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Page 1
Glutamine depletion and increased gut permeability in nonanorectic, non-weight-losing tumor-bearing rats.
De Blaauw I, Deutz NE, van der Hulst RR, von Meyenfeldt MF. De Blaauw I, et al. Gastroenterology. 1997 Jan;112(1):118-26. doi: 10.1016/s0016-5085(97)70226-9. Gastroenterology. 1997. PMID: 8978350
The aim of this study was to test whether increasing tumor loads affect gut intracellular glutamine handling, protein turnover, and gut absorptive and barrier function. ...CONCLUSIONS: The presence of a methylcholantrene tumor leads to altered mucosal glut …
The aim of this study was to test whether increasing tumor loads affect gut intracellular glutamine handling, protein turnover …
L-Glutamine Substantially Improves 5-Fluorouracil-Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice.
Kuo YR, Lin CH, Lin WS, Pan MH. Kuo YR, et al. Mol Nutr Food Res. 2024 May;68(9):e2300704. doi: 10.1002/mnfr.202300704. Epub 2024 Apr 24. Mol Nutr Food Res. 2024. PMID: 38656560
METHODS AND RESULTS: Over twelve days, Institute of Cancer Research (ICR) mice are given low (0.5 mg kg(-1)) or high (2 mg kg(-1)) doses of L-Glutamine daily, with 5-FU (50 mg kg(-1)) administered between days six and nine. Mice receiving only 5-FU exhibited weight …
METHODS AND RESULTS: Over twelve days, Institute of Cancer Research (ICR) mice are given low (0.5 mg kg(-1)) or high (2 mg kg(-1)) doses of …
Nutrition and gastrointestinal disease.
O'Keefe SJ. O'Keefe SJ. Scand J Gastroenterol Suppl. 1996;220:52-9. doi: 10.3109/00365529609094750. Scand J Gastroenterol Suppl. 1996. PMID: 8898436 Review.
Nutrition and intestinal function are intimately interrelated. The chief purpose of the gut is to digest and absorb nutrients in order to maintain life. ...For example, recent studies of ours have shown that a weight loss of greater than 30% accompanyi …
Nutrition and intestinal function are intimately interrelated. The chief purpose of the gut is to digest and absorb nutrients …
Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.
Ye Y, Abulizi A, Zhang Y, Lu F, An Y, Ren C, Zhang H, Wang Y, Lin D, Lu D, Li M, Yang B. Ye Y, et al. Int J Mol Sci. 2025 Mar 10;26(6):2466. doi: 10.3390/ijms26062466. Int J Mol Sci. 2025. PMID: 40141109 Free PMC article.
Our experimental results showed that GA significantly ameliorated the body weight loss and disease activity index (DAI) of UC mice. GA significantly restored 11% of the colon length and 69% of the spleen index compared to UC mice. ...In conclusion, this study sugges …
Our experimental results showed that GA significantly ameliorated the body weight loss and disease activity index (DAI) of UC …
Prophylactic glutamine protects the intestinal mucosa from radiation injury.
Klimberg VS, Souba WW, Dolson DJ, Salloum RM, Hautamaki RD, Plumley DA, Mendenhall WM, Bova FJ, Khan SR, Hackett RL, et al. Klimberg VS, et al. Cancer. 1990 Jul 1;66(1):62-8. doi: 10.1002/1097-0142(19900701)66:1<62::aid-cncr2820660113>3.0.co;2-e. Cancer. 1990. PMID: 2354410
Glutamine may be an essential dietary component, especially for the support of intestinal mucosal growth and function. ...There was no difference in arterial glutamine or gut glutamine extraction between the two groups, but body weight …
Glutamine may be an essential dietary component, especially for the support of intestinal mucosal growth and function. ...Ther …
Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice.
Araújo CV, Lazzarotto CR, Aquino CC, Figueiredo IL, Costa TB, Alves LA, Ribeiro RA, Bertolini LR, Lima AA, Brito GA, Oriá RB. Araújo CV, et al. Braz J Med Biol Res. 2015 Jun;48(6):493-501. doi: 10.1590/1414-431X20144360. Epub 2015 Apr 28. Braz J Med Biol Res. 2015. PMID: 25945744 Free PMC article.
We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-trophic nutrient, during tissue recovery after 5-FU-induced intestinal mucositis. ...Crypt length, mitotic, apoptotic, and necrotic cr …
We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-t …
Inflammation rather than nutritional depletion determines glutamine concentrations and intestinal permeability.
Hulsewé KW, van der Hulst RW, van Acker BA, von Meyenfeldt MF, Soeters PB. Hulsewé KW, et al. Clin Nutr. 2004 Oct;23(5):1209-16. doi: 10.1016/j.clnu.2004.04.001. Clin Nutr. 2004. PMID: 15380915
AIM: Nutritional depletion has been correlated with low plasma and mucosal glutamine concentrations and with increased intestinal permeability. Since nutritional depletion often is associated with (chronic) inflammatory stress, this study was designed to establish t …
AIM: Nutritional depletion has been correlated with low plasma and mucosal glutamine concentrations and with increased intestinal …
Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota.
Chen H, Zhang F, Li R, Liu Y, Wang X, Zhang X, Xu C, Li Y, Guo Y, Yao Q. Chen H, et al. Biomed Pharmacother. 2020 Apr;124:109829. doi: 10.1016/j.biopha.2020.109829. Epub 2020 Jan 17. Biomed Pharmacother. 2020. PMID: 31958765 Free article.
Results showed that BBR treated rats displayed less weight loss, lower diarrhea score and longer colon length in 5-Fu treated rats. Meanwhile, BBR treatment significantly increased the expression of Occludin in ileum and decreased the d-lactate content in serum. ... …
Results showed that BBR treated rats displayed less weight loss, lower diarrhea score and longer colon length in 5-Fu treated …
Dietary Bioactive Peptide Alanyl-Glutamine Attenuates Dextran Sodium Sulfate-Induced Colitis by Modulating Gut Microbiota.
Xu Q, Hu M, Li M, Hou J, Zhang X, Gao Y, Chachar B, Li X. Xu Q, et al. Oxid Med Cell Longev. 2021 May 8;2021:5543003. doi: 10.1155/2021/5543003. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34046146 Free PMC article.
Inflammatory bowel disease (IBD) is a chronic intestinal disorder threatening human health. Di-peptide alanyl-glutamine (Ala-Gln) has various beneficial effects on gut health. ...The results showed that oral supplementation of Ala-Gln or Gln significantly att …
Inflammatory bowel disease (IBD) is a chronic intestinal disorder threatening human health. Di-peptide alanyl-glutamine (Ala-G …
Qingxie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-kappaB signaling in colorectal adenocarcinoma.
Jin Y, Lu L, Hua H, Chen B, Fang W, Lin K, Ren P, Geng Z, Wang L, Yan X, Chen W, Lin J. Jin Y, et al. Hereditas. 2025 Aug 29;162(1):178. doi: 10.1186/s41065-025-00541-1. Hereditas. 2025. PMID: 40883855 Free PMC article.
QFG treatment restored microbial balance, reduced pro-inflammatory cytokines TNF-alpha, IL-6, and enhanced intestinal barrier integrity by upregulating tight junction proteins ZO-1, Occludin, Calprotectin.Mechanistically, QFG rebalanced Th17/Treg cell ratios and suppressed …
QFG treatment restored microbial balance, reduced pro-inflammatory cytokines TNF-alpha, IL-6, and enhanced intestinal barrier integri …
22 results