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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1969 1
1971 1
1972 1
1974 1
1976 3
1977 5
1978 6
1979 1
1980 4
1981 20
1982 11
1983 8
1984 15
1985 21
1986 25
1987 11
1988 17
1989 14
1990 27
1991 29
1992 32
1993 63
1994 56
1995 54
1996 60
1997 73
1998 106
1999 99
2000 108
2001 124
2002 114
2003 127
2004 147
2005 134
2006 179
2007 157
2008 175
2009 179
2010 165
2011 164
2012 177
2013 161
2014 182
2015 146
2016 158
2017 129
2018 127
2019 138
2020 138
2021 138
2022 123
2023 95
2024 114
2025 125
2026 71

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4,082 results

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Page 1
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration.
Andersen JV, Markussen KH, Jakobsen E, Schousboe A, Waagepetersen HS, Rosenberg PA, Aldana BI. Andersen JV, et al. Neuropharmacology. 2021 Sep 15;196:108719. doi: 10.1016/j.neuropharm.2021.108719. Epub 2021 Jul 15. Neuropharmacology. 2021. PMID: 34273389 Free article. Review.
The recycling of glutamate is closely linked to brain energy metabolism and is essential to sustain glutamatergic neurotransmission. However, a considerable amount of glutamate is also metabolized and serves as a metabolic hub connecting glucose and amino …
The recycling of glutamate is closely linked to brain energy metabolism and is essential to sustain glutamatergic neurotransmission. …
Cancer metabolism: a therapeutic perspective.
Martinez-Outschoorn UE, Peiris-Pagés M, Pestell RG, Sotgia F, Lisanti MP. Martinez-Outschoorn UE, et al. Nat Rev Clin Oncol. 2017 Jan;14(1):11-31. doi: 10.1038/nrclinonc.2016.60. Epub 2016 May 4. Nat Rev Clin Oncol. 2017. PMID: 27141887 Review.
In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, and fatty acids at much higher rates than their nontumour equivalents; however, the metabolic ecology of tumours is complex because they contain multiple metaboli …
In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, and fatty acids at much higher r …
Neonatal Hypoglycemia and Brain Vulnerability.
De Angelis LC, Brigati G, Polleri G, Malova M, Parodi A, Minghetti D, Rossi A, Massirio P, Traggiai C, Maghnie M, Ramenghi LA. De Angelis LC, et al. Front Endocrinol (Lausanne). 2021 Mar 16;12:634305. doi: 10.3389/fendo.2021.634305. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33796072 Free PMC article. Review.
A transient reduction in blood glucose values is part of a transitional metabolic adaptation following birth, which resolves within the first 48 to 72 h of life. In addition, several factors may interfere with glucose homeostasis, especially in case of limited metabolic …
A transient reduction in blood glucose values is part of a transitional metabolic adaptation following birth, which resolves within t …
Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests.
Masoodi M, Gastaldelli A, Hyötyläinen T, Arretxe E, Alonso C, Gaggini M, Brosnan J, Anstee QM, Millet O, Ortiz P, Mato JM, Dufour JF, Orešič M. Masoodi M, et al. Nat Rev Gastroenterol Hepatol. 2021 Dec;18(12):835-856. doi: 10.1038/s41575-021-00502-9. Epub 2021 Sep 10. Nat Rev Gastroenterol Hepatol. 2021. PMID: 34508238 Review.
In this Review, we provide an overview of the contribution of metabolomics and lipidomics in clinical studies to identify biomarkers associated with NAFLD and nonalcoholic steatohepatitis (NASH). ...Overall, the studies demonstrated alterations in amino acid meta …
In this Review, we provide an overview of the contribution of metabolomics and lipidomics in clinical studies to identify biomarkers …
Amyotrophic Lateral Sclerosis: Pathophysiological Mechanisms and Treatment Strategies (Part 2).
Tolochko C, Shiryaeva O, Alekseeva T, Dyachuk V. Tolochko C, et al. Int J Mol Sci. 2025 May 29;26(11):5240. doi: 10.3390/ijms26115240. Int J Mol Sci. 2025. PMID: 40508048 Free PMC article. Review.
Over the past decade, understanding of the key pathogenetic links of ALS, including glutamate-mediated excitotoxicity and oxidative stress, has significantly advanced. This review considers the recent evidence on molecular mechanisms of these processes, as well as the ther …
Over the past decade, understanding of the key pathogenetic links of ALS, including glutamate-mediated excitotoxicity and oxidative stress, …
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Bak LK, Schousboe A, Waagepetersen HS. Bak LK, et al. J Neurochem. 2006 Aug;98(3):641-53. doi: 10.1111/j.1471-4159.2006.03913.x. Epub 2006 Jun 19. J Neurochem. 2006. PMID: 16787421 Free article. Review.
Neurons are metabolically handicapped in the sense that they are not able to perform de novo synthesis of neurotransmitter glutamate and gamma-aminobutyric acid (GABA) from glucose. ...In return, astrocytes release glutamine to be taken up into neurons for use as ne …
Neurons are metabolically handicapped in the sense that they are not able to perform de novo synthesis of neurotransmitter glutamate …
Microbial production of poly-gamma-glutamic acid.
Sirisansaneeyakul S, Cao M, Kongklom N, Chuensangjun C, Shi Z, Chisti Y. Sirisansaneeyakul S, et al. World J Microbiol Biotechnol. 2017 Sep 5;33(9):173. doi: 10.1007/s11274-017-2338-y. World J Microbiol Biotechnol. 2017. PMID: 28875418 Review.
Poly-gamma-glutamic acid (gamma-PGA) is a natural, biodegradable and water-soluble biopolymer of glutamic acid. ...In view of its commercial importance, the emphasis is on L-glutamic acid independent producers (i.e. microorganisms that do …
Poly-gamma-glutamic acid (gamma-PGA) is a natural, biodegradable and water-soluble biopolymer of glutamic acid. …
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle.
Andersen JV, Schousboe A, Verkhratsky A. Andersen JV, et al. Prog Neurobiol. 2022 Oct;217:102331. doi: 10.1016/j.pneurobio.2022.102331. Epub 2022 Jul 21. Prog Neurobiol. 2022. PMID: 35872221 Review.
Neurotransmitter recycling is intimately linked to astrocyte energy metabolism. In the course of AD, astrocytes undergo extensive metabolic remodeling, which may profoundly affect the glutamate/GABA-glutamine cycle. The consequences of altered astrocyte function and …
Neurotransmitter recycling is intimately linked to astrocyte energy metabolism. In the course of AD, astrocytes undergo extensive …
Glutamate Release.
Hackett JT, Ueda T. Hackett JT, et al. Neurochem Res. 2015 Dec;40(12):2443-60. doi: 10.1007/s11064-015-1622-1. Epub 2015 May 27. Neurochem Res. 2015. PMID: 26012367 Review.
Our aim was to review the processes of glutamate release from both biochemical and neurophysiological points of view. ...
Our aim was to review the processes of glutamate release from both biochemical and neurophysiological points of view. ...
Nonessential amino acid metabolism in breast cancer.
Geck RC, Toker A. Geck RC, et al. Adv Biol Regul. 2016 Sep;62:11-17. doi: 10.1016/j.jbior.2016.01.001. Epub 2016 Jan 21. Adv Biol Regul. 2016. PMID: 26838061 Review.
This review will focus on four nonessential amino acid metabolism pathways: glutamine-glutamate, serine-glycine, cysteine, and arginine-proline metabolism. ...The review will also discuss features of nonessential amino acid metabolism …
This review will focus on four nonessential amino acid metabolism pathways: glutamine-glutamate, serine-glycine, cystei …
4,082 results