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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 6
1971 2
1972 2
1973 3
1974 2
1975 4
1976 3
1977 1
1979 3
1980 4
1981 3
1982 4
1983 7
1984 6
1985 3
1986 6
1987 2
1988 6
1989 3
1990 8
1991 3
1992 9
1993 15
1994 10
1995 8
1996 15
1997 14
1998 20
1999 21
2000 23
2001 13
2002 8
2003 9
2004 13
2005 9
2006 9
2007 15
2008 12
2009 11
2010 13
2011 13
2012 22
2013 12
2014 17
2015 22
2016 18
2017 15
2018 24
2019 17
2020 25
2021 24
2022 12
2023 13
2024 21
2025 39
2026 26

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609 results

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Page 1
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation.
Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Cruzat V, et al. Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564. Nutrients. 2018. PMID: 30360490 Free PMC article. Review.
Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption by immune cells is similar or greater than glucose. ...Therefore, this paper provides an integrated review of how glutamine me …
Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption …
The effect of glutamine supplementation on athletic performance, body composition, and immune function: A systematic review and a meta-analysis of clinical trials.
Ramezani Ahmadi A, Rayyani E, Bahreini M, Mansoori A. Ramezani Ahmadi A, et al. Clin Nutr. 2019 Jun;38(3):1076-1091. doi: 10.1016/j.clnu.2018.05.001. Epub 2018 May 9. Clin Nutr. 2019. PMID: 29784526
There was no association between glutamine ingestion and other outcomes investigated. CONCLUSION: According to this meta-analysis, generally, glutamine supplementation has no effect on athletics immune system, aerobic performance, and body composition. …
There was no association between glutamine ingestion and other outcomes investigated. CONCLUSION: According to this meta-analysis, ge …
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.
The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvironment of tumors. ...By contrast, effector T cells …
The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a …
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity.
Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, Sun X, Saravia J, Rankin S, Dhungana Y, Chi H. Guo C, et al. Nature. 2023 Aug;620(7972):200-208. doi: 10.1038/s41586-023-06299-8. Epub 2023 Jul 5. Nature. 2023. PMID: 37407815 Free PMC article.
Mechanistically, tumour cells and cDC1s compete for glutamine uptake via the transporter SLC38A2 to tune anti-tumour immunity. Nutrient screening and integrative analyses show that glutamine is the dominant amino acid in promoting cDC1 function. Further, g …
Mechanistically, tumour cells and cDC1s compete for glutamine uptake via the transporter SLC38A2 to tune anti-tumour immunity. Nutrie …
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.
Huang D, Wang Y, Thompson JW, Yin T, Alexander PB, Qin D, Mudgal P, Wu H, Liang Y, Tan L, Pan C, Yuan L, Wan Y, Li QJ, Wang XF. Huang D, et al. Nat Cell Biol. 2022 Feb;24(2):230-241. doi: 10.1038/s41556-021-00820-9. Epub 2022 Feb 10. Nat Cell Biol. 2022. PMID: 35145222 Free PMC article.
Many cancers have an unusual dependence on glutamine. However, most previous studies have focused on the contribution of glutamine to metabolic building blocks and the energy supply. ...This GABA-mediated beta-catenin activation both stimulates tumour cell prolifera …
Many cancers have an unusual dependence on glutamine. However, most previous studies have focused on the contribution of glutamine …
A blueprint for tumor-infiltrating B cells across human cancers.
Ma J, Wu Y, Ma L, Yang X, Zhang T, Song G, Li T, Gao K, Shen X, Lin J, Chen Y, Liu X, Fu Y, Gu X, Chen Z, Jiang S, Rao D, Pan J, Zhang S, Zhou J, Huang C, Shi S, Fan J, Guo G, Zhang X, Gao Q. Ma J, et al. Science. 2024 May 3;384(6695):eadj4857. doi: 10.1126/science.adj4857. Epub 2024 May 3. Science. 2024. PMID: 38696569
B lymphocytes are essential mediators of humoral immunity and play multiple roles in human cancer. ...The dysfunctional extrafollicular program was associated with glutamine-derived metabolites through epigenetic-metabolic cross-talk, which promoted a T cell-driven …
B lymphocytes are essential mediators of humoral immunity and play multiple roles in human cancer. ...The dysfunctional extrafollicul …
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Edwards DN, et al. J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100. J Clin Invest. 2021. PMID: 33320840 Free PMC article.
The glutamine transporter inhibitor V-9302 selectively blocked glutamine uptake by TNBC cells but not CD8+ T cells, driving synthesis of glutathione, a major cellular antioxidant, to improve CD8+ T cell effector function. We propose a "glutamine steal" …
The glutamine transporter inhibitor V-9302 selectively blocked glutamine uptake by TNBC cells but not CD8+ T cells, driving sy …
A human autoimmune organoid model reveals IL-7 function in coeliac disease.
Santos AJM, van Unen V, Lin Z, Chirieleison SM, Ha N, Batish A, Chan JE, Cedano J, Zhang ET, Mu Q, Guh-Siesel A, Tomaske M, Colburg D, Varma S, Choi SS, Christophersen A, Baghdasaryan A, Yost KE, Karlsson K, Ha A, Li J, Dai H, Sellers ZM, Chang HY, Dunn JCY, Zhang BM, Mellins ED, Sollid LM, Fernandez-Becker NQ, Davis MM, Kuo CJ. Santos AJM, et al. Nature. 2024 Aug;632(8024):401-410. doi: 10.1038/s41586-024-07716-2. Epub 2024 Jul 24. Nature. 2024. PMID: 39048815 Free PMC article.
In vitro models of autoimmunity are constrained by an inability to culture affected epithelium alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is an autoimmune disease in which dietary gluten-derived peptides bind to the major histocomp …
In vitro models of autoimmunity are constrained by an inability to culture affected epithelium alongside the complex tissue-resident immu …
myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
Fang H, Dai W, Gu R, Zhang Y, Li J, Luo W, Tong S, Han L, Wang Y, Jiang C, Wang X, Wang R, Cai G. Fang H, et al. J Hematol Oncol. 2024 Dec 18;17(1):126. doi: 10.1186/s13045-024-01643-5. J Hematol Oncol. 2024. PMID: 39696364 Free PMC article.
In vivo and in vitro assays confirmed PWAR6's roles in CRC cell stemness, migration, and glutamine uptake. RNA pulldown, RIP, and Co-IP assays investigated the molecular mechanisms of the PWAR6/NRF2/SLC38A2 signaling axis in CRC progression, flow cytometry was used to asse …
In vivo and in vitro assays confirmed PWAR6's roles in CRC cell stemness, migration, and glutamine uptake. RNA pulldown, RIP, and Co- …
NaCl enhances CD8+ T cell effector functions in cancer immunotherapy.
Scirgolea C, Sottile R, De Luca M, Susana A, Carnevale S, Puccio S, Ferrari V, Lise V, Contarini G, Scarpa A, Scamardella E, Feno S, Camisaschi C, De Simone G, Basso G, Giuliano D, Mazza EMC, Gattinoni L, Roychoudhuri R, Voulaz E, Di Mitri D, Simonelli M, Losurdo A, Pozzi D, Tsui C, Kallies A, Timo S, Martano G, Barberis E, Manfredi M, Rescigno M, Jaillon S, Lugli E. Scirgolea C, et al. Nat Immunol. 2024 Oct;25(10):1845-1857. doi: 10.1038/s41590-024-01923-9. Epub 2024 Aug 28. Nat Immunol. 2024. PMID: 39198631
In mice, a high-salt diet reduced the growth of experimental tumors in a CD8(+) T cell-dependent manner by inhibiting terminal differentiation and enhancing the effector potency of CD8(+) T cells. Mechanistically, NaCl enhanced glutamine consumption, which was critical for …
In mice, a high-salt diet reduced the growth of experimental tumors in a CD8(+) T cell-dependent manner by inhibiting terminal differentiati …
609 results