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16,122 results

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Page 1
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K. Wang Y, et al. Nature. 2021 Nov;599(7883):136-140. doi: 10.1038/s41586-021-04025-w. Epub 2021 Oct 27. Nature. 2021. PMID: 34707288 Free PMC article.
Mitochondria, as the major site of oxidative reactions, must maintain sufficient levels of GSH to perform protective and biosynthetic functions(2). GSH is synthesized exclusively in the cytosol, yet the molecular machinery involved in mitochondrial GSH import …
Mitochondria, as the major site of oxidative reactions, must maintain sufficient levels of GSH to perform protective and biosynthetic …
Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC.
Ward NP, Yoon SJ, Flynn T, Sherwood AM, Olley MA, Madej J, DeNicola GM. Ward NP, et al. Nat Commun. 2024 May 18;15(1):4244. doi: 10.1038/s41467-024-48695-2. Nat Commun. 2024. PMID: 38762605 Free PMC article.
Here, we show that despite the rapid depletion of intracellular cysteine upon loss of extracellular cystine, cysteine-dependent synthesis of Fe-S clusters persists in the mitochondria of lung cancer cells. This promotes a retention of respiratory function and a main …
Here, we show that despite the rapid depletion of intracellular cysteine upon loss of extracellular cystine, cysteine-dependent synthesis of …
Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation.
Chen TH, Wang HC, Chang CJ, Lee SY. Chen TH, et al. Int J Mol Sci. 2024 Jan 21;25(2):1314. doi: 10.3390/ijms25021314. Int J Mol Sci. 2024. PMID: 38279310 Free PMC article. Review.
Mitochondria also regulate cell proliferation, metastasis, and deterioration. The flow of electrons in the mitochondrial respiratory chain generates reactive oxygen species (ROS), which are harmful to cells at high levels. ...Mitochondrial glutathione …
Mitochondria also regulate cell proliferation, metastasis, and deterioration. The flow of electrons in the mitochondrial respi …
Nexus between mitochondrial function, iron, copper and glutathione in Parkinson's disease.
Liddell JR, White AR. Liddell JR, et al. Neurochem Int. 2018 Jul;117:126-138. doi: 10.1016/j.neuint.2017.05.016. Epub 2017 May 31. Neurochem Int. 2018. PMID: 28577988 Review.
Parkinson's disease is biochemically characterised by mitochondrial dysfunction, accumulation of iron, diminished copper content and depleted glutathione levels in these regions. ...This leads to the conclusion that disruption of mitochondrial function …
Parkinson's disease is biochemically characterised by mitochondrial dysfunction, accumulation of iron, diminished copper content and …
Mitochondrial glutathione.
Kulinsky VI, Kolesnichenko LS. Kulinsky VI, et al. Biochemistry (Mosc). 2007 Jul;72(7):698-701. doi: 10.1134/s0006297907070024. Biochemistry (Mosc). 2007. PMID: 17680760 Review.
Many functions of mitochondrial GSH are significantly different from those of cytosolic GSH. This review considers the peculiarity of functions of mitochondrial GSH and enzymes of its metabolism, especially glutathione peroxidase 4, glutaredoxin …
Many functions of mitochondrial GSH are significantly different from those of cytosolic GSH. This review considers the peculia …
Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease.
Jenner P. Jenner P. Acta Neurol Scand Suppl. 1993;146:6-13. Acta Neurol Scand Suppl. 1993. PMID: 8333254 Review.
Indeed, in postmortem tissues from patients dying with Parkinson's disease there is evidence for inhibition of complex I of the mitochondrial respiratory chain, altered iron metabolism and decreased levels of reduced glutathione. ...This would suggest that alteratio …
Indeed, in postmortem tissues from patients dying with Parkinson's disease there is evidence for inhibition of complex I of the mitochond …
Mitochondrial Glutathione: Regulation and Functions.
Calabrese G, Morgan B, Riemer J. Calabrese G, et al. Antioxid Redox Signal. 2017 Nov 20;27(15):1162-1177. doi: 10.1089/ars.2017.7121. Epub 2017 Jun 30. Antioxid Redox Signal. 2017. PMID: 28558477 Review.
These probes have revealed that the glutathione pools of the mitochondrial matrix and intermembrane space (IMS) are highly reduced, similar to the cytosolic glutathione pool. The glutathione pool of the IMS is in equilibrium with the cytosolic gluta …
These probes have revealed that the glutathione pools of the mitochondrial matrix and intermembrane space (IMS) are highly red …
Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production.
Yin M, Palsson-McDermott EM, Henry ÓC, Ge Z, Toller-Kawahisa JE, Min Y, McGettrick AF, Gordon AL, Heffernan SB, Marrone L, Marzullo BP, Eales KL, Clayton SA, Tennant DA, Porter RK, O'Neill LAJ. Yin M, et al. Sci Rep. 2025 Dec 1;15(1):42939. doi: 10.1038/s41598-025-30333-6. Sci Rep. 2025. PMID: 41326555 Free PMC article.
Mitochondrial glutathione (mtGSH) supports iron-sulfur cluster (ISC) stability in the electron transport chain (ETC). ...Reducing SLC25A40 expression using siRNA destabilized ISC-rich ETC proteins and elevated mitochondrial and cellular reactive oxygen specie …
Mitochondrial glutathione (mtGSH) supports iron-sulfur cluster (ISC) stability in the electron transport chain (ETC). ...Reduc …
Mesenchymal Stem Cell-Derived Mitochondrial Transfer Promotes Tip Cell Phenotype via Glutathione Metabolic Reprogramming in Stroke Mice.
Zhang Q, Huang J, Chen X, Li L, Chen L, Zhou X, Zhao X, Liu M, Zhao W, Yan J, Wang Y, Su Y, Liu Y, Xu S, Zeng W. Zhang Q, et al. ACS Nano. 2025 Jun 10;19(22):20452-20471. doi: 10.1021/acsnano.4c15759. Epub 2025 May 31. ACS Nano. 2025. PMID: 40448640
Here, we designed an Arg-Gly-Asp peptide (RGD)-modified, mitochondria-enriched, and extracellular vesicle mimetics (mitoEVMs) platform for mitochondrial transfer. ...We noticed mitochondrial transfer rescued mitochondrial function in ECs and rep …
Here, we designed an Arg-Gly-Asp peptide (RGD)-modified, mitochondria-enriched, and extracellular vesicle mimetics (mitoEVMs) platfor …
Impairment of brain mitochondrial function by reactive nitrogen species: the role of glutathione in dictating susceptibility.
Heales SJ, Bolaños JP. Heales SJ, et al. Neurochem Int. 2002 May;40(6):469-74. doi: 10.1016/s0197-0186(01)00117-6. Neurochem Int. 2002. PMID: 11850103 Review.
Inhibition of this component may lead to an increase in mitochondrial superoxide formation, exacerbation of cellular oxidative stress and further mitochondrial damage. ...Loss of brain glutathione may therefore be an important factor in those neurological con …
Inhibition of this component may lead to an increase in mitochondrial superoxide formation, exacerbation of cellular oxidative stress …
16,122 results
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