Astrocyte-Neuron Interaction via the Glutamate-Glutamine Cycle and Its Dysfunction in Tau-Dependent Neurodegeneration.
Int J Mol Sci. 2024.
PMID: 38474295
Free PMC article.
Review.
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Correction to: Reevaluation of Astrocyte‑Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ Pumping Rates.
Neurochem Res. 2022.
PMID: 35044619
No abstract available.
Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ Pumping Rates.
Neurochem Res. 2020.
PMID: 32948935
Review.
Search results
Page 1
The Glutamate/GABA-Glutamine Cycle: Insights, Updates, and Advances.
J Neurochem. 2025 Mar;169(3):e70029. doi: 10.1111/jnc.70029.
J Neurochem. 2025.
PMID: 40066661
Free PMC article.
Review.
Synaptic homeostasis of the principal neurotransmitters glutamate and GABA is tightly regulated by an intricate metabolic coupling between neurons and astrocytes known as the glutamate/GABA-glutamine cycle. ...Astrocytic glutami …
Synaptic homeostasis of the principal neurotransmitters glutamate and GABA is tightly regulated by an intricate metabolic coupling be …
Astrocyte-Neuron Interaction via the Glutamate-Glutamine Cycle and Its Dysfunction in Tau-Dependent Neurodegeneration.
Int J Mol Sci. 2024 Mar 6;25(5):3050. doi: 10.3390/ijms25053050.
Int J Mol Sci. 2024.
PMID: 38474295
Free PMC article.
Review.
In this respect, the transfer of essential amino acids such as glutamate and glutamine between neurons and astrocytes in the glutamate-glutamine cycle (GGC) is one example. In this review, we focus on the GGC and the disruption of …
In this respect, the transfer of essential amino acids such as glutamate and glutamine between neurons and astrocyte …
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle.
Prog Neurobiol. 2022 Oct;217:102331. doi: 10.1016/j.pneurobio.2022.102331. Epub 2022 Jul 21.
Prog Neurobiol. 2022.
PMID: 35872221
Review.
Neurotransmitter recycling is intimately linked to astrocyte energy metabolism. In the course of AD, astrocytes undergo extensive metabolic remodeling, which may profoundly affect the glutamate/GABA-glutamine cycle. ...In addition, several as …
Neurotransmitter recycling is intimately linked to astrocyte energy metabolism. In the course of AD, astrocytes undergo extens …
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
J Neurochem. 2006 Aug;98(3):641-53. doi: 10.1111/j.1471-4159.2006.03913.x. Epub 2006 Jun 19.
J Neurochem. 2006.
PMID: 16787421
Free article.
Review.
A metabolite shuttle known as the glutamate/GABA-glutamine cycle describes the release of neurotransmitter glutamate or GABA from neurons and subsequent uptake into astrocytes. ...Furthermore, a section is devoted to the accompanying ammo …
A metabolite shuttle known as the glutamate/GABA-glutamine cycle describes the release of neurotransmitter glutamate …
Brain Glucose Metabolism: Integration of Energetics with Function.
Physiol Rev. 2019 Jan 1;99(1):949-1045. doi: 10.1152/physrev.00062.2017.
Physiol Rev. 2019.
PMID: 30565508
Free article.
Review.
Exact details of neuron-astrocyte glutamate-glutamine cycling remain to be established, and the specific roles of glucose and lactate in the cellular energetics of these processes are debated. ...Shuttling of glucose- and glycogen-derived lactat …
Exact details of neuron-astrocyte glutamate-glutamine cycling remain to be established, and the specific …
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration.
Neuropharmacology. 2021 Sep 15;196:108719. doi: 10.1016/j.neuropharm.2021.108719. Epub 2021 Jul 15.
Neuropharmacology. 2021.
PMID: 34273389
Free article.
Review.
Glutamate is extensively recycled between neurons and astrocytes in a process known as the glutamate-glutamine cycle. ...However, a considerable amount of glutamate is also metabolized and serves as a metabolic hub connecting gluco …
Glutamate is extensively recycled between neurons and astrocytes in a process known as the glutamate-glutamin …
Introduction to the Glutamate-Glutamine Cycle.
Adv Neurobiol. 2016;13:1-7. doi: 10.1007/978-3-319-45096-4_1.
Adv Neurobiol. 2016.
PMID: 27885624
The term 'glutamate-glutamine cycle' was coined several decades ago based on the observation that using certain (14)C-labeled precursors for studies of brain metabolism the specific radioactivity of glutamine generated from glutamate was higher …
The term 'glutamate-glutamine cycle' was coined several decades ago based on the observation that using certain (14)C-l …
Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na(+)/K(+) Pumping Rates.
Neurochem Res. 2020 Nov;45(11):2607-2630. doi: 10.1007/s11064-020-03125-9. Epub 2020 Sep 18.
Neurochem Res. 2020.
PMID: 32948935
Review.
After adjustment, astrocytic glucose oxidation rates in resting awake rat brain are 4-10 fold higher than neuronal oxidation rates. ...Ion flux calculations to evaluate sodium/potassium homeostasis during neurotransmission are not correct if astrocyte-neur …
After adjustment, astrocytic glucose oxidation rates in resting awake rat brain are 4-10 fold higher than neuronal oxidation r …
Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors.
Int J Biol Sci. 2026 Jan 1;22(2):553-565. doi: 10.7150/ijbs.123740. eCollection 2026.
Int J Biol Sci. 2026.
PMID: 41522363
Free PMC article.
The regulation of the homeostasis of the glutamate (Glu)-glutamine (Gln) cycle within the medial prefrontal cortex (mPFC) has garnered substantial interest due to its essential role in maintaining normal emotional behaviors. ...To achieve this goal, the genes …
The regulation of the homeostasis of the glutamate (Glu)-glutamine (Gln) cycle within the medial prefrontal cortex (mPF …
The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain.
J Neurosci Res. 2007 Nov 15;85(15):3347-58. doi: 10.1002/jnr.21444.
J Neurosci Res. 2007.
PMID: 17847118
Review.
Both astrocytes and neurons distinguish between exogenous glutamate and glutamate formed endogenously from glutamine via glutaminase. ...Both astrocytes and neurons utilize glutamate, albeit for cell-specific metabolic fates …
Both astrocytes and neurons distinguish between exogenous glutamate and glutamate formed endogenously from gl …
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