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Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation.
Carr EL, Kelman A, Wu GS, Gopaul R, Senkevitch E, Aghvanyan A, Turay AM, Frauwirth KA. Carr EL, et al. J Immunol. 2010 Jul 15;185(2):1037-44. doi: 10.4049/jimmunol.0903586. Epub 2010 Jun 16. J Immunol. 2010. PMID: 20554958 Free PMC article.
Activation of a naive T cell is a highly energetic event, which requires a substantial increase in nutrient metabolism. ...Although amino acids are the basic building blocks of protein biosynthesis and contribute to many other metabolic processes, the role of amino …
Activation of a naive T cell is a highly energetic event, which requires a substantial increase in nutrient metabolism. ...Alt …
T Cell Activation Depends on Extracellular Alanine.
Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MC. Ron-Harel N, et al. Cell Rep. 2019 Sep 17;28(12):3011-3021.e4. doi: 10.1016/j.celrep.2019.08.034. Cell Rep. 2019. PMID: 31533027 Free PMC article.
T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine. ...Here, we show that extracellular alanine is nevertheless required fo …
T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the …
Dietary glutamine enhances murine T-lymphocyte responsiveness.
Kew S, Wells SM, Yaqoob P, Wallace FA, Miles EA, Calder PC. Kew S, et al. J Nutr. 1999 Aug;129(8):1524-31. doi: 10.1093/jn/129.8.1524. J Nutr. 1999. PMID: 10419985
The control diet included 200 g casein/kg, providing 19.6 g glutamine/kg; the glutamine-enriched diet provided 54.8 g glutamine/kg partly at the expense of casein; and the alanine + glycine-enriched diet provided 13.3 g glutamine/kg. ...Taken to …
The control diet included 200 g casein/kg, providing 19.6 g glutamine/kg; the glutamine-enriched diet provided 54.8 g gluta …
Metabolomic signatures in liquid biopsy are associated with overall survival in metastatic melanoma patients treated with immune checkpoint inhibitor therapy.
Costantini S, Madonna G, Capone M, Di Gennaro E, Bagnara P, Renza F, Mallardo D, Affatato R, Vitagliano C, Romanelli M, Tuffanelli M, Simeone E, Ciliberto G, Ascierto PA, Budillon A. Costantini S, et al. J Exp Clin Cancer Res. 2025 Apr 10;44(1):119. doi: 10.1186/s13046-025-03378-8. J Exp Clin Cancer Res. 2025. PMID: 40211360 Free PMC article.
BACKGROUND: Immune checkpoint inhibitors (ICIs), such as anti-Cytotoxic T-Lymphocyte Antigen 4(CTLA-4) and anti-Programmed cell death protein 1 (PD-1) agents, have improved the prognosis of patients with metastatic melanoma. ...Specifically, lactate, tryptoph …
BACKGROUND: Immune checkpoint inhibitors (ICIs), such as anti-Cytotoxic T-Lymphocyte Antigen 4(CTLA-4) and anti-Programmed …
Quantitative aspects of glucose and glutamine metabolism by intestinal cells.
Newsholme EA, Carrié AL. Newsholme EA, et al. Gut. 1994 Jan;35(1 Suppl):S13-7. doi: 10.1136/gut.35.1_suppl.s13. Gut. 1994. PMID: 8125383 Free PMC article.
The end products of glutamine metabolism by incubated gut preparations in vitro (mainly alanine), suggests that enterocytes, not immune cells, are responsible for most gut glutamine metabolism. ...Sepsis reduces rates of glucose and gl …
The end products of glutamine metabolism by incubated gut preparations in vitro (mainly alanine), suggests that enteroc …
Procyanidin B2 3,3"-di-O-gallate suppresses IFN-gamma production in murine CD4(+) T cells through the regulation of glutamine influx via direct interaction with ASCT2.
Endo K, Sawa T, Kitamura H, Umezawa K, Makabe H, Tanaka S. Endo K, et al. Int Immunopharmacol. 2023 Feb;115:109617. doi: 10.1016/j.intimp.2022.109617. Epub 2022 Dec 23. Int Immunopharmacol. 2023. PMID: 36566519
Several amino acids play critical roles in T cell activation, especially glutamine, which is important in mTOR signaling and interferon-gamma (IFN-gamma) production in CD4(+) T cells. ...In the present study, the mechanisms underlying the inhibitory effect of PCB2DG …
Several amino acids play critical roles in T cell activation, especially glutamine, which is important in mTOR signaling and i …
HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase.
Dong Y, Demaria S, Sun X, Santori FR, Jesdale BM, De Groot AS, Rom WN, Bushkin Y. Dong Y, et al. Infect Immun. 2004 Apr;72(4):2412-5. doi: 10.1128/IAI.72.4.2412-2415.2004. Infect Immun. 2004. PMID: 15039371 Free PMC article.
Major histocompatibility complex class I-restricted CD8(+) cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobact …
Major histocompatibility complex class I-restricted CD8(+) cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity …
Metabolic plasticity in CLL: adaptation to the hypoxic niche.
Koczula KM, Ludwig C, Hayden R, Cronin L, Pratt G, Parry H, Tennant D, Drayson M, Bunce CM, Khanim FL, Günther UL. Koczula KM, et al. Leukemia. 2016 Jan;30(1):65-73. doi: 10.1038/leu.2015.187. Epub 2015 Jul 23. Leukemia. 2016. PMID: 26202928 Free PMC article.
We have used a nuclear magnetic resonance based approach to monitor metabolism in living primary chronic lymphoid leukemia (CLL) cells and to interrogate their real-time metabolic responses to hypoxia. ...Finally, we identified a marked association of slower resting glucos …
We have used a nuclear magnetic resonance based approach to monitor metabolism in living primary chronic lymphoid leukemia (CLL) cell …
Stable integration vector for nutrient broth-based selection of attenuated Listeria monocytogenes strains with recombinant antigen expression.
Lenz LL, Huang WA, Zhou C, Li Z, Calendar R. Lenz LL, et al. Clin Vaccine Immunol. 2008 Sep;15(9):1414-9. doi: 10.1128/CVI.00208-08. Epub 2008 Jul 23. Clin Vaccine Immunol. 2008. PMID: 18650400 Free PMC article.
Recombinant Listeria monocytogenes strains induce strong cellular immune responses and may prove useful for antigen delivery for the vaccination of humans. ...The selectable markers in pPL2dalGlnA are glutamine synthetase (GlnA) and alanine racemase (D …
Recombinant Listeria monocytogenes strains induce strong cellular immune responses and may prove useful for antigen delivery for the …
Effects of glutamine supplementation on patients undergoing abdominal surgery.
Fan YP, Yu JC, Kang WM, Zhang Q. Fan YP, et al. Chin Med Sci J. 2009 Mar;24(1):55-9. doi: 10.1016/s1001-9294(09)60060-2. Chin Med Sci J. 2009. PMID: 19382426 Clinical Trial.
OBJECTIVE: To evaluate the effects of supplementation of glutamine (GLN) on maintaining glutathione (GSH) level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. ...Blood sample was taken on preoperative day, an …
OBJECTIVE: To evaluate the effects of supplementation of glutamine (GLN) on maintaining glutathione (GSH) level, immune system …
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