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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1961 1
1962 2
1963 2
1964 5
1965 8
1966 1
1967 5
1968 8
1969 5
1970 10
1971 6
1972 6
1973 5
1974 14
1975 14
1976 13
1977 17
1978 14
1979 15
1980 21
1981 26
1982 31
1983 32
1984 37
1985 36
1986 41
1987 36
1988 47
1989 51
1990 66
1991 68
1992 73
1993 64
1994 58
1995 88
1996 87
1997 77
1998 93
1999 80
2000 96
2001 107
2002 113
2003 109
2004 132
2005 163
2006 182
2007 184
2008 198
2009 178
2010 220
2011 191
2012 225
2013 262
2014 260
2015 247
2016 288
2017 255
2018 289
2019 281
2020 326
2021 283
2022 312
2023 260
2024 91

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5,846 results

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Page 1
Glutathione in Brain Disorders and Aging.
Iskusnykh IY, Zakharova AA, Pathak D. Iskusnykh IY, et al. Molecules. 2022 Jan 5;27(1):324. doi: 10.3390/molecules27010324. Molecules. 2022. PMID: 35011559 Free PMC article. Review.
However, many metabolic pathways involve oxidization of glutathione, resulting in an imbalance in cellular homeostasis. Impairment of glutathione function in the brain is linked to loss of neurons during the aging process or as the result of neurological dise …
However, many metabolic pathways involve oxidization of glutathione, resulting in an imbalance in cellular homeostasis. Impairment of …
Glutathione is an aging-related metabolic signature in the mouse kidney.
Ahn E, Lee J, Han J, Lee SM, Kwon KS, Hwang GS. Ahn E, et al. Aging (Albany NY). 2021 Sep 7;13(17):21009-21028. doi: 10.18632/aging.203509. Epub 2021 Sep 7. Aging (Albany NY). 2021. PMID: 34492635 Free PMC article.
In transcriptomic analysis, differential expression of metabolic enzymes is consistent with the hypothesis of aging-dependent rewiring in renal glutathione metabolism; pathway and network analyses further revealed the increased expression of immune-related genes in …
In transcriptomic analysis, differential expression of metabolic enzymes is consistent with the hypothesis of aging-dependent rewirin …
Dietary thiols accelerate aging of C. elegans.
Gusarov I, Shamovsky I, Pani B, Gautier L, Eremina S, Katkova-Zhukotskaya O, Mironov A, Makarov AА, Nudler E. Gusarov I, et al. Nat Commun. 2021 Jul 15;12(1):4336. doi: 10.1038/s41467-021-24634-3. Nat Commun. 2021. PMID: 34267196 Free PMC article.
Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging and age-related diseases, and antioxidants can neutralize ROS, it follows that GSH and its precursor, N-acetyl cysteine (NAC), are amon …
Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging …
Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis.
Zhu S, Makosa D, Miller B, Griffin TM. Zhu S, et al. Connect Tissue Res. 2020 Jan;61(1):34-47. doi: 10.1080/03008207.2019.1665035. Epub 2019 Sep 15. Connect Tissue Res. 2020. PMID: 31522568 Free PMC article. Review.
The purpose of this article was to review and experimentally evaluate oxidative stress resistance and resilience concepts in cartilage using glutathione redox homeostasis as an example. This framework may help identify novel approaches for promoting chondrocyte homeostasis …
The purpose of this article was to review and experimentally evaluate oxidative stress resistance and resilience concepts in cartilage using …
Effect of aging on glutathione metabolism. Protection by antioxidants.
Viña J, Sastre J, Anton V, Bruseghini L, Esteras A, Asensi M. Viña J, et al. EXS. 1992;62:136-44. doi: 10.1007/978-3-0348-7460-1_14. EXS. 1992. PMID: 1450581 Review.
Thus, changes in antioxidant mechanisms may occur with aging. Since glutathione is one of the most effective antioxidant systems in the cell, its metabolism may change with aging. In this chapter we describe experiments which show the involvement of glutat …
Thus, changes in antioxidant mechanisms may occur with aging. Since glutathione is one of the most effective antioxidant syste …
The effects of stress and aging on glutathione metabolism.
Maher P. Maher P. Ageing Res Rev. 2005 May;4(2):288-314. doi: 10.1016/j.arr.2005.02.005. Ageing Res Rev. 2005. PMID: 15936251 Review.
However, mild stress generally increases glutathione levels, often but not exclusively through effects on glutamate cysteine ligase, the rate-limiting enzyme for glutathione biosynthesis. ...In contrast, during aging, glutathione levels appear to decli …
However, mild stress generally increases glutathione levels, often but not exclusively through effects on glutamate cysteine ligase, …
Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.
Homma T, Fujii J. Homma T, et al. Curr Drug Metab. 2015;16(7):560-71. doi: 10.2174/1389200216666151015114515. Curr Drug Metab. 2015. PMID: 26467067 Review.
Glutathione (GSH), an abundant tripeptidyl molecule, plays pivotal roles in protecting cells against oxidative stress-induced cellular damage and in detoxifying xenobiotics and drug metabolism. ...Decreased GSH levels are associated with the common features of aging …
Glutathione (GSH), an abundant tripeptidyl molecule, plays pivotal roles in protecting cells against oxidative stress-induced cellula …
Pro-oxidant shift in glutathione redox state during aging.
Rebrin I, Sohal RS. Rebrin I, et al. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1545-52. doi: 10.1016/j.addr.2008.06.001. Epub 2008 Jul 4. Adv Drug Deliv Rev. 2008. PMID: 18652861 Free PMC article. Review.
The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the aging process due to an elevation in the GSSG content and a decline in the ability for de novo GSH biosynthesis. ...Over-expression of GCL …
The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the agi …
Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.
Someya S, Kim MJ. Someya S, et al. Hear Res. 2021 Mar 15;402:108002. doi: 10.1016/j.heares.2020.108002. Epub 2020 May 28. Hear Res. 2021. PMID: 32600853 Free PMC article. Review.
AHL is thought to be a multifactorial condition resulting from the interaction of numerous causes including aging, genetics, exposure to noise, and exposure to endogenous and exogenous toxins. ...The cellular detoxification system involves three phases of enzymatic detoxif …
AHL is thought to be a multifactorial condition resulting from the interaction of numerous causes including aging, genetics, exposure …
5,846 results