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163 results

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Page 1
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. Nagasaki T, et al. J Clin Invest. 2022 Jan 4;132(1):e151685. doi: 10.1172/JCI151685. J Clin Invest. 2022. PMID: 34762602 Free PMC article.
When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine-binding protein 1 (PEBP1), hydroperoxy-phospholipids, which drive ferroptotic cell death, are generated. Peroxidases, inc …
When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosph …
CFTR Protein: Not Just a Chloride Channel?
Hanssens LS, Duchateau J, Casimir GJ. Hanssens LS, et al. Cells. 2021 Oct 22;10(11):2844. doi: 10.3390/cells10112844. Cells. 2021. PMID: 34831067 Free PMC article. Review.
Yet, the CFTR protein also regulates numerous other pathways, such as the transport of HCO(3)(-), glutathione and thiocyanate, immune cells, and the metabolism of lipids. It influences the pH homeostasis of airway surface liquid and thus the MCC as well as innate im …
Yet, the CFTR protein also regulates numerous other pathways, such as the transport of HCO(3)(-), glutathione and thiocyanate, immune …
LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling.
Garcia-Arcos I, Park SS, Mai M, Alvarez-Buve R, Chow L, Cai H, Baumlin-Schmid N, Agudelo CW, Martinez J, Kim MD, Dabo AJ, Salathe M, Goldberg IJ, Foronjy RF. Garcia-Arcos I, et al. J Lipid Res. 2022 Apr;63(4):100185. doi: 10.1016/j.jlr.2022.100185. Epub 2022 Feb 21. J Lipid Res. 2022. PMID: 35202607 Free PMC article.
We found that bronchial epithelium of patients with chronic obstructive pulmonary disease and airway epithelium of mice exposed to smoke had increased LRP1 expression. ...Proteomic analysis of room air exposed-club Lrp1(-/-) mice showed significantly decrease …
We found that bronchial epithelium of patients with chronic obstructive pulmonary disease and airway epithelium of mice …
Glutathione S-transferase M1 modulates allergen-induced NF-kappaB activation in asthmatic airway epithelium.
Polosukhin VV, Polosukhin IV, Hoskins A, Han W, Abdolrasulnia R, Blackwell TS, Dworski R. Polosukhin VV, et al. Allergy. 2014 Dec;69(12):1666-72. doi: 10.1111/all.12506. Epub 2014 Oct 1. Allergy. 2014. PMID: 25118837 Free PMC article.
BACKGROUND: Glutathione S-transferase M1 (GSTM1) is a phase II enzyme and regulator of inflammatory signaling in airway epithelial cells. ...A quantitative analysis of NF-kappaB activation in airway epithelium was accomplished using a polyclonal antibo …
BACKGROUND: Glutathione S-transferase M1 (GSTM1) is a phase II enzyme and regulator of inflammatory signaling in airway epithe …
Extracellular oxidation in cystic fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity.
Stolarczyk M, Veit G, Schnúr A, Veltman M, Lukacs GL, Scholte BJ. Stolarczyk M, et al. Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L555-L568. doi: 10.1152/ajplung.00458.2017. Epub 2017 Dec 14. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29351448 Free article.
Compared with iCFTR(+) cells, iCFTR(-) cells displayed enhanced apical presentation and phosphorylation of EGFR, in accordance with enhanced EGFR/ADAM17 activity in CFTR-deficient cells. The nonpermeant natural antioxidant glutathione (GSH) strongly inhibited AREG release …
Compared with iCFTR(+) cells, iCFTR(-) cells displayed enhanced apical presentation and phosphorylation of EGFR, in accordance with enhanced …
Glutathione S-transferases in tracheobronchial epithelium.
Reddy PM, Tu CP, Wu R. Reddy PM, et al. Am J Physiol. 1995 Oct;269(4 Pt 1):L473-81. doi: 10.1152/ajplung.1995.269.4.L473. Am J Physiol. 1995. PMID: 7485519
The purpose of this study is to characterize glutathione S-transferase (GST) gene expression in airway epithelium both in vivo and in vitro. Immunohistochemical staining of nonhuman primate lungs of well-controlled healthy animals reveals the presence of alph …
The purpose of this study is to characterize glutathione S-transferase (GST) gene expression in airway epithelium both …
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype.
Deeb RS, Walters MS, Strulovici-Barel Y, Chen Q, Gross SS, Crystal RG. Deeb RS, et al. Am J Respir Cell Mol Biol. 2016 Feb;54(2):231-40. doi: 10.1165/rcmb.2015-0055OC. Am J Respir Cell Mol Biol. 2016. PMID: 26161876 Free PMC article.
The major cell types of the airway epithelium include basal, intermediate columnar, ciliated, and secretory. Basal cells (BCs) are the proliferating stem/progenitor population that differentiate into the other specialized cell types of the airway epitheliu …
The major cell types of the airway epithelium include basal, intermediate columnar, ciliated, and secretory. Basal cells (BCs) …
Mechanisms and modification of chlorine-induced lung injury in animals.
Yadav AK, Bracher A, Doran SF, Leustik M, Squadrito GL, Postlethwait EM, Matalon S. Yadav AK, et al. Proc Am Thorac Soc. 2010 Jul;7(4):278-83. doi: 10.1513/pats.201001-009SM. Proc Am Thorac Soc. 2010. PMID: 20601632 Free PMC article. Review.
Exposure of both humans and animals to high concentrations of Cl(2) results in acute lung injury, which may resolve spontaneously or progress to acute respiratory failure. Injury to airway and alveolar epithelium may result from chemical reactions of Cl(2), from HOC …
Exposure of both humans and animals to high concentrations of Cl(2) results in acute lung injury, which may resolve spontaneously or progres …
TBC1D23-AAVR Interaction Drives Endosome-to-TGN Trafficking Required for rAAV Transduction.
Zhang X, Habib A, McFarlin S, Richart D, Park SY, Cheng F, Wang J, Yan Z, Qiu J. Zhang X, et al. bioRxiv [Preprint]. 2026 Jun 3:2026.06.02.729721. doi: 10.64898/2026.06.02.729721. bioRxiv. 2026. PMID: 42282593 Free PMC article. Preprint.
CRISPR-mediated knockout of TBC1D23 severely impairs rAAV transduction across multiple human cell types, including polarized human airway epithelium (HAE). Loss of TBC1D23 disrupts convergence of internalized AAV capsids at the TGN, leading to diminished nuclear imp …
CRISPR-mediated knockout of TBC1D23 severely impairs rAAV transduction across multiple human cell types, including polarized human airway …
Oxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD.
Yang JJ, Liu HJ, Wang YX, Wang LP, Gu JJ, Gao JY, Ren KQ, Min LF. Yang JJ, et al. Lung. 2025 Feb 25;203(1):36. doi: 10.1007/s00408-025-00790-x. Lung. 2025. PMID: 40000498
PURPOSE: Cigarette smoke (CS) has been demonstrated to mediate oxidative stress (OS) and epithelial-mesenchymal transition (EMT) in bronchial epithelial cells, thereby contributing to airway remodeling in chronic obstructive pulmonary disease (COPD). Studies have shown upr …
PURPOSE: Cigarette smoke (CS) has been demonstrated to mediate oxidative stress (OS) and epithelial-mesenchymal transition (EMT) in bronchia …
163 results