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Year Number of Results
1978 1
1979 1
1980 1
1981 4
1982 3
1983 3
1984 3
1985 8
1986 9
1987 17
1988 15
1989 24
1990 29
1991 38
1992 45
1993 56
1994 83
1995 132
1996 143
1997 175
1998 192
1999 225
2000 277
2001 326
2002 399
2003 451
2004 539
2005 696
2006 771
2007 817
2008 817
2009 915
2010 1088
2011 1228
2012 1381
2013 1447
2014 1521
2015 1531
2016 1530
2017 1534
2018 1537
2019 1609
2020 1832
2021 1784
2022 1793
2023 1523
2024 1683
2025 2063
2026 1046

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28,715 results

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Page 1
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M. Seiler A, et al. Cell Metab. 2008 Sep;8(3):237-48. doi: 10.1016/j.cmet.2008.07.005. Cell Metab. 2008. PMID: 18762024 Free article.
Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative disorders, yet the molecular mechanisms have remained unclear. In contrast to the belief that oxygen radicals are detrimental to cells and t …
Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative …
The role of glutathione peroxidase-1 in health and disease.
Handy DE, Loscalzo J. Handy DE, et al. Free Radic Biol Med. 2022 Aug 1;188:146-161. doi: 10.1016/j.freeradbiomed.2022.06.004. Epub 2022 Jun 9. Free Radic Biol Med. 2022. PMID: 35691509 Free PMC article. Review.
Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it has a single redox-sensitive selenocysteine amino acid that is important for the enzymatic red …
Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of …
Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8.
Yang Y, Peng H, Meng D, Fa Z, Yao C, Lin X, Schick J, Jin X. Yang Y, et al. Biomolecules. 2025 Jun 10;15(6):847. doi: 10.3390/biom15060847. Biomolecules. 2025. PMID: 40563487 Free PMC article. Review.
A key novel component in endoplasmic reticulum stress adaptation is the redox-sensitive enzyme glutathione peroxidase 8 (GPX8), which plays a dual role in detoxifying hydrogen peroxide and supporting proper protein folding. ...Understanding the intricate rela …
A key novel component in endoplasmic reticulum stress adaptation is the redox-sensitive enzyme glutathione peroxidase 8 …
Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses.
Miyamoto Y, Koh YH, Park YS, Fujiwara N, Sakiyama H, Misonou Y, Ookawara T, Suzuki K, Honke K, Taniguchi N. Miyamoto Y, et al. Biol Chem. 2003 Apr;384(4):567-74. doi: 10.1515/BC.2003.064. Biol Chem. 2003. PMID: 12751786 Review.
However, in the last 10-15 years, a considerable body of evidence has accumulated that ROS serve as subcellular messengers, and play a role in gene regulation and signal transduction pathways, which may be involved in defensive mechanisms against oxidative stress. T …
However, in the last 10-15 years, a considerable body of evidence has accumulated that ROS serve as subcellular messengers, and play a role …
Oxidative stress drives divergent evolution of the glutathione peroxidase (GPX) gene family in mammals.
Tian R, Geng Y, Yang Y, Seim I, Yang G. Tian R, et al. Integr Zool. 2021 Sep;16(5):696-711. doi: 10.1111/1749-4877.12521. Epub 2021 Jan 21. Integr Zool. 2021. PMID: 33417299
Mammals such as cetaceans, bats, and highland species can protect themselves from oxidative stress, a disruption in the balance of reactive oxygen species, which results in oxidative injury and cell damage. ...We also reveal evidence of a correlation between …
Mammals such as cetaceans, bats, and highland species can protect themselves from oxidative stress, a disruption in the balanc …
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer.
Rivadeneira DB, Thosar S, Quann K, Gunn WG, Dean VG, Xie B, Parise A, McGovern AC, Spahr K, Lontos K, Barnes RP, Bruchez MP, Opresko PL, Delgoffe GM. Rivadeneira DB, et al. Immunity. 2025 Oct 14;58(10):2524-2540.e5. doi: 10.1016/j.immuni.2025.08.008. Epub 2025 Sep 9. Immunity. 2025. PMID: 40930086 Free PMC article.
The tumor microenvironment (TME) imposes immunologic and metabolic stresses sufficient to deviate immune cell differentiation into dysfunctional states. Oxidative stress originating in the mitochondria can induce DNA damage, most notably telomeres. Here, we show tha …
The tumor microenvironment (TME) imposes immunologic and metabolic stresses sufficient to deviate immune cell differentiation into dysfuncti …
[The function of glutathione/glutathione peroxidase system in the oxidative stress resistance systems of microbial cells].
Fu RY, Chen J, Li Y. Fu RY, et al. Sheng Wu Gong Cheng Xue Bao. 2007 Sep;23(5):770-5. doi: 10.1016/s1872-2075(07)60048-x. Sheng Wu Gong Cheng Xue Bao. 2007. PMID: 18051850 Free article. Review. Chinese.
The physiological roles of the glutathione(GSH)/glutathione peroxidase(GPx) system in protecting microbial cells against oxidative stress were reviewed. In eukaryotic model microbe Saccharomyces cerevisiae,this system is obligatory in maintainin …
The physiological roles of the glutathione(GSH)/glutathione peroxidase(GPx) system in protecting microbial cells agains …
Oxidative stress and bovine liver diseases: role of glutathione peroxidase and glucose 6-phosphate dehydrogenase.
Abd Ellah MR, Okada K, Yasuda J. Abd Ellah MR, et al. Jpn J Vet Res. 2007 Feb;54(4):163-73. Jpn J Vet Res. 2007. PMID: 17405353 Review.
This article summarizes the different types of free radicals, antioxidants and the effect of oxidative stress on the activities of glutathione peroxidase and glucose 6-phosphate dehydrogenase in bovine liver diseases. ...
This article summarizes the different types of free radicals, antioxidants and the effect of oxidative stress on the activitie …
GpoA glutathione peroxidase links oxidative stress response, antibiotic persistence, and virulence in Streptococcus pneumoniae.
Zappia VE, Hernandez-Morfa M, Raya-Plasencia L, Olivero NB, Cortes PR, Echenique J. Zappia VE, et al. Free Radic Biol Med. 2026 Aug 1;251:359-371. doi: 10.1016/j.freeradbiomed.2026.04.142. Epub 2026 Apr 21. Free Radic Biol Med. 2026. PMID: 42025702
Glutathione peroxidases are conserved enzymes found in prokaryotic and eukaryotic organisms that reduce H(2)O(2) to protect cells from oxidative stress damage. ...This study demonstrates that GpoA functions as an efficient antioxidant enzyme integral to the …
Glutathione peroxidases are conserved enzymes found in prokaryotic and eukaryotic organisms that reduce H(2)O(2) to protect cells fro …
Malondialdehyde, Bcl-2, superoxide dismutase and glutathione peroxidase may mediate the association of sonic hedgehog protein and oxidative stress in autism.
Ghanizadeh A. Ghanizadeh A. Neurochem Res. 2012 Apr;37(4):899-901. doi: 10.1007/s11064-011-0667-z. Epub 2011 Dec 6. Neurochem Res. 2012. PMID: 22143957 Review.
Sonic hedgehog signaling and brain-derived neurotrophic factor play a neuro-protective role against oxidative stress in autism. Sonic hedgehog also increases Bcl-2 expression and the activities of superoxide dismutase and glutathione peroxidase. ...The …
Sonic hedgehog signaling and brain-derived neurotrophic factor play a neuro-protective role against oxidative stress in autism …
28,715 results
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