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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 4
1981 1
1982 1
1984 1
1985 1
1986 2
1987 4
1988 7
1989 6
1990 10
1991 5
1992 4
1993 10
1994 11
1995 4
1996 10
1997 7
1998 14
1999 5
2000 9
2001 10
2002 15
2003 19
2004 20
2005 24
2006 22
2007 20
2008 23
2009 24
2010 23
2011 22
2012 23
2013 28
2014 35
2015 33
2016 33
2017 29
2018 39
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2020 42
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2022 32
2023 17
2024 27
2025 29
2026 16

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684 results

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Page 1
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation.
Wu Q, Li W, Zhao J, Sun W, Yang Q, Chen C, Xia P, Zhu J, Zhou Y, Huang G, Yong C, Zheng M, Zhou E, Gao K. Wu Q, et al. Biomed Pharmacother. 2021 May;137:111308. doi: 10.1016/j.biopha.2021.111308. Epub 2021 Feb 5. Biomed Pharmacother. 2021. PMID: 33556877 Free article.
After treatment with or without APG (125, 250, and 500 mg/kg) for two weeks, urine, serum, and tissue samples were collected to evaluate proteinuria, serum albumin, serum creatinine (Scr), blood urea nitrogen (BUN), superoxide dismutase (SOD) activity, malondialdehyde (MDA), g …
After treatment with or without APG (125, 250, and 500 mg/kg) for two weeks, urine, serum, and tissue samples were collected to evaluate pro …
Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis.
Dong XQ, Chu LK, Cao X, Xiong QW, Mao YM, Chen CH, Bi YL, Liu J, Yan XM. Dong XQ, et al. Redox Rep. 2023 Dec;28(1):2152607. doi: 10.1080/13510002.2022.2152607. Redox Rep. 2023. PMID: 36692085 Free PMC article.
Renal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney diseases (CKD). ...Here, we show that cisplatin induces renal tubular c …
Renal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acut …
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1alpha/HO-1 Pathway in db/db Mice.
Feng X, Wang S, Sun Z, Dong H, Yu H, Huang M, Gao X. Feng X, et al. Front Endocrinol (Lausanne). 2021 Feb 18;12:626390. doi: 10.3389/fendo.2021.626390. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33679620 Free PMC article.
Iron content was elevated in db/db mouse renal tubules compared with db/m mouse renal tubules, and was relieved in renal tubules of db/db mice after Ferrostatin-1 treatment. ...CONCLUSIONS: Our study indicated that ferroptosis might enhan …
Iron content was elevated in db/db mouse renal tubules compared with db/m mouse renal tubules, and was relieved …
Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through beta-hydroxybutyrate production.
Tian Y, Zhou C, Yan Q, Li Z, Chen D, Feng B, Song J. Tian Y, et al. Ren Fail. 2025 Dec;47(1):2438857. doi: 10.1080/0886022X.2024.2438857. Epub 2025 Jan 2. Ren Fail. 2025. PMID: 39746795 Free PMC article.
BACKGROUND: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-protective effects in patients with DKD, independe …
BACKGROUND: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protei …
Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice.
Parsanathan R, Jain SK. Parsanathan R, et al. Free Radic Biol Med. 2019 Feb 1;131:376-381. doi: 10.1016/j.freeradbiomed.2018.12.017. Epub 2018 Dec 19. Free Radic Biol Med. 2019. PMID: 30578920
This study reports glutathione deficiency, excess oxidative stress, and altered vitamin D metabolism in the kidney of mice fed a high-fat diet (HFD). ...In vitro, GSH deficiency per se causes excess oxidative damage (protein carbonylation), and signifi …
This study reports glutathione deficiency, excess oxidative stress, and altered vitamin D metabolism in the kidney of m …
Sodium-glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease.
Tsai YC, Huang JC, Yu PS, Kuo MC, Wu LY, Chang WA, Hwang SJ, Hsu YL. Tsai YC, et al. Redox Rep. 2025 Dec;30(1):2528334. doi: 10.1080/13510002.2025.2528334. Epub 2025 Jul 28. Redox Rep. 2025. PMID: 40722167 Free PMC article.
METHODS: This study used bulk RNA sequencing, in vitro and in vivo models, and human kidney samples to explore the molecular mechanisms involved in oxidative stress and ferroptosis in the proximal tubule (PT) of DKD. ...Transcriptome analysis of primary PT ce …
METHODS: This study used bulk RNA sequencing, in vitro and in vivo models, and human kidney samples to explore the molecular mechanis …
Renal membrane transport of glutathione in toxicology and disease.
Lash LH. Lash LH. Vet Pathol. 2011 Mar;48(2):408-19. doi: 10.1177/0300985810375811. Epub 2010 Jul 23. Vet Pathol. 2011. PMID: 20656901 Review.
To illustrate the function of these transporters, carrier-mediated processes for transport of the tripeptide and antioxidant glutathione across the basolateral, brush-border, and mitochondrial inner membranes of the renal proximal tubule are reviewed. Studies …
To illustrate the function of these transporters, carrier-mediated processes for transport of the tripeptide and antioxidant glutathione …
Therapeutic concentrations of calcineurin inhibitors do not deregulate glutathione redox balance in human renal proximal tubule cells.
Ramazani Y, Knops N, Berlingerio SP, Adebayo OC, Lismont C, Kuypers DJ, Levtchenko E, van den Heuvel LP, Fransen M. Ramazani Y, et al. PLoS One. 2021 Apr 30;16(4):e0250996. doi: 10.1371/journal.pone.0250996. eCollection 2021. PLoS One. 2021. PMID: 33930094 Free PMC article.
However, long-term or high exposure to CNI leads to histological and functional renal damage (CNI-associated nephrotoxicity). In the kidney, proximal tubule cells are the only cells that metabolize CNI and these cells are believed to play a central role in th …
However, long-term or high exposure to CNI leads to histological and functional renal damage (CNI-associated nephrotoxicity). In the …
Surgical stress increases renal glutathione content via increased glucocorticoid, and resistance to subsequent oxidative injury in the rat: significant link between endocrine response and cell defense system under the stress.
Ogasawara M, Nomura K, Shibata N, Ujihara M, Kobayashi M, Demura H. Ogasawara M, et al. Endocr J. 1999 Feb;46(1):99-106. doi: 10.1507/endocrj.46.99. Endocr J. 1999. PMID: 10426573 Free article.
Systemic and nonspecific stress response effects on the cellular defense mechanism were studied in the male rat kidney. Two days after laparotomy-induced surgical stress, rats showed increased serum corticosterone and renal cortical reduced glutathione (GSH). …
Systemic and nonspecific stress response effects on the cellular defense mechanism were studied in the male rat kidney. Two days afte …
Multidrug Resistance-Associated Protein 1 Aberration-Incurred Glutathione Efflux Drives Renal Ferroptosis and Acute Kidney Injury-Chronic Kidney Disease Progression.
Zhao J, An H, Zhou S, Tian T, Yao Y, Shi L. Zhao J, et al. J Cell Physiol. 2025 Oct;240(10):e70105. doi: 10.1002/jcp.70105. J Cell Physiol. 2025. PMID: 41139230
The progression of acute kidney injury (AKI) to chronic kidney disease (CKD) represents a unique renal disease scenario, yet its exact mechanisms remain unclear. ...However, the combined use of MK571 and Fer-1 did not show additional kidney protective …
The progression of acute kidney injury (AKI) to chronic kidney disease (CKD) represents a unique renal disease scenario …
684 results