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The role of gluten challenge in the diagnosis of celiac disease: a review.
Popp A, Laurikka P, Czika D, Kurppa K. Popp A, et al. Expert Rev Gastroenterol Hepatol. 2023 Jul-Dec;17(7):691-700. doi: 10.1080/17474124.2023.2219893. Epub 2023 May 30. Expert Rev Gastroenterol Hepatol. 2023. PMID: 37243608 Review.
INTRODUCTION: Duodenal biopsy is the gold standard in the diagnosis of celiac disease, with increasing utilization of serology. A gluten challenge may be required, for example, when dietary gluten reduction precedes appropriate diagnostic evalua …
INTRODUCTION: Duodenal biopsy is the gold standard in the diagnosis of celiac disease, with increasing utilization of serology …
In Vitro Gluten Challenge Test for Celiac Disease Diagnosis.
Khalesi M, Jafari SA, Kiani M, Picarelli A, Borghini R, Sadeghi R, Eghtedar A, Ayatollahi H, Kianifar HR. Khalesi M, et al. J Pediatr Gastroenterol Nutr. 2016 Feb;62(2):276-83. doi: 10.1097/MPG.0000000000000917. J Pediatr Gastroenterol Nutr. 2016. PMID: 26196202 Review.
OBJECTIVES: The in vitro gluten challenge test is an important diagnostic modality in celiac disease (CD), especially in patients who begin treatment with a gluten-free diet before adequate diagnostic workup or in cases with atypical CD. Available lite …
OBJECTIVES: The in vitro gluten challenge test is an important diagnostic modality in celiac disease (CD), especially i …
Celiac Disease Prevention.
Meijer C, Shamir R, Szajewska H, Mearin L. Meijer C, et al. Front Pediatr. 2018 Nov 30;6:368. doi: 10.3389/fped.2018.00368. eCollection 2018. Front Pediatr. 2018. PMID: 30555808 Free PMC article. Review.
Celiac disease (CD) is a common autoimmune disorder induced by ingestion of gluten in genetically susceptible individuals. ...As following a gluten-free diet is a major challenge, tertiary prevention strategies are discussed as well....
Celiac disease (CD) is a common autoimmune disorder induced by ingestion of gluten in genetically susceptible individuals. ... …
Re-challenge Studies in Non-celiac Gluten Sensitivity: A Systematic Review and Meta-Analysis.
Lionetti E, Pulvirenti A, Vallorani M, Catassi G, Verma AK, Gatti S, Catassi C. Lionetti E, et al. Front Physiol. 2017 Sep 5;8:621. doi: 10.3389/fphys.2017.00621. eCollection 2017. Front Physiol. 2017. PMID: 28928668 Free PMC article.
There was a considerable heterogeneity related to different sample size, type, and amount of gluten administered, duration of challenge and different type of placebo. The overall pooled percentage of patients with a diagnosis of NCGS relapsing after a …
There was a considerable heterogeneity related to different sample size, type, and amount of gluten administered, duration of …
The 5 Ws of a gluten challenge for gluten-related disorders.
Bascuñán KA, Roncoroni L, Branchi F, Doneda L, Scricciolo A, Ferretti F, Araya M, Elli L. Bascuñán KA, et al. Nutr Rev. 2018 Feb 1;76(2):79-87. doi: 10.1093/nutrit/nux068. Nutr Rev. 2018. PMID: 29325090 Review.
Conditions related to gluten ingestion include celiac disease (CD), wheat allergy (WA), and nonceliac gluten sensitivity (NCGS). Although mediated by different pathogenic pathways, these 3 conditions share similar clinical manifestations and can present a dif …
Conditions related to gluten ingestion include celiac disease (CD), wheat allergy (WA), and nonceliac gluten sensitivit …
Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial.
Leonard MM, Silvester JA, Leffler D, Fasano A, Kelly CP, Lewis SK, Goldsmith JD, Greenblatt E, Kwok WW, McAuliffe WJ, Galinsky K, Siegelman J, Chow IT, Wagner JA, Sapone A, Smithson G. Leonard MM, et al. Gastroenterology. 2021 Feb;160(3):720-733.e8. doi: 10.1053/j.gastro.2020.10.040. Epub 2020 Oct 29. Gastroenterology. 2021. PMID: 33130104 Free PMC article. Clinical Trial.
BACKGROUND & AIMS: Gluten challenge is used to diagnose celiac disease (CeD) and for clinical research. Sustained gluten exposure reliably induces histologic changes but is burdensome. ...RESULTS: All assessments showed changes with glute …
BACKGROUND & AIMS: Gluten challenge is used to diagnose celiac disease (CeD) and for clinical research. Sust …
Gastrointestinal and Extraintestinal Symptoms Among Subjects With Celiac Disease Undergoing a Dose-Specified Gluten Challenge: A Systematic Review and Meta-Analysis.
Banegas M, Flores-Marin D, Naskar N, Correa TL, Rotman C, Regis S, Simpson A, Chang D, Silvester J, Therrien A. Banegas M, et al. Am J Gastroenterol. 2026 Feb 1;121(2):501-516. doi: 10.14309/ajg.0000000000003506. Epub 2025 Apr 29. Am J Gastroenterol. 2026. PMID: 40298233 Free PMC article.
INTRODUCTION: Celiac disease (CeD) is an immune-mediated enteropathy driven by gluten ingestion. Gluten challenges (GC) are commonly used to evaluate novel therapeutics and CeD mechanisms, but their associated symptom burden has not been well character …
INTRODUCTION: Celiac disease (CeD) is an immune-mediated enteropathy driven by gluten ingestion. Gluten challenges …
Small- bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease.
Lähdeaho ML, Mäki M, Laurila K, Huhtala H, Kaukinen K. Lähdeaho ML, et al. BMC Gastroenterol. 2011 Nov 24;11:129. doi: 10.1186/1471-230X-11-129. BMC Gastroenterol. 2011. PMID: 22115041 Free PMC article.
BACKGROUND: Due to the restrictive nature of a gluten-free diet, celiac patients are looking for alternative therapies. While drug-development programs include gluten challenges, knowledge regarding the duration of gluten challenge …
BACKGROUND: Due to the restrictive nature of a gluten-free diet, celiac patients are looking for alternative therapies. While …
Prevalence of vomiting and nausea and associated factors after chronic and acute gluten exposure in celiac disease.
Ahonen I, Laurikka P, Koskimaa S, Huhtala H, Lindfors K, Kaukinen K, Kurppa K, Kivelä L. Ahonen I, et al. BMC Gastroenterol. 2023 Sep 6;23(1):301. doi: 10.1186/s12876-023-02934-w. BMC Gastroenterol. 2023. PMID: 37674120 Free PMC article. Review.
BACKGROUND: Vomiting and nausea seem to be relatively specific symptoms related to gluten ingestion in treated celiac disease. However, the overall prevalence and associated factors of these symptoms after chronic gluten exposure at celiac disease d …
BACKGROUND: Vomiting and nausea seem to be relatively specific symptoms related to gluten ingestion in treated celiac disease. …
Coeliac disease and noncoeliac wheat or gluten sensitivity.
Rej A, Aziz I, Sanders DS. Rej A, et al. J Intern Med. 2020 Nov;288(5):537-549. doi: 10.1111/joim.13120. Epub 2020 Jun 22. J Intern Med. 2020. PMID: 32573000 Free article. Review.
Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern be …
Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both c …
35 results