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Huntington's disease: the current state of research with peripheral tissues.
Sassone J, Colciago C, Cislaghi G, Silani V, Ciammola A. Sassone J, et al. Exp Neurol. 2009 Oct;219(2):385-97. doi: 10.1016/j.expneurol.2009.05.012. Epub 2009 May 19. Exp Neurol. 2009. PMID: 19460373 Review.
Huntington's disease (HD) is a genetically dominant condition caused by expanded CAG repeats. These repeats code for a glutamine tract in the HD gene product huntingtin (htt), which is a protein expressed in almost all tissues. Although most HD symptoms reflect pref …
Huntington's disease (HD) is a genetically dominant condition caused by expanded CAG repeats. These repeats code for a glutamine …
Diabetes and branched-chain amino acids: What is the link?
Bloomgarden Z. Bloomgarden Z. J Diabetes. 2018 May;10(5):350-352. doi: 10.1111/1753-0407.12645. Epub 2018 Feb 13. J Diabetes. 2018. PMID: 29369529
Similarly, higher BCAA levels track with cardiovascular disease. [Figure: see text] The metabolism of BCAA involves two processes: (i) a reversible process catalysed by a branched-chain aminotransferase (BCAT), either cytosolic or mitochondrial, requiring pyridoxal …
Similarly, higher BCAA levels track with cardiovascular disease. [Figure: see text] The metabolism of BCAA involves two proces …
The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.
Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K. Chen J, et al. Mol Neurodegener. 2016 Aug 18;11(1):60. doi: 10.1186/s13024-016-0127-y. Mol Neurodegener. 2016. PMID: 27538496 Free PMC article.
BACKGROUND: Our previous studies of Alzheimer's disease (AD) suggested that glutamine broadly improves cellular readiness to respond to stress and acts as a neuroprotectant both in vitro and in AD mouse models. ...RESULTS: Genetically ATM-deficient mice and wild typ …
BACKGROUND: Our previous studies of Alzheimer's disease (AD) suggested that glutamine broadly improves cellular readiness to r …
Chronic diarrhoea, weight loss and a positive anti-tissue transglutaminase antibody: A case report of olmesartan-induced enteropathy.
Sheppard R, Evanson B, Campbell I, Shand A. Sheppard R, et al. BMJ Case Rep. 2024 May 6;17(5):e255407. doi: 10.1136/bcr-2023-255407. BMJ Case Rep. 2024. PMID: 38719261 Free PMC article.
It can cause a sprue-like enteropathy (SLE), characterised by chronic diarrhoea, weight loss and villous atrophy. Transiently raised anti-tissue transglutaminase (ATTG) antibody has also been rarely reported in the literature.We describe the case of a woman in her m …
It can cause a sprue-like enteropathy (SLE), characterised by chronic diarrhoea, weight loss and villous atrophy. Transiently …
The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice.
Shao H, Dong L, Feng Y, Wang C, Tong H. Shao H, et al. BMC Pharmacol Toxicol. 2020 Oct 1;21(1):71. doi: 10.1186/s40360-020-00449-8. BMC Pharmacol Toxicol. 2020. PMID: 33004081 Free PMC article.
In the experimental mice, glutamine was given orally half an hour before they were administrated with cantharidin. ...RESULT: The results showed that L-glutamine (Gln) pretreatment reduced weight loss and mortality. It also decreased the biological mar …
In the experimental mice, glutamine was given orally half an hour before they were administrated with cantharidin. ...RESULT: The res …
L-Ornithine L-Aspartate (LOLA) as a Novel Approach for Therapy of Non-alcoholic Fatty Liver Disease.
Canbay A, Sowa JP. Canbay A, et al. Drugs. 2019 Feb;79(Suppl 1):39-44. doi: 10.1007/s40265-018-1020-5. Drugs. 2019. PMID: 30706422 Free PMC article.
NAFLD and the progressive form non-alcoholic steatohepatitis (NASH) are currently the leading causes of chronic liver disease worldwide, with roughly 25% of the world population affected by NAFLD. Consequences of NASH are end-stage liver disease and cardiovascula …
NAFLD and the progressive form non-alcoholic steatohepatitis (NASH) are currently the leading causes of chronic liver disease worldwi …
Toward a core nutraceutical program for cancer management.
McCarty MF, Block KI. McCarty MF, et al. Integr Cancer Ther. 2006 Jun;5(2):150-71. doi: 10.1177/1534735406288443. Integr Cancer Ther. 2006. PMID: 16685077 Free article. Review.
Mushroombeta-glucans and probiotic lactobacilli can amplify NK activity via stimulatory effects on macrophages. Selenium, beta-carotene, and glutamine can also increase the number and/or cytotoxic activity of NK cells. Cachectic loss of muscle mass can be opposed by …
Mushroombeta-glucans and probiotic lactobacilli can amplify NK activity via stimulatory effects on macrophages. Selenium, beta-carotene, and …
Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.
Oliver CN, Starke-Reed PE, Stadtman ER, Liu GJ, Carney JM, Floyd RA. Oliver CN, et al. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5144-7. doi: 10.1073/pnas.87.13.5144. Proc Natl Acad Sci U S A. 1990. PMID: 1973301 Free PMC article.
We also report that the free radical spin trap N-tert-butyl-alpha-phenylnitrone [300 mg/kg (body weight)] administered 60 min before ischemia/reperfusion is initiated, partially prevents protein oxidation and protects from loss of glutamine synthetase activit …
We also report that the free radical spin trap N-tert-butyl-alpha-phenylnitrone [300 mg/kg (body weight)] administered 60 min before …
[Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schonlein purpura].
Xiong LJ, Shang LH, Ou XQ, Li Y, Xie XL. Xiong LJ, et al. Zhongguo Dang Dai Er Ke Za Zhi. 2019 Feb;21(2):168-171. doi: 10.7499/j.issn.1008-8830.2019.02.012. Zhongguo Dang Dai Er Ke Za Zhi. 2019. PMID: 30782281 Free PMC article. Clinical Trial. Chinese.
Intravenous steroids were used according to the severity of disease in both groups. Other therapies were the same in the two groups. The two groups were compared in terms of the length of hospital stay, the rate and duration of use of intravenous steroids, the recurrence r …
Intravenous steroids were used according to the severity of disease in both groups. Other therapies were the same in the two groups. …
[Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): cardiac patient].
Jiménez Jiménez FJ, Cervera Montes M, Blesa Malpica AL; Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE). Jiménez Jiménez FJ, et al. Med Intensiva. 2011 Nov;35 Suppl 1:81-5. doi: 10.1016/S0210-5691(11)70017-1. Med Intensiva. 2011. PMID: 22309760 Free article. Spanish.
Patients with cardiac disease can develop two types of malnutrition: cardiac cachexia, which appears in chronic congestive heart failure, and malnutrition due to the complications of cardiac surgery or any other type of surgery in patients with heart disease. ...The …
Patients with cardiac disease can develop two types of malnutrition: cardiac cachexia, which appears in chronic congestive heart fail …
15 results