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Page 1
The glymphatic pathway in neurological disorders.
Rasmussen MK, Mestre H, Nedergaard M. Rasmussen MK, et al. Lancet Neurol. 2018 Nov;17(11):1016-1024. doi: 10.1016/S1474-4422(18)30318-1. Lancet Neurol. 2018. PMID: 30353860 Free PMC article. Review.
BACKGROUND: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. ...RECENT DEVELOPMENTS: Several features of the glymphatic and meningeal lymphatic systems have been shown to be present in humans. MRI scans wi …
BACKGROUND: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. ...RECENT D …
The Glymphatic System: A Beginner's Guide.
Jessen NA, Munk AS, Lundgaard I, Nedergaard M. Jessen NA, et al. Neurochem Res. 2015 Dec;40(12):2583-99. doi: 10.1007/s11064-015-1581-6. Epub 2015 May 7. Neurochem Res. 2015. PMID: 25947369 Free PMC article. Review.
Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. ...We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function …
Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. ...We will also discus …
Glymphatic dysfunction in Alzheimer's disease: A critical appraisal.
Keil SA, Jansson D, Braun M, Iliff JJ. Keil SA, et al. Science. 2025 Jul 10;389(6756):eadv8269. doi: 10.1126/science.adv8269. Epub 2025 Jul 10. Science. 2025. PMID: 40638744 Review.
A causal role for glymphatic dysfunction in AD has not yet been established in humans. We review current approaches to assess glymphatic function clinically, which capture different features of perivascular fluid dynamics or their results. The absence of clinically …
A causal role for glymphatic dysfunction in AD has not yet been established in humans. We review current approaches to assess glym …
The Glymphatic System: A Novel Component of Fundamental Neurobiology.
Hablitz LM, Nedergaard M. Hablitz LM, et al. J Neurosci. 2021 Sep 15;41(37):7698-7711. doi: 10.1523/JNEUROSCI.0619-21.2021. J Neurosci. 2021. PMID: 34526407 Free PMC article. Review.
Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the lymphatic system in the CNS. As such, the glymphatic system plays a key role in regulating d …
Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess fluid and metabolic waste. The gl …
The Brain's Glymphatic System: Current Controversies.
Mestre H, Mori Y, Nedergaard M. Mestre H, et al. Trends Neurosci. 2020 Jul;43(7):458-466. doi: 10.1016/j.tins.2020.04.003. Epub 2020 May 15. Trends Neurosci. 2020. PMID: 32423764 Free PMC article. Review.
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key r …
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is direc …
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep.
Hauglund NL, Andersen M, Tokarska K, Radovanovic T, Kjaerby C, Sørensen FL, Bojarowska Z, Untiet V, Ballestero SB, Kolmos MG, Weikop P, Hirase H, Nedergaard M. Hauglund NL, et al. Cell. 2025 Feb 6;188(3):606-622.e17. doi: 10.1016/j.cell.2024.11.027. Epub 2025 Jan 8. Cell. 2025. PMID: 39788123 Free PMC article.
On the contrary, the sleep aid zolpidem suppressed norepinephrine oscillations and glymphatic flow, highlighting the critical role of norepinephrine-driven vascular dynamics in brain clearance. Thus, the micro-architectural organization of NREM sleep, driven by norepinephr …
On the contrary, the sleep aid zolpidem suppressed norepinephrine oscillations and glymphatic flow, highlighting the critical role of …
The glymphatic system in migraine and other headaches.
Vittorini MG, Sahin A, Trojan A, Yusifli S, Alashvili T, Bonifácio GV, Paposhvili K, Tischler V, Lampl C, Sacco S; School of Advanced Studies of the European Headache Federation (EHF-SAS). Vittorini MG, et al. J Headache Pain. 2024 Mar 11;25(1):34. doi: 10.1186/s10194-024-01741-2. J Headache Pain. 2024. PMID: 38462633 Free PMC article. Review.
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. ...This review aims to summarize the role of the glymphatic system in the pathophysiology of migraine in order to provide new ways of approaching t …
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. ...This review …
The glymphatic system: implications for drugs for central nervous system diseases.
Lohela TJ, Lilius TO, Nedergaard M. Lohela TJ, et al. Nat Rev Drug Discov. 2022 Oct;21(10):763-779. doi: 10.1038/s41573-022-00500-9. Epub 2022 Aug 10. Nat Rev Drug Discov. 2022. PMID: 35948785 Review.
In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. According to the glymphatic system concept, cerebrospinal fluid flows directionally through the brain and non-selectively clears the in …
In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. Ac …
The Glymphatic System and its Relationship to Migraine.
Burgos AF, Olson PA, Vgontzas A. Burgos AF, et al. Curr Neurol Neurosci Rep. 2024 Oct;24(10):517-525. doi: 10.1007/s11910-024-01368-5. Epub 2024 Aug 16. Curr Neurol Neurosci Rep. 2024. PMID: 39150650 Review.
PURPOSE OF REVIEW: We aim to critically review animal and human studies of the glymphatic system in migraine and propose a model for how the glymphatic system may function in migraine, based on the available evidence. RECENT FINDINGS: Early studies in animal models …
PURPOSE OF REVIEW: We aim to critically review animal and human studies of the glymphatic system in migraine and propose a model for …
Glymphatic system dysfunction in neurodegenerative diseases.
Beschorner N, Nedergaard M. Beschorner N, et al. Curr Opin Neurol. 2024 Apr 1;37(2):182-188. doi: 10.1097/WCO.0000000000001252. Epub 2024 Feb 12. Curr Opin Neurol. 2024. PMID: 38345416 Review.
PURPOSE OF REVIEW: Purpose of this review is to update the ongoing work in the field of glymphatic and neurodegenerative research and to highlight focus areas that are particularly promising. ...SUMMARY: An open question in the field is to define the mechanistic underpinni …
PURPOSE OF REVIEW: Purpose of this review is to update the ongoing work in the field of glymphatic and neurodegenerative research and …
3,047 results