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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1977 1
1979 1
1980 1
1981 1
1982 3
1984 8
1985 4
1986 1
1987 4
1988 4
1989 3
1990 1
1991 10
1992 6
1993 14
1994 9
1995 7
1996 13
1997 16
1998 20
1999 16
2000 13
2001 24
2002 27
2003 22
2004 20
2005 36
2006 26
2007 36
2008 36
2009 48
2010 38
2011 41
2012 41
2013 40
2014 39
2015 36
2016 57
2017 47
2018 54
2019 46
2020 47
2021 49
2022 49
2023 47
2024 42
2025 57
2026 17

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1,045 results

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Page 1
Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity.
Xu Y, Jones BE, Neufeld DS, Czaja MJ. Xu Y, et al. Gastroenterology. 1998 Nov;115(5):1229-37. doi: 10.1016/s0016-5085(98)70095-2. Gastroenterology. 1998. PMID: 9797379
METHODS: A rat hepatocyte cell line and primary hepatocytes sensitized to TNF-alpha toxicity by the addition of actinomycin D were examined for changes in glutathione levels and for the effects of glutathione depletion or supplementation on cell death. …
METHODS: A rat hepatocyte cell line and primary hepatocytes sensitized to TNF-alpha toxicity by the addition of actinomycin D …
Non-Alcoholic Fatty Liver Disease.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:443-467. doi: 10.1007/978-3-319-48382-5_19. Adv Exp Med Biol. 2017. PMID: 28585211 Free article. Review.
NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. ...Activities of mitochondrial respiratory chain complexes are decreased in liver tissue of patients with NASH. …
NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and …
Bile-acid-induced cell injury and protection.
Perez MJ, Briz O. Perez MJ, et al. World J Gastroenterol. 2009 Apr 14;15(14):1677-89. doi: 10.3748/wjg.15.1677. World J Gastroenterol. 2009. PMID: 19360911 Free PMC article. Review.
BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. …
BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species …
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.
Szkolnicka D, Lucendo-Villarin B, Moore JK, Simpson KJ, Forbes SJ, Hay DC. Szkolnicka D, et al. Stem Cells Transl Med. 2016 Jun;5(6):764-72. doi: 10.5966/sctm.2015-0117. Epub 2016 Apr 7. Stem Cells Transl Med. 2016. PMID: 27057006 Free PMC article.
Our study centers on the major metabolic cell type of the liver, the hepatocyte, and its susceptibility to damage during drug overdose. In these studies, hepatocytes were generated from a renewable and genetically defined resource. ...The major metabolic cell type o …
Our study centers on the major metabolic cell type of the liver, the hepatocyte, and its susceptibility to damage during drug overdos …
Keap1 Deletion Rescues Cell Death Associated With Gpx4 Loss in Hepatocytes During Acute Liver Injury.
Colyn L, Grube J, Wang C, Dietrich J, Kühnel M, Reinders J, Edlund K, Jonigk D, Gaßler N, Hengstler J, Trautwein C. Colyn L, et al. Liver Int. 2025 Sep;45(9):e70210. doi: 10.1111/liv.70210. Liver Int. 2025. PMID: 40844245 Free PMC article.
The extensive loss of liver function results from severe hepatocyte death, where elevated reactive oxygen species (ROS) play a significant role. Nuclear factor erythroid-2 like 2 (Nrf2) is crucial in ROS defence by regulating genes like glutathione peroxidase 4 (GPX …
The extensive loss of liver function results from severe hepatocyte death, where elevated reactive oxygen species (ROS) play a signif …
Injinoryeong-San attenuates metabolic dysfunction-associated steatohepatitis via regulation of YAP/TAZ-signaling pathway.
Seo HS, Kim HG, Joo H, Kwon J, Cho JH. Seo HS, et al. J Ethnopharmacol. 2025 Sep 25;353(Pt A):120292. doi: 10.1016/j.jep.2025.120292. Epub 2025 Jul 17. J Ethnopharmacol. 2025. PMID: 40683423

However, IJO significantly decreased these markers by recovering total glutathione, superoxide dismutase activities, and catalase activities (P < 0.05 to 0.001). IJO remarkably decreased pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin

…
However, IJO significantly decreased these markers by recovering total glutathione, superoxide dismutase activities, and catalase act …
Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis.
Gumpricht E, Devereaux MW, Dahl RH, Sokol RJ. Gumpricht E, et al. Toxicol Appl Pharmacol. 2000 Apr 1;164(1):102-11. doi: 10.1006/taap.2000.8894. Toxicol Appl Pharmacol. 2000. PMID: 10739750
Higher concentrations of GCDC (>/=500 microM) favored cellular necrosis and lipid peroxidation. Depleting GSH by treating hepatocytes with 1-bromoheptane increased their sensitivity toward GCDC-induced cellular necrosis, but not apoptosis. However, enhanci …
Higher concentrations of GCDC (>/=500 microM) favored cellular necrosis and lipid peroxidation. Depleting GSH by treating hepat …
Formaldehyde and hepatotoxicity: a review.
Beall JR, Ulsamer AG. Beall JR, et al. J Toxicol Environ Health. 1984;14(1):1-21. doi: 10.1080/15287398409530560. J Toxicol Environ Health. 1984. PMID: 6389892 Review.
Depending on the route of exposure could include direct effects on hepatocytes and/or indirect effects through the circulatory and immune systems. The catabolism of formaldehyde includes conversion to CO2 by reactions involving glutathione. Many hepatotoxic chemical …
Depending on the route of exposure could include direct effects on hepatocytes and/or indirect effects through the circulatory and im …
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.
Nagai H, Matsumaru K, Feng G, Kaplowitz N. Nagai H, et al. Hepatology. 2002 Jul;36(1):55-64. doi: 10.1053/jhep.2002.33995. Hepatology. 2002. PMID: 12085349
The effect of reduced glutathione (GSH) depletion by acetaminophen (APAP), diethylmaleate (DEM), or phorone on the mode of cell death and susceptibility to tumor necrosis factor (TNF)-induced cell death was studied in cultured mouse hepatocytes. ...GSH monoet …
The effect of reduced glutathione (GSH) depletion by acetaminophen (APAP), diethylmaleate (DEM), or phorone on the mode of cell death …
Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c.
Ghoneim AI. Ghoneim AI. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):47-60. doi: 10.1007/s00210-008-0335-2. Epub 2008 Aug 21. Naunyn Schmiedebergs Arch Pharmacol. 2009. PMID: 18716759
Ethanol-induced hepatocyte necrosis and apoptosis are valid in vitro models to investigate the modulatory effects of hepatoprotective/toxic agents such as curcumin. In this study, suspension and monolayer cultures of isolated rat hepatocytes were used. Levels …
Ethanol-induced hepatocyte necrosis and apoptosis are valid in vitro models to investigate the modulatory effects of hepatopro …
1,045 results