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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1970 1
1971 1
1972 2
1973 4
1974 1
1975 3
1976 1
1978 4
1979 3
1980 8
1981 7
1982 4
1983 2
1984 8
1985 10
1986 8
1987 7
1988 15
1989 15
1990 19
1991 19
1992 28
1993 24
1994 18
1995 28
1996 28
1997 17
1998 36
1999 57
2000 41
2001 32
2002 50
2003 42
2004 65
2005 53
2006 52
2007 64
2008 43
2009 65
2010 71
2011 75
2012 114
2013 78
2014 86
2015 120
2016 111
2017 87
2018 69
2019 68
2020 77
2021 97
2022 63
2023 49
2024 82
2025 74
2026 12

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Search Results

1,981 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.
Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV. Kumar P, et al. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):75-89. doi: 10.1093/gerona/glac135. J Gerontol A Biol Sci Med Sci. 2023. PMID: 35975308 Free PMC article. Clinical Trial.
In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-ac …
In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that suppl …
Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX. Abou-Alfa GK, et al. Lancet Oncol. 2020 Jun;21(6):796-807. doi: 10.1016/S1470-2045(20)30157-1. Epub 2020 May 13. Lancet Oncol. 2020. PMID: 32416072 Free PMC article. Clinical Trial.
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Wittemans LBL, Lotta LA, Oliver-Williams C, Stewart ID, Surendran P, Karthikeyan S, Day FR, Koulman A, Imamura F, Zeng L, Erdmann J, Schunkert H, Khaw KT, Griffin JL, Forouhi NG, Scott RA, Wood AM, Burgess S, Howson JMM, Danesh J, Wareham NJ, Butterworth AS, Langenberg C. Wittemans LBL, et al. Nat Commun. 2019 Mar 5;10(1):1060. doi: 10.1038/s41467-019-08936-1. Nat Commun. 2019. PMID: 30837465 Free PMC article.
Evidence for a genetic association of glycine with T2D is weaker, but we find a strong inverse genetic effect of hyperinsulinaemia on glycine. Our findings strengthen evidence for a protective effect of glycine on CHD and show that the glycine-T2D asso …
Evidence for a genetic association of glycine with T2D is weaker, but we find a strong inverse genetic effect of hyperinsulinaemia on …
Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.
Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T, Viikari J, Järvelin MR, Boehnke M, Laakso M, Mohlke KL, Fiehn O, Wang Z, Tang WHW, Hazen SL, Hartiala JA, Allayee H. Jia Q, et al. J Am Heart Assoc. 2019 May 21;8(10):e011922. doi: 10.1161/JAHA.119.011922. J Am Heart Assoc. 2019. PMID: 31070104 Free PMC article.
Mendelian randomization and other analytical approaches were used to determine whether glycine-associated variants were associated with CAD and traditional risk factors. Twelve loci were significantly associated with circulating glycine levels, 7 of which were not p …
Mendelian randomization and other analytical approaches were used to determine whether glycine-associated variants were associated wi …
SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study.
Xu M, Zheng J, Hou T, Lin H, Wang T, Wang S, Lu J, Zhao Z, Li M, Xu Y, Ning G, Bi Y, Wang W. Xu M, et al. Diabetes Care. 2022 Nov 1;45(11):2718-2728. doi: 10.2337/dc22-0323. Diabetes Care. 2022. PMID: 36161993 Free PMC article.
RESULTS: SGLT2 inhibition (per 1 SD, 6.75 mmol/mol [1.09%] lowering of HbA1c) was associated with lower risk of T2D and CAD (odds ratio [OR] 0.25 [95% CI 0.12, 0.54], and 0.51 [0.28, 0.94], respectively) and positively with total choline (beta 0.39 [95% CI 0.06, 0.72]), phosphati …
RESULTS: SGLT2 inhibition (per 1 SD, 6.75 mmol/mol [1.09%] lowering of HbA1c) was associated with lower risk of T2D and CAD (odds ratio [OR] …
Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.
Eckardt KU, Agarwal R, Aswad A, Awad A, Block GA, Bacci MR, Farag YMK, Fishbane S, Hubert H, Jardine A, Khawaja Z, Koury MJ, Maroni BJ, Matsushita K, McCullough PA, Lewis EF, Luo W, Parfrey PS, Pergola P, Sarnak MJ, Spinowitz B, Tumlin J, Vargo DL, Walters KA, Winkelmayer WC, Wittes J, Zwiech R, Chertow GM. Eckardt KU, et al. N Engl J Med. 2021 Apr 29;384(17):1601-1612. doi: 10.1056/NEJMoa2025956. N Engl J Med. 2021. PMID: 33913638 Clinical Trial.
Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis.
Chen N, Hao C, Peng X, Lin H, Yin A, Hao L, Tao Y, Liang X, Liu Z, Xing C, Chen J, Luo L, Zuo L, Liao Y, Liu BC, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Chen N, et al. N Engl J Med. 2019 Sep 12;381(11):1001-1010. doi: 10.1056/NEJMoa1813599. Epub 2019 Jul 24. N Engl J Med. 2019. PMID: 31340089 Clinical Trial.
Long-term results from the AGILE study of azacitidine plus ivosidenib vs placebo in newly diagnosed IDH1-mutated AML.
Montesinos P, Marchione DM, Recher C, Heuser M, Vives S, Zarzycka E, Wang J, Riva M, Calado RT, Schuh AC, Yeh SP, Tron AE, Hui J, Gianolio DA, Choe S, Patel P, De Botton S, DiNardo CD, Döhner H. Montesinos P, et al. Blood Adv. 2025 Oct 28;9(20):5177-5189. doi: 10.1182/bloodadvances.2025016399. Blood Adv. 2025. PMID: 40706052 Free PMC article. Clinical Trial.
Glycine increases fat-free mass in malnourished haemodialysis patients: a randomized double-blind crossover trial.
Genton L, Teta D, Pruijm M, Stoermann C, Marangon N, Mareschal J, Bassi I, Wurzner-Ghajarzadeh A, Lazarevic V, Cynober L, Cani PD, Herrmann FR, Schrenzel J. Genton L, et al. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1540-1552. doi: 10.1002/jcsm.12780. Epub 2021 Sep 14. J Cachexia Sarcopenia Muscle. 2021. PMID: 34519439 Free PMC article. Clinical Trial.
CONCLUSIONS: Branched-chain amino acid did not improve lean body mass as compared with glycine. Unexpectedly, glycine improved fat-free mass index in HD patients, as compared with BCAA. Whether long-term supplementation with glycine improves the clinical outc …
CONCLUSIONS: Branched-chain amino acid did not improve lean body mass as compared with glycine. Unexpectedly, glycine improved …
1,981 results