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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 1
1968 3
1972 2
1974 1
1975 4
1976 3
1977 9
1978 7
1979 3
1980 3
1981 2
1982 13
1983 5
1984 14
1985 14
1986 11
1987 12
1988 10
1989 14
1990 19
1991 22
1992 20
1993 27
1994 22
1995 20
1996 23
1997 27
1998 34
1999 30
2000 19
2001 26
2002 30
2003 25
2004 26
2005 26
2006 36
2007 35
2008 34
2009 30
2010 28
2011 32
2012 32
2013 48
2014 34
2015 41
2016 43
2017 48
2018 50
2019 50
2020 46
2021 41
2022 50
2023 51
2024 54
2025 67
2026 25

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1,288 results

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Page 1
Macrophage-derived glutamine boosts satellite cells and muscle regeneration.
Shang M, Cappellesso F, Amorim R, Serneels J, Virga F, Eelen G, Carobbio S, Rincon MY, Maechler P, De Bock K, Ho PC, Sandri M, Ghesquière B, Carmeliet P, Di Matteo M, Berardi E, Mazzone M. Shang M, et al. Nature. 2020 Nov;587(7835):626-631. doi: 10.1038/s41586-020-2857-9. Epub 2020 Oct 28. Nature. 2020. PMID: 33116312 Free PMC article.
Here we show, in a mouse model, that muscle injuries and ageing are characterized by intra-tissue restrictions of glutamine. Low levels of glutamine endow macrophages with the metabolic ability to secrete glutamine via enhanced glutamine synthetase (GS …
Here we show, in a mouse model, that muscle injuries and ageing are characterized by intra-tissue restrictions of glutamine. Low leve …
A glutamine metabolic switch supports erythropoiesis.
Lyu J, Gu Z, Zhang Y, Vu HS, Lechauve C, Cai F, Cao H, Keith J, Brancaleoni V, Granata F, Motta I, Cappellini MD, Huang LJ, DeBerardinis RJ, Weiss MJ, Ni M, Xu J. Lyu J, et al. Science. 2024 Nov 15;386(6723):eadh9215. doi: 10.1126/science.adh9215. Epub 2024 Nov 15. Science. 2024. PMID: 39541460 Free PMC article.
Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. Glutamine syntheta …
Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete …
Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes.
Lu TL, Zheng AC, Suzuki K, Lu CC, Wang CY, Fang SH. Lu TL, et al. J Int Soc Sports Nutr. 2024 Dec;21(1):2300259. doi: 10.1080/15502783.2023.2300259. Epub 2024 Jan 9. J Int Soc Sports Nutr. 2024. PMID: 38193521 Free PMC article. Clinical Trial.
BACKGROUND: Maintaining proper immune function and hormone status is important for athletes to avoid upper respiratory tract infection (URTI) and insufficient recovery, which is detrimental to sport performance and health. The aim of this study was to evaluate whether thre …
BACKGROUND: Maintaining proper immune function and hormone status is important for athletes to avoid upper respiratory tract infection (URTI …
Identification of glutamine as a potential therapeutic target in dry eye disease.
Chen X, Zhang C, Peng F, Wu L, Zhuo D, Wang L, Zhang M, Li Z, Tian L, Jie Y, Huang Y, Yang X, Li X, Lei F, Cheng Y. Chen X, et al. Signal Transduct Target Ther. 2025 Jan 22;10(1):27. doi: 10.1038/s41392-024-02119-1. Signal Transduct Target Ther. 2025. PMID: 39837870 Free PMC article.
In situ metabolomics through matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased glutamine levels in cornea following MSC + Tbeta4 combined therapy. Inhibition of glutamine reversed the anti-inflammatory, anti-apoptot …
In situ metabolomics through matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased glutami …
A discrete neuronal circuit induces a hibernation-like state in rodents.
Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T. Takahashi TM, et al. Nature. 2020 Jul;583(7814):109-114. doi: 10.1038/s41586-020-2163-6. Epub 2020 Jun 11. Nature. 2020. PMID: 32528181
There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian sp …
There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could en …
Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states.
Jaschke NP, Luchsinger JR, Chen Z, Wulfmeyer VC, de la Rosa X, Hahn O, Zhang C, Bachtel ND, Cullen JL, Rachner TD, Medzhitov R, Rinschen MM, Wu C, Wang A. Jaschke NP, et al. Cell. 2025 Dec 24;188(26):7481-7494.e16. doi: 10.1016/j.cell.2025.10.005. Epub 2025 Nov 4. Cell. 2025. PMID: 41192423 Free PMC article.
We identified three amino acids-glutamine (Q), lysine (K), and threonine (T)-within dietary protein, which are necessary and sufficient for protein aversion during recovery from catabolic states. ...In summary, we identified a set of adaptive food preferences during …
We identified three amino acids-glutamine (Q), lysine (K), and threonine (T)-within dietary protein, which are necessary and sufficie …
Pharmaconutrition: Which substrates?
Gianotti L, Nespoli L, Sandini M. Gianotti L, et al. Eur J Surg Oncol. 2024 May;50(5):106798. doi: 10.1016/j.ejso.2022.12.003. Epub 2022 Dec 11. Eur J Surg Oncol. 2024. PMID: 36526494
To achieve these goals, these substrates have to be administered with over physiologic dose. Glutamine and omega-3 polyunsaturated fatty acids, used as single substrate, did not show clear clinical advantages on solid endpoints such as postoperative complications. ...In a …
To achieve these goals, these substrates have to be administered with over physiologic dose. Glutamine and omega-3 polyunsaturated fa …
Glutamine and alanyl-glutamine accelerate the recovery from 5-fluorouracil-induced experimental oral mucositis in hamster.
Leitão RF, Ribeiro RA, Lira AM, Silva LR, Bellaguarda EA, Macedo FD, Sousa RB, Brito GA. Leitão RF, et al. Cancer Chemother Pharmacol. 2008 Feb;61(2):215-22. doi: 10.1007/s00280-007-0463-2. Epub 2007 Apr 11. Cancer Chemother Pharmacol. 2008. PMID: 17426972
INTRODUCTION: Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side effect of cancer therapy. AIM: To evaluate the effect of oral glutamine and alanyl-glutamine, a more stable glutamine derivative, on 5-FU-induced oral muco …
INTRODUCTION: Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side effect of cancer therapy. AIM: To ev …
Evaluation of the recovery after heart surgery following preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, L-arginine, and L-glutamine: a double-blind randomized placebo-controlled clinical trial.
Norouzi M, Nadjarzadeh A, Maleki M, Khayyatzadeh SS, Hosseini S, Yaseri M, Fattahi H. Norouzi M, et al. Trials. 2022 Aug 13;23(1):649. doi: 10.1186/s13063-022-06621-1. Trials. 2022. PMID: 35964137 Free PMC article. Clinical Trial.
In some medical conditions, supplementation with a combination of L-glutamine (Gln), beta-hydroxy-beta-methylbutyrate (HMB), and L-arginine (Arg) had promising effects on improving recovery. ...CONCLUSION: The present study showed that perioperative supplementation …
In some medical conditions, supplementation with a combination of L-glutamine (Gln), beta-hydroxy-beta-methylbutyrate (HMB), and L-ar …
Glutamine Supplementation and Exercise: A Narrative Review of Biochemical Mechanisms and Timing Strategies.
Djordjevic B, Stojiljkovic V, Velickov A, Kocic J, Milenkovic J, Veljkovic A, Basic J, Cvetkovic T. Djordjevic B, et al. Medicina (Kaunas). 2026 Feb 6;62(2):329. doi: 10.3390/medicina62020329. Medicina (Kaunas). 2026. PMID: 41752728 Free PMC article. Review.
It is required in the biosynthesis of neurotransmitters, nucleotides, nicotinamide-derived coenzymes, glutathione, and hexosamines, making it a candidate for supporting exercise recovery. In addition, glutamine may support key mechanisms involved in muscle adaptatio …
It is required in the biosynthesis of neurotransmitters, nucleotides, nicotinamide-derived coenzymes, glutathione, and hexosamines, making i …
1,288 results