Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1974 1
1975 3
1976 3
1977 5
1978 15
1979 12
1980 19
1981 23
1982 42
1983 47
1984 73
1985 59
1986 62
1987 84
1988 96
1989 85
1990 96
1991 151
1992 117
1993 128
1994 134
1995 116
1996 150
1997 143
1998 117
1999 130
2000 121
2001 133
2002 134
2003 107
2004 132
2005 138
2006 169
2007 180
2008 187
2009 169
2010 200
2011 191
2012 220
2013 227
2014 204
2015 218
2016 234
2017 256
2018 207
2019 221
2020 204
2021 219
2022 193
2023 196
2024 234
2025 286
2026 149

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

6,352 results

Results by year

Filters applied: . Clear all
Page 1
Multi-zonal liver organoids from human pluripotent stem cells.
Reza HA, Santangelo C, Iwasawa K, Reza AA, Sekiya S, Glaser K, Bondoc A, Merola J, Takebe T. Reza HA, et al. Nature. 2025 May;641(8065):1258-1267. doi: 10.1038/s41586-025-08850-1. Epub 2025 Apr 16. Nature. 2025. PMID: 40240593 Free PMC article.
Distinct hepatocyte subpopulations are spatially segregated along the portal-central axis and are critical to understanding metabolic homeostasis and injury in the liver(1). ...We found that preconditioned hepatocyte-like cells exhibited zone-specific functio …
Distinct hepatocyte subpopulations are spatially segregated along the portal-central axis and are critical to understanding metabolic …
Taohong Siwu Decoction modulates glutathione metabolism to suppress hepatocyte ferroptosis and demonstrates anti-fibrotic effects in the liver.
Xiao Z, Gao S, Li S, Yang F, Zhang D, Niu Z, Zhang Y, Duan Z, Qi S, Ma S. Xiao Z, et al. J Ethnopharmacol. 2025 Jun 26;350:120025. doi: 10.1016/j.jep.2025.120025. Epub 2025 May 23. J Ethnopharmacol. 2025. PMID: 40414577
Additionally, the 4D Label-free quantitative proteomic analysis of liver samples was applied. In vitro, erastin-induced BRL-3A cells, a rat hepatocyte line, were performed as a hepatocyte ferroptosis model and treated with or without drug-containing serum of …
Additionally, the 4D Label-free quantitative proteomic analysis of liver samples was applied. In vitro, erastin-induced BRL-3A cells, …
Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury.
Kotulkar M, Paine-Cabrera D, Abernathy S, Robarts DR, Parkes WS, Lin-Rahardja K, Numata S, Lebofsky M, Jaeschke H, Apte U. Kotulkar M, et al. Hepatology. 2023 Oct 1;78(4):1106-1117. doi: 10.1097/HEP.0000000000000367. Epub 2023 Apr 7. Hepatology. 2023. PMID: 37021787 Free PMC article.
BACKGROUND AND AIMS: Overdose of acetaminophen (APAP) is the major cause of acute liver failure in the western world. We report a novel signaling interaction between hepatocyte nuclear factor 4 alpha (HNF4alpha) cMyc and nuclear factor erythroid 2-related factor 2 ( …
BACKGROUND AND AIMS: Overdose of acetaminophen (APAP) is the major cause of acute liver failure in the western world. We report a nov …
Glutathione-mediated biotransformation in the liver modulates nanoparticle transport.
Jiang X, Du B, Zheng J. Jiang X, et al. Nat Nanotechnol. 2019 Sep;14(9):874-882. doi: 10.1038/s41565-019-0499-6. Epub 2019 Jul 15. Nat Nanotechnol. 2019. PMID: 31308501 Free PMC article.
Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though bo …
Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but …
Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice.
Gong S, Zeng Y, Wang Z, Li Y, Wu R, Li L, Hu H, Qin P, Yu Z, Huang X, Guo P, Yang H, He Y, Zhao Z, Xiao W, Zhao X, Gao L, Cai S, Zeng Z. Gong S, et al. Gut Microbes. 2024 Jan-Dec;16(1):2404138. doi: 10.1080/19490976.2024.2404138. Epub 2024 Sep 21. Gut Microbes. 2024. PMID: 39305468 Free PMC article.
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. ...Administration of deguelin was capable of alleviating hepatotoxic …
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibil …
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.
Prigge JR, Eriksson S, Iverson SV, Meade TA, Capecchi MR, Arnér ES, Schmidt EE. Prigge JR, et al. Free Radic Biol Med. 2012 Feb 15;52(4):803-10. doi: 10.1016/j.freeradbiomed.2011.11.025. Epub 2011 Dec 8. Free Radic Biol Med. 2012. PMID: 22198266 Free PMC article.
To better understand the in vivo electron donor requirements for mammalian RNR, we here investigated whether replication of TrxR1-deficient hepatocytes in mouse livers either employed an alternative source of Trx-reducing activity or, instead, solely relied upon the …
To better understand the in vivo electron donor requirements for mammalian RNR, we here investigated whether replication of TrxR1-deficient …
Kidney ischemia/reperfusion injury causes cholangiocytes primary cilia disruption and abnormal bile secretion.
Han YK, Lim HJ, Jang G, Jang SY, Park KM. Han YK, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Aug;1870(6):167225. doi: 10.1016/j.bbadis.2024.167225. Epub 2024 May 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38749218 Free article.
Glutathione (GSH) and H(2)S levels in the livers were significantly reduced by KIR, resulting in increased the ratio oxidized GSH to total GSH, and oxidation of tissue and bile. CSE and cystathione beta-synthase (CBS) expression were lowered in the liver afte …
Glutathione (GSH) and H(2)S levels in the livers were significantly reduced by KIR, resulting in increased the ratio oxidized …
Glutathione defense mechanism in liver injury: insights from animal models.
Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Chen Y, et al. Food Chem Toxicol. 2013 Oct;60:38-44. doi: 10.1016/j.fct.2013.07.008. Epub 2013 Jul 12. Food Chem Toxicol. 2013. PMID: 23856494 Free PMC article. Review.
Glutathione (GSH) is the most abundant cellular thiol antioxidant and it exhibits numerous and versatile functions. ...In particular, mice engineered to not express the catalytic subunit of GCL in hepatocytes [Gclc(h/h) mice] experience almostcomplete loss of hepati …
Glutathione (GSH) is the most abundant cellular thiol antioxidant and it exhibits numerous and versatile functions. ...In particular, …
Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury.
Wang H, Wang Q, Yang C, Guo M, Cui X, Jing Z, Liu Y, Qiao W, Qi H, Zhang H, Zhang X, Zhao N, Zhang M, Chen M, Zhang S, Xu H, Zhao L, Qiao M, Wu Z. Wang H, et al. Gut Microbes. 2022 Jan-Dec;14(1):2027853. doi: 10.1080/19490976.2022.2027853. Gut Microbes. 2022. PMID: 35129072 Free PMC article.
Only BA played a protective role against ConA-induced liver injury. Further studies demonstrated that BA-reconstituted mice had reduced CD95/CD95L signaling, which was required for the decrease in the L-glutathione/glutathione (GSSG/GSH) ratio observed in the …
Only BA played a protective role against ConA-induced liver injury. Further studies demonstrated that BA-reconstituted mice had reduc …
Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated H(2)S-albumin thiol antioxidant network.
Wang X, Sui Y, Jiang R, Xu Y, Suda M, Cheng J, Zhang Y, Shi Z, Fan J, Yao J. Wang X, et al. Redox Biol. 2025 Sep;85:103774. doi: 10.1016/j.redox.2025.103774. Epub 2025 Jul 17. Redox Biol. 2025. PMID: 40694957 Free PMC article.
Acetaminophen (APAP) overdose is the leading cause of acute liver failure and a major global health issue. APAP hepatotoxicity is primarily driven by oxidative stress resulting from the depletion of hepatic glutathione (GSH). ...Conversely, supplementation with a mo …
Acetaminophen (APAP) overdose is the leading cause of acute liver failure and a major global health issue. APAP hepatotoxicity is pri …
6,352 results