Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1996 1
1997 1
1998 1
2002 4
2004 1
2005 1
2006 3
2007 5
2008 2
2009 2
2010 3
2011 3
2012 6
2013 10
2014 8
2015 10
2016 12
2017 10
2018 18
2019 20
2020 27
2021 30
2022 20
2023 37
2024 27
2025 49
2026 30

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

300 results

Results by year

Filters applied: . Clear all
Page 1
Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction.
Smits MAJ, Schomakers BV, van Weeghel M, Wever EJM, Wüst RCI, Dijk F, Janssens GE, Goddijn M, Mastenbroek S, Houtkooper RH, Hamer G. Smits MAJ, et al. Hum Reprod. 2023 Nov 2;38(11):2208-2220. doi: 10.1093/humrep/dead177. Hum Reprod. 2023. PMID: 37671592 Free PMC article.
STUDY QUESTION: Are human ovarian aging and the age-related female fertility decline caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER: We found oxidative damage in oocytes of advanced maternal age, even at the primordial follicle s …
STUDY QUESTION: Are human ovarian aging and the age-related female fertility decline caused by oxidative stress and mitochondrial dysfunctio …
Polystyrene microplastics induced female reproductive toxicity in mice.
Liu Z, Zhuan Q, Zhang L, Meng L, Fu X, Hou Y. Liu Z, et al. J Hazard Mater. 2022 Feb 15;424(Pt C):127629. doi: 10.1016/j.jhazmat.2021.127629. Epub 2021 Oct 30. J Hazard Mater. 2022. PMID: 34740508 Free article.
The results also showed that PS-MPs exposure decreased the first polar body extrusion rate and the survival rate of superovulated oocytes. Meanwhile, PS-MPs reduced the level of glutathione (GSH), mitochondrial membrane potential (MMP), endoplasmic reticulum calcium …
The results also showed that PS-MPs exposure decreased the first polar body extrusion rate and the survival rate of superovulated oocytes …
Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence.
Richani D, Dunning KR, Thompson JG, Gilchrist RB. Richani D, et al. Hum Reprod Update. 2021 Jan 4;27(1):27-47. doi: 10.1093/humupd/dmaa043. Hum Reprod Update. 2021. PMID: 33020823 Free article. Review.
BACKGROUND: Within the antral follicle, the oocyte is reliant on metabolic support from its surrounding somatic cells. Metabolism plays a critical role in oocyte developmental competence (oocyte quality). ...Advancing our understanding of basic cellula …
BACKGROUND: Within the antral follicle, the oocyte is reliant on metabolic support from its surrounding somatic cells. Metabolism pla …
Ovarian aging-associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte quality.
Hu J, Wang H, Fang J, Jiang R, Kong Y, Zhang T, Yang G, Jin H, Shi S, Song N, Qi L, Huang X, Wu Z, Yao G. Hu J, et al. FASEB J. 2025 Mar 31;39(6):e70469. doi: 10.1096/fj.202401580RR. FASEB J. 2025. PMID: 40100097
In the physiological state, female fertility declines with age, as evidenced by a steady decline in oocyte quantity and quality. Aging of the first organ, the ovary, is accompanied by increased oxidative stress levels in the ovary, causing a decline in the ovarian r …
In the physiological state, female fertility declines with age, as evidenced by a steady decline in oocyte quantity and quality …
Glycine regulates lipid peroxidation promoting porcine oocyte maturation and early embryonic development.
Gao L, Zhang C, Zheng Y, Wu D, Chen X, Lan H, Zheng X, Wu H, Li S. Gao L, et al. J Anim Sci. 2023 Jan 3;101:skac425. doi: 10.1093/jas/skac425. J Anim Sci. 2023. PMID: 36573588 Free PMC article.
Glycine, one of the main components of glutathione (GSH), plays an important role in the protection of porcine oocytes in vitro. ...Production of high-quality gametes is the premise of livestock reproduction and conservation of germplasm resources, especially …
Glycine, one of the main components of glutathione (GSH), plays an important role in the protection of porcine oocytes in vitr …
Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS.
Li X, Lin Y, Cheng X, Yao G, Yao J, Hu S, Zhu Q, Wang Y, Ding Y, Lu Y, Qi J, Zhao H, Bian X, Du Y, Sun K, Vankelecom H, Sun Y. Li X, et al. Hum Reprod Open. 2024 Feb 28;2024(2):hoae013. doi: 10.1093/hropen/hoae013. eCollection 2024. Hum Reprod Open. 2024. PMID: 38550897 Free PMC article.
The DHEA-induced PCOS rat model was treated with the ferroptosis inhibitor, Fer-1, and the oocytes and metaphase II oocytes were counted after ovarian stimulation. Additionally, rats were treated with the ferroptosis inducer, RSL3, to further explore the effect of f …
The DHEA-induced PCOS rat model was treated with the ferroptosis inhibitor, Fer-1, and the oocytes and metaphase II oocytes we …
Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply.
Zhang H, Li C, Wen D, Li R, Lu S, Xu R, Tang Y, Sun Y, Zhao X, Pan M, Ma B. Zhang H, et al. Redox Biol. 2022 Feb;49:102215. doi: 10.1016/j.redox.2021.102215. Epub 2021 Dec 17. Redox Biol. 2022. PMID: 34929573 Free PMC article.
However, aging-mediated dysregulation in communication between the oocytes and granulosa cells affects the oocyte quality. In the present study, we examined the defected germline-soma communication and reduced mRNA levels encoding key structural components of …
However, aging-mediated dysregulation in communication between the oocytes and granulosa cells affects the oocyte quality …
Tryptophan Metabolism as a Key Target in PFOS-Mediated Decline of Porcine Oocyte Quality.
Huang G, Cui Z, Gao Q, An Z, Liu P, Wang H, Miao Y. Huang G, et al. Environ Sci Technol. 2025 Jun 3;59(21):10182-10193. doi: 10.1021/acs.est.5c01550. Epub 2025 May 15. Environ Sci Technol. 2025. PMID: 40372800
In this study, an untargeted metabolomic analysis revealed that PFOS exposure significantly disrupted metabolic homeostasis in oocytes. Using public databases to predict potential target proteins of PFOS and performing KEGG pathway enrichment analysis, we identified the tr …
In this study, an untargeted metabolomic analysis revealed that PFOS exposure significantly disrupted metabolic homeostasis in oocytes …
Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice .
Lim J, Ali S, Liao LS, Nguyen ES, Ortiz L, Reshel S, Luderer U. Lim J, et al. Biol Reprod. 2020 Apr 24;102(5):1065-1079. doi: 10.1093/biolre/ioaa009. Biol Reprod. 2020. PMID: 31950131 Free PMC article.
The tripeptide thiol antioxidant glutathione (GSH) has multiple physiological functions. Female mice lacking the modifier subunit of glutamate cysteine ligase (GCLM), the rate-limiting enzyme in GSH synthesis, have decreased GSH concentrations, ovarian oxidative stress, pr …
The tripeptide thiol antioxidant glutathione (GSH) has multiple physiological functions. Female mice lacking the modifier subunit of …
Dendrobine enhances bovine oocyte maturation and subsequent embryonic development and quality.
Zhao Y, E Z, Jiao A, Sun Z, Zhang H, Wang H, Fang N, Gao Q, Jin Q. Zhao Y, et al. Theriogenology. 2023 Jun;203:53-60. doi: 10.1016/j.theriogenology.2023.03.015. Epub 2023 Mar 21. Theriogenology. 2023. PMID: 36972665
Strategies for improving the quality of oocytes have important theoretical and practical significance for increasing the efficiency of livestock breeding. ...Further, we found that DNE treatment decreased the frequency of spindle/chromosome defects and ROS and incre …
Strategies for improving the quality of oocytes have important theoretical and practical significance for increasing the effic …
300 results