PMC article.
Here, we find that cystine starvation of non-small-cell lung cancer cell lines induces an unexpected accumulation of gamma-glutamyl-peptides, which are produced due to a non-canonical activity of glutamate-cysteine ligase catalytic subunit (GCLC). This …
Here, we find that cystine starvation of non-small-cell lung cancer cell lines induces an unexpected accumulation of gamma-glutamyl-peptides …
Glutathione synthesis.
Lu SC. Lu SC. Biochim Biophys Acta. 2013 May;1830(5):3143-53. doi: 10.1016/j.bbagen.2012.09.008. Epub 2012 Sep 17. Biochim Biophys Acta. 2013. PMID: 22995213 Free PMC article. Review.
Key determinants of GSH synthesis are the availability of the sulfur amino acid precursor, cysteine, and the activity of the rate-limiting enzyme, glutamate cysteine ligase (GCL), which is composed of a catalytic (GCLC) and a modifier (GCLM) sub …
Key determinants of GSH synthesis are the availability of the sulfur amino acid precursor, cysteine, and the activity of the rate-lim …
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
Zhao C, Zhang T, Xue ST, Zhang P, Wang F, Li Y, Liu Y, Zhao L, Wu J, Yan Y, Mao X, Chen Y, Yuan J, Li Z, Li K. Zhao C, et al. Cell Metab. 2025 Mar 4;37(3):692-707.e9. doi: 10.1016/j.cmet.2024.09.013. Epub 2024 Oct 22. Cell Metab. 2025. PMID: 39442522 Free article.
Here, we performed TME metabolomic analysis in high-fat diet (HFD) mouse models and found that glutathione (GSH) levels were elevated in the TME of obesity-accelerated breast cancer. The deletion of glutamate-cysteine ligase catalytic subunit (GCLC), t …
Here, we performed TME metabolomic analysis in high-fat diet (HFD) mouse models and found that glutathione (GSH) levels were elevated in the …
Andrographolide attenuates SARS-CoV-2 infection via an up-regulation of glutamate-cysteine ligase catalytic subunit (GCLC).
Chaopreecha J, Phueakphud N, Suksatu A, Krobthong S, Manopwisedjaroen S, Panyain N, Hongeng S, Thitithanyanont A, Wongtrakoongate P. Chaopreecha J, et al. Phytomedicine. 2025 Jan;136:156279. doi: 10.1016/j.phymed.2024.156279. Epub 2024 Nov 30. Phytomedicine. 2025. PMID: 39631298
In addition, transcriptional expression of GCLC and glutamate-cysteine ligase modifier subunit (GCLM), which are NRF2 target genes, were induced by andrographolide. ...Moreover, andrographolide also induced expression of the glutathione producing enzym …
In addition, transcriptional expression of GCLC and glutamate-cysteine ligase modifier subunit (GCLM), which are …
Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma.
Da D, Pan Z, Zeng L, Dang Y, Dang C, Huang Y, Shi D, Li H. Da D, et al. Asian J Surg. 2023 Jan;46(1):143-149. doi: 10.1016/j.asjsur.2022.02.005. Epub 2022 Mar 1. Asian J Surg. 2023. PMID: 35241341 Free article.
OBJECTIVES: To determine the expression and function of glutamate-cysteine ligase catalytic (GCLC) and glutamate-cysteine ligase catalytic modifier (GCLM) in gastric adenocarcinoma. ...Moreover, the method of immunochemistry was us …
OBJECTIVES: To determine the expression and function of glutamate-cysteine ligase catalytic (GCLC) and glutam …
NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.
Niu K, Chen Z, Li M, Ma G, Deng Y, Zhang J, Wei D, Wang J, Zhao Y. Niu K, et al. Redox Biol. 2025 Feb;79:103479. doi: 10.1016/j.redox.2024.103479. Epub 2024 Dec 19. Redox Biol. 2025. PMID: 39742570 Free PMC article.
Here, we demonstrate that NSUN2 activity is enhanced by lactate-mediated lactylation at lysine 508, which then targets glutamate-cysteine ligase catalytic subunit (GCLC) mRNA to facilitates GCLC m(5)C formation and mRNA stabilization. ...Specifi …
Here, we demonstrate that NSUN2 activity is enhanced by lactate-mediated lactylation at lysine 508, which then targets glutamate-c …
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism.
Liu J, Tang H, Chen F, Li C, Xie Y, Kang R, Tang D. Liu J, et al. Sci Rep. 2024 Nov 28;14(1):29579. doi: 10.1038/s41598-024-81317-x. Sci Rep. 2024. PMID: 39609608 Free PMC article.
The classical cuproptosis inducer, ES-Cu (elesclomol plus copper), increases the protein stability of the transcription factor NFE2L2 (also known as NRF2), leading to the upregulation of gene expression of glutamate-cysteine ligase modifier subunit (GCLM) and …
The classical cuproptosis inducer, ES-Cu (elesclomol plus copper), increases the protein stability of the transcription factor NFE2L2 (also …
Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women.
Yang C, Xi M, Liu H, Bai H, Jiang C, Liu Q, Fan P. Yang C, et al. Reprod Sci. 2022 Jun;29(6):1790-1800. doi: 10.1007/s43032-021-00764-3. Epub 2021 Oct 12. Reprod Sci. 2022. PMID: 34642912
Polycystic ovary syndrome (PCOS) is generally considered a multifactorial disease caused by interactions between multiple susceptible genes and environmental factors. Glutamate cysteine ligase (GCL) is the rate-limiting enzyme in glutathione biosynthesis. ... …
Polycystic ovary syndrome (PCOS) is generally considered a multifactorial disease caused by interactions between multiple susceptible genes …
ISG15 Enhances the Activity of gamma-Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet-Promoted Hepatocellular Carcinoma.
Liu X, Ma Q, Jia Z, Zhou Y, Zou C, Xiao Y, Chen Y, Ma C, Song L, Yang J, Wang C, Xu H, Chen H, Shi J, Yue J, Sun Y, Hu D, Petersen RB, Li Y, Peng A, Huang K, Zheng L. Liu X, et al. Adv Sci (Weinh). 2025 May;12(19):e2416401. doi: 10.1002/advs.202416401. Epub 2025 Mar 24. Adv Sci (Weinh). 2025. PMID: 40126377 Free PMC article.
Mechanistically, ISG15 promotes the activity of gamma-glutamate cysteine ligase (gamma-GCL), a rate-limiting heterodimeric holoenzyme of glutathione synthesis consisting of glutamate-cysteine ligase catalytic subunit (GCLC) and …
Mechanistically, ISG15 promotes the activity of gamma-glutamate cysteine ligase (gamma-GCL), a rate-limiting heterodime …
Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes.
Azarova I, Klyosova E, Lazarenko V, Konoplya A, Polonikov A. Azarova I, et al. Mol Biol Rep. 2020 Aug;47(8):5793-5805. doi: 10.1007/s11033-020-05647-5. Epub 2020 Jul 26. Mol Biol Rep. 2020. PMID: 32715377
This study investigated whether single nucleotide polymorphisms (SNPs) at genes encoding glutamate cysteine ligase catalytic (rs12524494, rs17883901, rs606548, rs636933, rs648595, rs761142 at GCLC) and modifier (rs2301022, rs3827715, rs7517826, rs41303 …
This study investigated whether single nucleotide polymorphisms (SNPs) at genes encoding glutamate cysteine ligase cata …
844 results