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Multifunctional Enzymes as Targets for the Treatment of Tuberculosis: Paving the Way for New Anti-TB Drugs.
Teixeira CSS, Cerqueira NMFSA, Sousa SF. Teixeira CSS, et al. Curr Med Chem. 2021;28(28):5847-5882. doi: 10.2174/0929867328666201229122722. Curr Med Chem. 2021. PMID: 33372865 Review.
This work summarizes recent developments on anti-TB therapy, starting by discussing the current epidemiologic status and presenting an overview of the history of anti-tuberculosis drug discovery. Special attention is dedicated to five multifunctional enzymes that ar …
This work summarizes recent developments on anti-TB therapy, starting by discussing the current epidemiologic status and presenting an overv …
Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future.
Avramis VI, Panosyan EH. Avramis VI, et al. Clin Pharmacokinet. 2005;44(4):367-93. doi: 10.2165/00003088-200544040-00003. Clin Pharmacokinet. 2005. PMID: 15828851 Review.
The asparaginases of bacterial origin induce anti-asparaginase neutralising antibodies in a large proportion of patients (44-60%), thus negating the specific enzymatic activity and resulting in failure of the target amino acid deamination in serum. There is immunolo …
The asparaginases of bacterial origin induce anti-asparaginase neutralising antibodies in a large proportion of patients (44-60%), thus nega …
Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women.
Huang T, Balasubramanian R, Yao Y, Clish CB, Shadyab AH, Liu B, Tworoger SS, Rexrode KM, Manson JE, Kubzansky LD, Hankinson SE. Huang T, et al. Mol Psychiatry. 2021 Jul;26(7):3315-3327. doi: 10.1038/s41380-020-00870-9. Epub 2020 Aug 28. Mol Psychiatry. 2021. PMID: 32859999 Free PMC article.
Recent animal and small clinical studies have suggested depression is related to altered lipid and amino acid profiles. However, this has not been examined in a population-based sample, particularly in women. ...Positive depression status was defined as having any o …
Recent animal and small clinical studies have suggested depression is related to altered lipid and amino acid profiles. Howeve …
How Glutamate and GABA «Became» Neurotransmitters: Personal Account of a 65 Years' Voyage.
Storm-Mathisen J. Storm-Mathisen J. J Neurochem. 2026 Apr;170(4):e70325. doi: 10.1111/jnc.70325. J Neurochem. 2026. PMID: 41906358
We showed for the first time that GABA in the brain is synthesised selectively in inhibitory neurons (1969 -) and that glutamate uptake labels selectively putative glutamatergic nerve endings (1976 -). Then I made antibodies to amino acids (1982 -) and showed that g …
We showed for the first time that GABA in the brain is synthesised selectively in inhibitory neurons (1969 -) and that glutamate uptake labe …
Plasma cell membrane glycoprotein 1 (PC-1): a marker of insulin resistance in obesity, uremia and diabetes mellitus.
Stefanović V, Antić S. Stefanović V, et al. Clin Lab. 2004;50(5-6):271-8. Clin Lab. 2004. PMID: 15209435 Review.
This was a DNA polymorphism in exon 4 that causes an amino acid change from lysine to glutamine at codon 121 (K121Q). PC-1 121Q allele might predispose independently of other well established risk factors for early myocardial infarction. ...The great potentia …
This was a DNA polymorphism in exon 4 that causes an amino acid change from lysine to glutamine at codon 121 (K121Q). P …
Newborn metabolomics linking prenatal air pollution exposure and autism spectrum disorder risk in children.
Kang N, Yang Z, Petrick LM, Rahman MM, Pavlovic N, Lurmann FW, Martinez MP, Yu X, Chow T, Eckel SP, Schwartz J, Chen JC, McConnell R, Xiang AH, Chen Z. Kang N, et al. J Expo Sci Environ Epidemiol. 2026 Apr 27. doi: 10.1038/s41370-026-00897-0. Online ahead of print. J Expo Sci Environ Epidemiol. 2026. PMID: 42045584
SIGNIFICANCE: This study reveals dysregulated neonatal amino acid metabolism as a potential mechanism 49 connecting prenatal air pollution exposure to increased ASD risk. ...IMPACT STATEMENT: This study demonstrates that prenatal exposure to air pollution-specifical …
SIGNIFICANCE: This study reveals dysregulated neonatal amino acid metabolism as a potential mechanism 49 connecting prenatal a …
Polyglutamine variation in a flowering time protein correlates with island age in a Hawaiian plant radiation.
Lindqvist C, Laakkonen L, Albert VA. Lindqvist C, et al. BMC Evol Biol. 2007 Jul 2;7:105. doi: 10.1186/1471-2148-7-105. BMC Evol Biol. 2007. PMID: 17605781 Free PMC article.
BACKGROUND: A controversial topic in evolutionary developmental biology is whether morphological diversification in natural populations can be driven by expansions and contractions of amino acid repeats in proteins. To promote adaptation, selection on protein length …
BACKGROUND: A controversial topic in evolutionary developmental biology is whether morphological diversification in natural populations can …