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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1962 3
1968 1
1969 1
1971 1
1973 2
1974 3
1975 4
1976 2
1977 5
1978 6
1979 14
1980 25
1981 19
1982 19
1983 20
1984 17
1985 21
1986 31
1987 27
1988 36
1989 64
1990 100
1991 82
1992 103
1993 124
1994 143
1995 168
1996 155
1997 169
1998 188
1999 178
2000 189
2001 177
2002 170
2003 195
2004 157
2005 188
2006 175
2007 191
2008 183
2009 203
2010 182
2011 210
2012 231
2013 213
2014 239
2015 234
2016 237
2017 206
2018 193
2019 161
2020 95
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5,285 results
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Page 1
Glutamate receptors, neurotoxicity and neurodegeneration.
Lau A, Tymianski M. Lau A, et al. Pflugers Arch. 2010 Jul;460(2):525-42. doi: 10.1007/s00424-010-0809-1. Epub 2010 Mar 14. Pflugers Arch. 2010. PMID: 20229265 Review.
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the central nervous system (CNS), the implications of glutamate excitotoxicity …
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal dysfunction and degeneration. As g …
Taurine Protects Glutamate Neurotoxicity in Motor Neuron Cells.
Lee NY, Kang YS. Lee NY, et al. Adv Exp Med Biol. 2017;975 Pt 2:887-895. doi: 10.1007/978-94-024-1079-2_70. Adv Exp Med Biol. 2017. PMID: 28849508
D-serine is known to a key factor of determination on glutamate toxicity in ALS. Therefore, in the present study, we investigated neuroprotective effects of taurine from glutamate excitotoxicity using motor neuron cells, mtSOD1 (G93A) transgenic cell line model of A …
D-serine is known to a key factor of determination on glutamate toxicity in ALS. Therefore, in the present study, we investigated neu …
Metabolism of Dietary Glutamate in Adults.
Cynober L. Cynober L. Ann Nutr Metab. 2018;73 Suppl 5:5-14. doi: 10.1159/000494776. Epub 2018 Dec 3. Ann Nutr Metab. 2018. PMID: 30508813 Free article. Review.
BACKGROUND: Glutamate is a non-essential amino acid at the crossroads of nitrogen and energy metabolism. Glutamate metabolism is characterized by reactions that may be anabolic or catabolic in nature depending on the tissue (i.e., glutamate dehydrogena …
BACKGROUND: Glutamate is a non-essential amino acid at the crossroads of nitrogen and energy metabolism. Glutamate meta …
Dysregulation of Glutamate Cycling Mediates Methylmercury-Induced Neurotoxicity.
Culbreth M, Aschner M. Culbreth M, et al. Adv Neurobiol. 2016;13:295-305. doi: 10.1007/978-3-319-45096-4_11. Adv Neurobiol. 2016. PMID: 27885634
To examine the toxicological implications of glutamate, this chapter will focus specifically on its impact in the brain. More explicitly, it will illustrate the role glutamate plays in mediating methylmercury (MeHg)-induced neurotoxicity. ...This process has …
To examine the toxicological implications of glutamate, this chapter will focus specifically on its impact in the brain. More explici …
Ginger and Propolis Exert Neuroprotective Effects against Monosodium Glutamate-Induced Neurotoxicity in Rats.
Hussein UK, Hassan NEY, Elhalwagy MEA, Zaki AR, Abubakr HO, Nagulapalli Venkata KC, Jang KY, Bishayee A. Hussein UK, et al. Molecules. 2017 Nov 8;22(11):1928. doi: 10.3390/molecules22111928. Molecules. 2017. PMID: 29117134 Free PMC article.
The objective of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural products, such as ginger or propolis, in male rats. ...In contrast, treatment with ginger greatly attenuated the neurotoxic effects of MS …
The objective of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural prod …
Mitochondrial dysfunction associated with nitric oxide pathways in glutamate neurotoxicity.
Manucha W. Manucha W. Clin Investig Arterioscler. 2017 Mar-Apr;29(2):92-97. doi: 10.1016/j.arteri.2016.04.002. Epub 2016 May 27. Clin Investig Arterioscler. 2017. PMID: 27240721 Review. English, Spanish.
Multiple mechanisms underlying glutamate-induced neurotoxicity have recently been discussed. Likewise, a clear deregulation of the mitochondrial respiratory mechanism has been described in patients with neurodegeneration, oxidative stress, and inflammation. ...Inter …
Multiple mechanisms underlying glutamate-induced neurotoxicity have recently been discussed. Likewise, a clear deregulation of …
Role of Astrocytes in Manganese Neurotoxicity Revisited.
Ke T, Sidoryk-Wegrzynowicz M, Pajarillo E, Rizor A, Soares FAA, Lee E, Aschner M. Ke T, et al. Neurochem Res. 2019 Nov;44(11):2449-2459. doi: 10.1007/s11064-019-02881-7. Epub 2019 Sep 30. Neurochem Res. 2019. PMID: 31571097 Review.
The clinical symptoms of Mn neurotoxicity, or manganism, share several pathological features of Parkinson's disease (PD). Biologically, Mn is an essential trace element, and Mn in the brain is preferentially localized in astrocytes. ...Mn overexposure can dysregulat …
The clinical symptoms of Mn neurotoxicity, or manganism, share several pathological features of Parkinson's disease (PD). Biol …
Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release.
Mahmoud S, Gharagozloo M, Simard C, Gris D. Mahmoud S, et al. Cells. 2019 Feb 20;8(2):184. doi: 10.3390/cells8020184. Cells. 2019. PMID: 30791579 Free PMC article. Review.
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic. ...Also, we review the main features of glutama …
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, …
Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells.
Lee WJ, Ham SA, Yoo H, Hwang JS, Yoo T, Paek KS, Lim DS, Han SG, Lee CH, Hong K, Seo HG. Lee WJ, et al. J Cell Biochem. 2018 Jul;119(7):5609-5619. doi: 10.1002/jcb.26732. Epub 2018 Mar 12. J Cell Biochem. 2018. PMID: 29388693
However, the regulatory mechanisms underlying this glutamate release are poorly understood. Here, we show that peroxisome proliferator-activated receptor delta (PPARδ) modulates neurotoxicity by inhibiting glutamate release in lipopolysaccharide (LPS)-activat …
However, the regulatory mechanisms underlying this glutamate release are poorly understood. Here, we show that peroxisome proliferato …
Estrogen receptors' neuroprotective effect against glutamate-induced neurotoxicity.
Lan YL, Zhao J, Li S. Lan YL, et al. Neurol Sci. 2014 Nov;35(11):1657-62. doi: 10.1007/s10072-014-1937-8. Epub 2014 Sep 17. Neurol Sci. 2014. PMID: 25228013 Review.
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (AD) has been gradually becoming elucidated recently. ...Extensive studies have indicated the neuroprotective effects of ERs against glutamate-induced neurotoxicity. The pur …
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (AD) has been gradually becoming elucidated rec …
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