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418 results

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Page 1
Antioxidant supplementation for lung disease in cystic fibrosis.
Ciofu O, Smith S, Lykkesfeldt J. Ciofu O, et al. Cochrane Database Syst Rev. 2019 Oct 3;10(10):CD007020. doi: 10.1002/14651858.CD007020.pub4. Cochrane Database Syst Rev. 2019. PMID: 31580490 Free PMC article. Review.
Glutathione or NAC can also be inhaled and if administered in this way can also have a mucolytic effect besides the antioxidant effect. Current literature suggests a relationship between oxidative status and lung function. This is an update of a previously pu …
Glutathione or NAC can also be inhaled and if administered in this way can also have a mucolytic effect besides the antioxidant …
DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.
Zeng Z, Li T, Liu X, Ma Y, Luo L, Wang Z, Zhao Z, Li H, He X, Zeng H, Tao Y, Chen Y. Zeng Z, et al. Redox Biol. 2023 Nov;67:102916. doi: 10.1016/j.redox.2023.102916. Epub 2023 Oct 4. Redox Biol. 2023. PMID: 37812881 Free PMC article.
Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality currently. Long-term exposure of cigarette smoke (CS) inducing persistent inflammation, small airway remodeling and emphysematous lung are the distinguishing …
Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality currently. Long-term exposure o …
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.
Rahman I, MacNee W. Rahman I, et al. Am J Physiol. 1999 Dec;277(6):L1067-88. doi: 10.1152/ajplung.1999.277.6.L1067. Am J Physiol. 1999. PMID: 10600876 Review.
Glutathione (GSH), a ubiquitous tripeptide thiol, is a vital intra- and extracellular protective antioxidant in the lungs. ...GSH plays a key role in maintaining oxidant-induced lung epithelial cell function and also in the control of proinflammatory processe …
Glutathione (GSH), a ubiquitous tripeptide thiol, is a vital intra- and extracellular protective antioxidant in the lungs. ... …
Antioxidant supplementation for lung disease in cystic fibrosis.
Ciofu O, Lykkesfeldt J. Ciofu O, et al. Cochrane Database Syst Rev. 2014 Aug 7;(8):CD007020. doi: 10.1002/14651858.CD007020.pub3. Cochrane Database Syst Rev. 2014. PMID: 25102015
Supplementation of antioxidant micronutrients (vitamin E, vitamin C, ss-carotene and selenium) or glutathione may therefore potentially help maintain an oxidant-antioxidant balance. Current literature suggests a relationship between oxidative status and lu …
Supplementation of antioxidant micronutrients (vitamin E, vitamin C, ss-carotene and selenium) or glutathione may therefore po …
Oxidative stress-based therapeutics in COPD.
Barnes PJ. Barnes PJ. Redox Biol. 2020 Jun;33:101544. doi: 10.1016/j.redox.2020.101544. Epub 2020 Apr 20. Redox Biol. 2020. PMID: 32336666 Free PMC article. Review.
There is increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in cigarette smoke and air pollution and due to endogenous generation of reactive oxygen species by inflammatory and structural cells in the lung. Mitochondrial oxidative stress may …
There is increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in cigarette smoke and air pollution and due to …
Antioxidant micronutrients for lung disease in cystic fibrosis.
Shamseer L, Adams D, Brown N, Johnson JA, Vohra S. Shamseer L, et al. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD007020. doi: 10.1002/14651858.CD007020.pub2. Cochrane Database Syst Rev. 2010. Update in: Cochrane Database Syst Rev. 2014 Aug 07;(8):CD007020. doi: 10.1002/14651858.CD007020.pub3. PMID: 21154377 Updated.
Supplementation of antioxidant micronutrients (vitamin E, vitamin C, ss-carotene and selenium) may help maintain an oxidant-antioxidant balance. Current literature suggests a relationship between oxidative status and lung function. OBJECTIVES: To synthesize e …
Supplementation of antioxidant micronutrients (vitamin E, vitamin C, ss-carotene and selenium) may help maintain an oxidant-antiox …
alpha-Tocopherol ameliorates allergic airway inflammation by regulating ILC2 ferroptosis in an LKB1-dependent manner.
Zhang X, Liu J, Chen Z, Zhou S, Wang T, Yang R, Zhu Z, Qiu Q, Guo Y, He Y. Zhang X, et al. Mol Ther. 2025 Dec 3;33(12):6518-6536. doi: 10.1016/j.ymthe.2025.08.053. Epub 2025 Sep 1. Mol Ther. 2025. PMID: 40898617
Mice lacking LKB1 or treated with a SCARB1 antagonist demonstrate a significant reduction in ILC2 abundance, impaired ILC2 functionality, and diminished lung inflammation. Importantly, alpha-Toc fails to alleviate allergic airway inflammation in LKB1-deficient mice. …
Mice lacking LKB1 or treated with a SCARB1 antagonist demonstrate a significant reduction in ILC2 abundance, impaired ILC2 functionality, an …
Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency.
Dickerhof N, Pearson JF, Hoskin TS, Berry LJ, Turner R, Sly PD, Kettle AJ; AREST CF. Dickerhof N, et al. Free Radic Biol Med. 2017 Dec;113:236-243. doi: 10.1016/j.freeradbiomed.2017.09.028. Epub 2017 Oct 2. Free Radic Biol Med. 2017. PMID: 28982600
Neutrophil-derived myeloperoxidase (MPO) is recognized as a major source of oxidative stress at the airway surface of a cystic fibrosis (CF) lung where, despite limited evidence, the antioxidant glutathione is widely considered to be low. ...In non-CF …
Neutrophil-derived myeloperoxidase (MPO) is recognized as a major source of oxidative stress at the airway surface of a cystic fibros …
Sea buckthorn extract mitigates chronic obstructive pulmonary disease by suppression of ferroptosis via scavenging ROS and blocking p53/MAPK pathways.
Liu L, Wen T, Xiao Y, Chen H, Yang S, Shen X. Liu L, et al. J Ethnopharmacol. 2025 Jan 10;336:118726. doi: 10.1016/j.jep.2024.118726. Epub 2024 Aug 23. J Ethnopharmacol. 2025. PMID: 39181279
ETHNOPHARMACOLOGICAL RELEVANCE: Sea buckthorn (Hippophae rhamnoides), a traditional Tibetan medicinal herb, exhibits protective effects against cardiovascular and respiratory diseases. Although Sea buckthorn extract (SBE) has been confirmed to alleviate airway infla …
ETHNOPHARMACOLOGICAL RELEVANCE: Sea buckthorn (Hippophae rhamnoides), a traditional Tibetan medicinal herb, exhibits protective effects agai …
Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation.
Wientjens C, Doverman M, Zurkovic J, More T, Surendar J, Nesic S, Sarici C, Utecht TD, Pohl J, Pollock J, Voehringer D, Hiller K, Thiele C, Wilhelm C. Wientjens C, et al. Immunity. 2026 Feb 10;59(2):322-338.e9. doi: 10.1016/j.immuni.2025.11.018. Epub 2025 Dec 10. Immunity. 2026. PMID: 41380684 Free article.
Cystine acquisition fuels glutathione (GSH) synthesis, which, together with increased expression of glutathione peroxidase 4 (GPX4) and thioredoxin reductase 1 (TXNRD1), confers resistance to ferroptosis by counteracting lipid peroxidation and reactive oxygen specie …
Cystine acquisition fuels glutathione (GSH) synthesis, which, together with increased expression of glutathione peroxidase 4 ( …
418 results